<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02661
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MAESNTISLVIPPEPSSKSQALESQIQQIIAQKGHFRHVTERSLLAEIHGKDVAADATQDGPEEEIPADDDETPQKRTERLWERRNQMLERLGAAQNDILCALDFVSWLISQQSVPARHSMSPPLKEAAPVGSLVARVLEEKPVPPPVRRQLVSVSQGWRSEGFHSASDKLSAASSRLKAEAEHESQFWRQVADLRAKGWPVSRLPRDRKAIGVHFGFAEAAPQFRDRGFALLLQAADGSVGLDARTLPKKSNCLAVYVVRNAVKTGAFHFESPRMSETADISQQLRDHRDALFEEELFFEISREARLVGNQGITARAQSVGIDMGDYQLSLISSDEQEIVLHTHDEDDLVAGFVGISLRLLLNAAHEQNLNRRTQKAPPMTTKTRTTPEYALIRPILTYLRHRSEARAFWNNCQNLLRAFEKANLPTAMSIENSNNAMFGSLKIEVPNTILSELMVPAKTSFKLKLTAGRDLQVGLATFLGPPLLGSRYETSPIDFGFSKTPMSRHETRDAALASVRQMLLLDLVAHTETLTRAAATNTGANNSTHGEWILSQPHSGEFTMYDGQEAVRKMQLSVHTESISLKLGPMKKRPSSSIVVWTWTGAGCSKAEGNVTTKEQDTTFDAAMKQLLAIGC |
Length | 634 |
Position | Head |
Organism | Phialophora americana |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Phialophora.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.376 |
Instability index | 48.13 |
Isoelectric point | 6.68 |
Molecular weight | 70148.69 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP02661
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.37| 23| 40| 295| 317| 1
---------------------------------------------------------------------------
295- 317 (38.83/28.79) EEELFFEISREARLV.GNQGITAR
337- 360 (35.54/25.72) EQEIVLHTHDEDDLVaGFVGISLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 90.35| 27| 51| 503| 532| 2
---------------------------------------------------------------------------
503- 532 (41.41/30.52) PMSRHETRDAALASVRQMlllDLVAHTETL
555- 581 (48.94/28.92) PHSGEFTMYDGQEAVRKM...QLSVHTESI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 90.94| 33| 43| 119| 159| 3
---------------------------------------------------------------------------
107- 155 (44.90/32.50) S..WlisqqsvparHSMSPPLKEAApvgslvARVLEEKPVPPPVRRQLVSV
156- 195 (46.04/27.91) SqgW.....rsegfHSASDKLSAAS......SRLKAEAEHESQFWRQVADL
---------------------------------------------------------------------------
|