<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02647

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDSVALDPLSSLENHLNALVANITQTNTFANAPQLAKDLVTDDDNLSSALTLLRKHQQNYARLLNLRVEVEDLQTQLQDTIRRSVAFRDEILQIHPTILDDSDEEEEDDDDDAQNNITEIDYHTLLAFAARIGKHNAAAAREAEAEAVRRKVAAKREAVNGAADGEENATAETEAEVERINNTVAQTRAQMGMAFPDANLLRVGALGQLQLYQEKQATAGANVEDALDREVERLVRESEDIAEAVVEPVENTAAEEGMGWSSPELAKRTLPGPSGQTEQAHGSGQASMPQQVKRQGGDLPPAPPKRKVALDFPGSDDEEDDD
Length322
PositionMiddle
OrganismExophiala oligosperma
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.03
Grand average of hydropathy-0.661
Instability index57.49
Isoelectric point4.39
Molecular weight35103.98
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364141

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02647
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.26|      11|     210|      99|     109|       1
---------------------------------------------------------------------------
   99-  109 (21.23/13.12)	LD..DSDEEEEDD
  310-  322 (17.03/ 8.98)	LDfpGSDDEEDDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.64|      22|      22|     238|     259|       2
---------------------------------------------------------------------------
  238-  259 (35.58/24.77)	SEDIAEAVVE.PVENTAAEEGMG
  262-  284 (34.06/23.39)	SPELAKRTLPgPSGQTEQAHGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.96|      30|      31|     133|     163|       3
---------------------------------------------------------------------------
  133-  163 (45.07/36.43)	GKHNAAAAREAEAEAVRRKVAAKReAVNGAA
  165-  194 (51.89/37.12)	GEENATAETEAEVERINNTVAQTR.AQMGMA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02647 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKREAVNGAADGEENATAETEAEVERINNTVAQTRAQMGM
2) QEKQATAGANVEDALDREVERLVRESEDIAEAVVEPVENTAAEEGMGWSSPELAKRTLPGPSGQTEQAHGSGQASMPQQVKRQGGDLPPAPPKRKVALDFPGSDDEEDDD
154
213
193
322










Molecular Recognition Features






MoRF SequenceStartStop




1) ELAKRTLP
2) MPQQVKRQGGDLPPAPPKRKVALDFPGSDDEEDDD
264
288
271
322