<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02651

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMAEQETQLPEAPFPAPPPFWRHFTTANEEKLKELESSAGGPPEKLPIPLAYLRPPPPPPDTAEVYTTFGQNQVIDPTKPSSLPRDQLLFNPDDPNLNHAVLLSRLTKSLMLNFLELTGVLSLDPTQYEEKMGDIRQLVLNIHVVINMYRPHQARESVKEMLEGILEDGQREIEESDRLKQRVEDFLGDLGKMESHAGSEGLAQRNTTPANGAKSDAKMDEQRRMWQMIHDMVD
Length233
PositionMiddle
OrganismExophiala xenobiotica
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.06
Grand average of hydropathy-0.678
Instability index51.55
Isoelectric point4.88
Molecular weight26371.56
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02651
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.44|      18|      41|       8|      25|       1
---------------------------------------------------------------------------
    8-   25 (39.74/15.88)	LPEA...PFPAPPPFWRHFTT
   47-   67 (31.70/11.55)	IPLAylrPPPPPPDTAEVYTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.95|      19|      43|     167|     185|       3
---------------------------------------------------------------------------
  149-  164 (18.39/ 7.50)	...R...PHQARESVKEMLEGI
  167-  185 (29.98/15.58)	DGQR...EIEESDRLKQRVEDF
  210-  231 (28.58/14.61)	NGAKsdaKMDEQRRMWQMIHDM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02651 with Med7 domain of Kingdom Fungi
Unable to open file!