<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02642

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGDRPMVNGERIPNGVQHSLASSTSDIGLLKEAQNLKSISASTNEDSKLPVNGQHVAGPISGADPLRDVANGLEQASQEILQLVPKDSYLPMAALISRTSQMCWNGLSNLVGQLAEIQVPQLPPEQTKTFANNLPNNQTKANLDKKDRLLKFANEQKADFIKLLVLLDWSKHVDQVSKTISINFWLMRRRQAYWNAISSLALLKQDSAGFQVPNPDLKVAAEVLSKGKVAQFPTLGYISQKDLSTKQIVRFLRNLDHALSVKLSLATNLPSQLRRFRVHDGRATFTVSNEFELDVSILSEAEDAQFRMVDFRFAFSPAPAVNDALHSEIERLANSNIDRDGLNGCYLFLHELTLSYKLAEYHRQALELSRGQWAGNLRVEMIRRNLVIQYWTERQSTKSWIEFGISSGTDVGHTPGKDPVPSLEVKWMRNGKKVDSLQLWLDDSRLSFEDILRQVIAQHSTQLLDSIYDKLILAPLFGDGELALQQDASEDDPDECSLTMQLSQKSQLSIKVDAVSGNLVVSPVSERSERLQYEINRVYNVADEVVSKLLNFRCSVMEAAILAAIAGTSWESLPAFRLTQAEIKTLFGPSIIRINLVRQVQWGLGFFLVVTHGQNGDKWWLLQRTSTTNTISQAQFQILSSQKIEVEERLCPAYFERLAEYATGVICLQRNVDFLRDAKTKFDLPPFPIFEQNFALPELTFELDMSKPTFADQLHALQDSIPPAAVAVASPTSPKRIRLRFGGVDRATDRVLTIARIRDGASKRILHRLDKSMLGDNVDLDSKSGTLTIRVQNSTSEAAVPAIVDKAMNLEKSLAIMEQVYRLPALKLKAISNSSFTISYHHDGPTELGVTITVGPASPIPQLEFYPPDTNPHVHLAPYYPKLFQSSRVPFSTKVGNFMTSLILTYPMVEYLQGLQKRHGLDAQNPQPRSGNPESDIRVHVLVRGVAAWAVQYFTTRARAPADVGTQSQPHLLARLEIVQHISTSDKPMWLVRAALEDFQSYSRPSYVTPALRIKLRQEIFARSDNKSSWLALDNAAACVADKPEPLLSSIHDVMCAWVKQPPEPIATPGQSTQARKQSAAGQDNVPNGTSRPKAAGKQQTGGNGIPNGPMKQRPSISNSIRGGKGSSGISKNSEVITLD
Length1141
PositionTail
OrganismExophiala oligosperma
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.290
Instability index42.22
Isoelectric point8.57
Molecular weight126675.77
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02642
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.41|      17|      17|     965|     981|       1
---------------------------------------------------------------------------
  965-  981 (29.47/20.41)	VGTQSQPHLLAR..LEIVQ
  983- 1001 (26.94/17.95)	ISTSDKPMWLVRaaLEDFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.83|      13|      15|     739|     751|       2
---------------------------------------------------------------------------
  739-  751 (23.12/12.94)	RLRFGGVDRATDR
  757-  769 (22.70/12.58)	RIRDGASKRILHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     692.10|     188|     205|     324|     528|       3
---------------------------------------------------------------------------
  170-  322 (163.67/89.61)	..........................................................WSK..H..V...........DQVSKTISINFWLMRRRQAYWN..AISSLALLKQdSAGfQVPNPDLKVaaEVLSKGKVAQFPTLgYISQKDLSTKQIvrfL............R.........NLDHALSVKLSLA..TNLPSQLRRFRvHDgrATFTVSNEFELDVSILSEAE.DAQFRMVDFRFAFSPAPAV
  324-  528 (299.25/205.53)	DALHSEIERLAN..SNIdrdglngcylflheltlSYKLAEYHRQALE......LSRGQWAG..NLRV...........EMIRRNLVIQYWTERQSTKSWIEFGISSGTDVGH.TPG.KDPVPSLEV..KWMRNGKKVDSLQL.WLDDSRLSFEDI...L............RQVIA.QHSTQLLDSIYDKLILA..PLFGDGELALQ.QD..ASEDDPDECSLTMQLSQKSQLSIKVDAVSGNLVVSPVSER
  530-  736 (229.17/134.43)	ERLQYEINRVYNvaDEV.................VSKLLNFRCSVMEaailaaIAGTSWESlpAFRLtqaeiktlfgpSIIRINLVRQ...........VQWGLGFFLVVTH.GQN.GDKWWLLQR..TSTTNTISQAQFQI..LSSQKIEVEER...LcpayferlaeyaTGVIClQRNVDFLRDAKTKFDLPpfPIF.EQNFALP.EL..TFELDMSKPTFADQL.HALQDSIPPAAVA...VASPTSPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.12|      16|      17|    1075|    1090|       4
---------------------------------------------------------------------------
 1075- 1090 (28.17/15.09)	QARKQSAAGQDNVPNG
 1095- 1110 (28.95/15.70)	KAAGKQQTGGNGIPNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.92|      28|     889|      29|      58|       6
---------------------------------------------------------------------------
   29-   58 (42.14/27.64)	GLlkEAQNLKSISASTNEDSKLPVNGQHVA
  921-  948 (49.78/27.45)	GL..DAQNPQPRSGNPESDIRVHVLVRGVA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02642 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SISASTNEDSKLPVNGQHVAGPISGADPLRDV
2) VKQPPEPIATPGQSTQARKQSAAGQDNVPNGTSRPKAAGKQQTGGNGIPNGPMKQRPSISNSIRGGKGSSGISKNSEVITLD
39
1060
70
1141










Molecular Recognition Features






MoRF SequenceStartStop




1) GPMKQRPSISNSIR
1110
1123