<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02652

Description Uncharacterized protein
SequenceMTSNPLAEPRPPSSRHPPDVPRPSLDRAASDIPSSLGRRPTGPQRQYTEPTQDRPTKRRKVEGDGISTQASNAGNASTVTITANAPTATQHGTSQLRLVAPTASALLFDPRYSQDGEKVEATEDNGLPDLPPRPWDLGRKSKTTEDPLPTHRSRIYVPVPTTPDSLVSPERAPHFVPQKAAGYFPWNGKHPEDVLSDVNVKQGYFDKPPNPTEKELNTARVPLYNAFKHKSGVDSLSVLFSLILDKKSQQSLINVPTTFKPPPRVTLTEAKRKSWIADLANADVPLRRLSRTIPQGIRGQLLLDQCLQNRVPLSRAIWFAKCVCANEIRTLKRKGTTPAIAMGTEGKWLREWTVSVEQFLESHLGQAGSPDWRTDIQYAIRISTRLYMESLLDRDHYLDWILRSLAAASLEQLPFWLMISHIYRQDISYYRRRGRKLAETLIEKYELVQKTAGQGAAPLLQRLHHAIRGLLLSRPRNFLMPDKWPEIHSIVQKCLDGKIQQETQILEELNRINERTMGFNRGDFSTKRSPIQEIVELLDTLKPPFDVAKLAVDLTTICSDTDVVISTCIEWACTQFRSSNARIYLFARLLRRWQRAGHEVDNVILNFLSSCREGKTTADPQCLRHLIAQLSRSNSFPTAKYLQWLMVRGLPKAGTVTLDQDTGVGTNSICDFSEFNYFLLDLSLQNTGTHVVHLRNSILARCGFDLSSEEELYQHHIRYMEQQLSQLFIGASSSTPTISEPSFASLPWCVKSRISMWLRAKAVQMAMRDMPGLSTSSGLLSSTRTDCAQFSFIRYILECMDDEPVLADVVGIFCNSQDDAMVASLAATIQAHSEAFQAIGAFEVLQRRLCQIYMAWRSTKPAMPLFTNLLLDLCSAFPVATPTVKSLQQDFVRGDRGRAVAACSPYSDGIAESLQQAGATFVEDFEAILQSEPNMSEQTMNGLFSVLVDRIEKQQKFGDDSLTLFSFCQLLSRLRLCRKGQADQLIQKWLMRLAPFLDDTFGPSLFQNLIGAGCVTFAGFLEALDMTKLQLRKLPSAATLLRRVNIPDKESLSNLALYQTRTRWIEYCRREPQRALEVLIQLGKEDSKAASRIRLVHSLAINPPLTSAHLSDSVITLLIQTVDGLLHPGNTVTDTVDLRALLSGINIFSQRHIQLRLWLMSHARAEEPSDGQSQLVNILSETLERTLRDQDAQQGNVAQWLHTAGPEVANRLRHKVESEFLEALPKFPTGKTSSPLSAVFPSDVQHLSAIVDRAFRVCVKNTSPMPGFMTQLIEKLTQIFKSQNSHAAALSGLPGNSVNVSPAQMVTSSPNASSFEATGGSSAWATLNCLNSILHMVCLQRSAVISAARIGPNTKQGQSEQVQLLVRLALIFTHPTLAAGTAHVNNKQEEERVKNVHDFILDVIATIVDHVGDEVKMMCAKLLKDKVHDVRLQYLFGSVNITGSIQSRDLGQGLQMVKEGRGIIGEWRPRVWEILDNGSGKENETSLGLGLFGARRERLSED
Length1502
PositionKinase
OrganismExophiala oligosperma
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.269
Instability index50.37
Isoelectric point8.67
Molecular weight167581.65
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02652
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.02|      25|     169|      11|      43|       1
---------------------------------------------------------------------------
   11-   43 (42.06/34.51)	PPSSRHPPDVprpsldraASDIPSSLGR..RPTGP
  185-  211 (45.96/22.33)	PWNGKHPEDV........LSDVNVKQGYfdKPPNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     727.77|     132|     169|     879|    1010|       2
---------------------------------------------------------------------------
  456-  627 (122.86/63.67)	.AAPLLQRLHHA.IR..............GlllSRPRNFLM.PDKWPE.IHS.IVQKCL......DGKIQQETQILEELNRINERTMgfnRGDFSTKRSPIQEivelldtlkppfdV..AKL.AVDLTTICSdtdvvistciewactqfrssnariylFARLLRRWQ..RAGhEVDNVILNFL..ssCREG...KTTADPQCLRHLI
  634-  780 (151.40/80.16)	NSFPTAKYLQWLMVRglpkagtvtldqdtG...VGTNSICD.FSEFNYFLLDlSLQNTG......THVVHLRNSIL.ARCGFDLSSE...EELYQHHIRYMEQ.............QlsQLFiGASSSTPTI..........................SEPSFASLPWCVKS.R....ISMWLrakaVQMA..MRDMPGLSTSSGLL
  792-  877 (84.37/41.42)	FIRYILECMDDEPVL..............A...D...VVGIfCNSQDDAMVA.SLAATI......QAHSEAFQAIGAFE..VLQRRL...CQIYMAWRSTKPA.............M..PLF.TN...LLLD..........................LCSAF............................................
  879- 1010 (205.29/111.32)	VATPTVKSLQQDFVR..............G...DRGRAVAA.CSPYSDGIAE.SLQQAG......ATFVEDFEAILQSEPNMSEQTM...NGLFSVLVDRIEK.............Q..QKF.GDDSLTLFS..........................FCQLLSRLRLCRKG.QADQLIQKWL....MRLAPFLDDTFGPSLFQNLI
 1044- 1179 (163.86/87.37)	VNIPDKESLSNLALY..............Q...TRTRWIEY.CRREPQRALE.VLIQLGkedskaASRIRLVHSLAINPPLTSAHLS...DSVITLLIQTVDG.............L..LHP.GNTVTDTVD..........................LRALLSGINIFSQR.HI.QL.RLWL....MSHARAEEPSDGQSQLVNIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.25|      16|      17|     143|     158|       3
---------------------------------------------------------------------------
  143-  158 (30.69/16.48)	TTEDPLPT.HRSRIYVP
  161-  177 (23.55/10.79)	TTPDSLVSpERAPHFVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.46|      39|      91|    1248|    1292|       6
---------------------------------------------------------------------------
 1248- 1292 (53.61/54.31)	SAIVDRAfRVCvKNTSPMPGFMTQLIEKLTQIFksqnSHAAALSG
 1342- 1380 (64.84/43.29)	SAVISAA.RIG.PNTKQGQSEQVQLLVRLALIF....THPTLAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.85|      17|      19|     102|     118|       7
---------------------------------------------------------------------------
   82-   94 (22.36/10.27)	TANA......PTATQHGTS
  102-  118 (30.62/16.95)	TASALLFD..PRYSQDGEK
  122-  140 (27.87/14.72)	TEDNGLPDlpPRPWDLGRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02652 with Med12 domain of Kingdom Fungi
Unable to open file!