<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02645

Description "Unplaced genomic scaffold supercont1.3, whole genome shotgun sequence"
SequenceMTSISPAEPRPPLLRRSTDSNRPPHGRASSHIFSPLDRKPPTLRRETVETEEDRPIKRRKIEADSNSNQVANHHNTSLPDKVSDPHVDNKTVYWRWVRPSAIRAAVANSRSKEEEDTSSEDGLPELPPRPWRTARVAKVADKAAPTHRSRVDIPVPNTPDSIQVPSSAPQFVLKRPVGFFPWTGKHPEDILSDSNVKNGYFDKPPNPTEKELNTARVPLYNAFKHKSGVDSLSTLFSLVLNQKSQHGIISSVSTFKPPPRVTLTEAKRKSWIADLANADVPLRRLSRTIPQGIKGQTLLDLCLQSSVPLSRAIWFAKCVCANEVRTLKRKGTTPAVALGAENKWLREWTLNVEQFLETYLGQANASDWRSNIQYALRLNTRLYLENLLDRGHYLDWILHSFTTAAISHTPFWLMVIHIYKQDLSQYRRRGAKLAQALIDKYRSIDNLSDQSISPLRQKLRAAVRELLFSRPAIFLMPDRWPESVPIVQTCLDTTIGPEGLILEELNRINERAMGFNKTDFLSVRSPSEIIVETLDKARVPYNVALLAKELDETSTDFDLLLRSCLEWSCTRFRQSRTRLYLVTRLVKRWQRGGRDIDTPILNFLSAFREGKTTADTLCLRHLVAQFSRSDCFPLSKYLQWLMVRGLPEKGSVCIDTESIFGRTAKVESYRDFASVQFLLDLSLHRAEDHVINLRNSVLERAGFDPSAEEDIFERCVEYLEQKLADASFVTKSEPPTLHEPSFAALPWTLRTRISMWLRARALEAAKSAQSTPMLPGSKVLNEEQFFVIRHILECMEDEAVLADVVGILSVSQRDDLVASLVATVHFHAGSFSAIGALEVLQKRMCQIYMTWRSTKPTMPLLTSTLLDLCTAFPVKAPAIRLLQQDLVRGDRGRAVAACSPYSDGIAESLQQAGATFVEDFEAILQSETNMNEQTMNGLFSVLVDRIEKQQKFEDDPRTLQSFCQLLSRLRLCRKAQGDLLTQKWMSRLMSCLDSKSGPSFLRILVATGCITFATIFEATPGYKSGVRKNLAVASFLYQILAPPSSTSLDWAAYQTRTRWHEYSLKEPLTALEIVCEAGLQGVSPTFDSLLLVVLVNSWSPDSSSLAEPAKKWFVKSLSYALNCSDGDLNATDLQALLESINVFSHRFVQLRFRLASPASVDKASGLDQPDLIEVLSQSLKQTLRNPPSPYAGHRQRFSQLFQIVGPDVANQVRHNVENEFLYALPKLLVGRVTSPLSAVFPDDTQQLSSIVEQAFQVCRKETSPSPGFLSHLIDRLSQHLKYLGNTHNTPATPAAPATTAPTAPTGFSGPSGSSTTMTHSQMVSMSSSPVANTSDIGGGSCPPVGLSYLRCILQMVCLQRPTLISPGSNGANVKQTQNEQLQLLVRLASIATHPAMTLVTGHQGTREEQIKAKEVIEFALDVIATIIDGVSDEVHLMCAKVLKDKLQDTRLCYLFGSINLMGSAQVQDMGRGLQMVKEGKGIIGEWKPRMWEVLDSGSGKESETSLGLGLFRARYG
Length1516
PositionKinase
OrganismFonsecaea pedrosoi CBS 271.37
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.07
Grand average of hydropathy-0.254
Instability index52.75
Isoelectric point8.77
Molecular weight169251.64
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02645
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.24|      21|     101|    1171|    1191|       1
---------------------------------------------------------------------------
 1171- 1191 (38.44/26.47)	LIEVLSQSLK...QTLRNPPSPYA
 1272- 1295 (33.81/22.23)	LIDRLSQHLKylgNTHNTPATPAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.57|      29|     101|      23|      69|       2
---------------------------------------------------------------------------
   40-   69 (46.58/51.16)	PPTLRRE.......TVETEEDRPIKRRKIEAdSNSNQ
  734-  769 (43.99/14.68)	PPTLHEPsfaalpwTLRTRISMWLRARALEA.AKSAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.79|      36|     256|     589|     635|       6
---------------------------------------------------------------------------
  589-  635 (48.55/54.93)	WqRGGRdidtPILNFLSAfregkTTADtLC.........LRHLVAQFSRSD.......CFPLS
  851-  902 (54.24/30.38)	W.RSTK....PTMPLLTS.....TLLD.LCtafpvkapaIRLLQQDLVRGDrgravaaCSPYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.63|      11|      27|     350|     360|       9
---------------------------------------------------------------------------
  350-  360 (19.07/12.50)	LNVEQFLETYL
  378-  388 (18.57/11.97)	LNTRLYLENLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.82|      26|      27|     105|     130|      18
---------------------------------------------------------------------------
   70-  101 (29.63/14.33)	..VANHHNTSLPDKVSDPHVDNktvywrwVRPSA
  105-  130 (42.38/23.86)	A.VANSRSKEEEDTSSEDGLPE.......LPPRP
  134-  159 (35.82/18.96)	ArVAKVADKAAPTHRSRVDIP........VPNTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.59|      18|     295|     711|     728|      24
---------------------------------------------------------------------------
  711-  728 (33.18/22.32)	IFERCVEY...LEQKLADASF
 1015- 1035 (27.42/17.16)	IFEATPGYksgVRKNLAVASF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02645 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAVANSRSKEEEDTSSEDGLPELPPRPWRTARVAKVADKAAPTHRSRVDIPVPNTPDSIQVPSS
2) MTSISPAEPRPPLLRRSTDSNRPPHGRASSHIFSPLDRKPPTLRRETVETEEDRPIKRRKIEADSNSNQVANHHNTSLPDKVSDP
3) YLGNTHNTPATPAAPATTAPTAPTGFSGPSGSSTTMTHSQMVSMSSSP
104
1
1282
167
85
1329










Molecular Recognition Features






MoRF SequenceStartStop




1) HIFSPLD
2) VDNKTVYWRWVRPSAI
31
87
37
102