<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02641

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNTTLEFPSNCSTNVYTLNDFGEIAYIVCTVATPPTQDPSQIVSSVENTLARLRRTERQFREASILAALDVEARQLFTFYKKVDITAPKDQKTLLLKFGYVLRSNTCTIAYKTAARLPDLLKPEHSRLYRLFLTAIVSSIKFVPNGETDIQPLGANLYLVEQSPSVADVRQLDRVKKWLLYRIDLQVVSSGHIILTIAKDGAFSFLRVPDCAPTLNWNDHTQSEATAIYLAPIARIARSTRSKILAHKRFAGTPGNAANDETPLSDARREIWREVLPTWLKEQMNTSIDAMEADWIEIEVPVEEVDHVYNENQQDNPSPESIKCDSVTWKTIFWPVDLCFVFAVEESVTPKEPQGNHDPMQFVWDWILGTGGNASKLEADPQKVVDEDDEPLFADEGAFDDPVHFHPFGPPAFGAGQTIYPTPPDVGMTHPTPGFSSFDGMSMTPANLPRSTAERPLPQDQDMPDFEDEPTTGGLQTYYDEDLFEEHPDDNLGAEANGDEPNWDFFDGPGIDPTSARSASHGRLEETAVSGETQPGTEAHGRIAGQNDASQGPSVVEGNSTGSDIAPKLPANTKLQQSQEQMEEPTSILQLQNKQTPQPSSKQGPPLWQPEAAREPRIGAERGRRSSLYDDPYSLLSVSTHDSRYGAGGDYWFDPTPILSNMEGYPKPSPVFRRPASSSSDSDSLMTSSSNSANPVSRQSTAHVPFRQWTEYQPPSPNAASRQPEVAKLTLYQDVQQILGSLRPGLIEPPAPSDFQLDTLEPRKIPPVSPQTLLQIAHVLVEQMSQTTLLPHGEYSRETHRPPRDHMDVSVDLSGINTSATPSNVFQLTSLKAEQNNGRVQGKVVRILPDQIRARRMERPLTATISILNFWDSLNLQPENGPKDVTVFCIHPNQSNVAEGCLNLLQRLAETYTSCSLGSHTIGRLSGLTDTGLVSWGSNDTGEHNLLQTCHFVGKALATTSDVKGTVLVCVIGRNQSVNSYLEACIAFFSLFESFREARTDNHGVSDIALQVIPKEFVASAESLVIPPQTAYIRLAIEIYNRIPPSEPPVSPAACSSAVVLSKTETSVHLQLTPTYCSPLEKHGPCLHLAYSVSQDNRWLTAAWTDETGHVALSMSYCLRIRHSGKNRSRHGIFREMWDISQDLMSKMRGPWRLVVVRHGYYEQTELLDWHQLFENSPSSQKRCLLVLLSVQLDPDLEIFPPSTQGKGTQMGTQNLYGTPASTPQGSMTSPEQTVPATPTPGGSSFMNAPTPSDPGFDPNNESDLVLVDPSEESWGVILPYGINQTRSLIELRPSQLTGYLMKRKGTKGEDGYNMLEFSLVTSSTRISDASSEAPPDELLEDLIKQYRGLVTLGATRGCVDPNSECLPWHIATAIRGAQLLGQVM
Length1385
PositionKinase
OrganismFonsecaea pedrosoi CBS 271.37
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.07
Grand average of hydropathy-0.435
Instability index51.14
Isoelectric point5.01
Molecular weight152909.52
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02641
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.58|      67|      73|     325|     396|       1
---------------------------------------------------------------------------
  325-  396 (115.77/59.77)	DSVTwktiFWPVDLCfVFAVEESVTPKEPQ.G.NHDPMQF.VWDWILGTGGNASKLEAD.P....QKVVDEDDEPL......FADE
  401-  481 (103.81/43.78)	DPVH....FHPFGPP.AFGAGQTIYPTPPDvGmTHPTPGFsSFDGMSMTPANLPRSTAErPlpqdQDMPDFEDEPTtgglqtYYDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.85|      22|      40|     830|     851|       2
---------------------------------------------------------------------------
  830-  851 (37.42/20.30)	SLKAEQNNGRVQGKVVRILPDQ
  873-  894 (41.44/23.20)	SLNLQPENGPKDVTVFCIHPNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     608.54|     192|     484|     586|     793|       3
---------------------------------------------------------------------------
  496-  639 (203.39/106.55)	...........ANGD.....EPNWDFFDG.PGIDPTSARSASHGRLEE...TAVSGETQP.GTE..AHGRIAgQNDASQ.................................................GPSvVEGNSTGSDIApKLPAN.TKLQQSQEQM.E....EP......................................................TSI.LQLqnkqTP...QPSSKQGPPLWQPEAAREPrigaERGRRSSLYDDP.YSLLSVS
  640-  793 (216.20/117.38)	THD....SRYGAGGDYWFDPTPILSNMEGyPKPSPVFRRPASSSSDSDslmTSSSNSANPvSRQstAHVPFR.QWTEYQ.................................................PPS.PNAASRQPEVA.KLTLY.QDVQQILGSL.RPGLIEP..PAPSDFQ.LDT.....LEPRKiPPVSPQTLLQIAHVL..VEQMSQTTLLPHG...........................................................
 1024- 1116 (74.71/28.21)	....................................................................................................................................................................LVIP..PQTAYIR.LAIeiynrIPPSE.PPVSPAA.CSSAVVLskTE...........TSVhLQL....TPtycSPLEKHGPCLHLAYSVSQD....NRWLTAAWTDETgHVALSMS
 1122- 1282 (114.24/47.72)	RHSgknrSRHGIFREMWDISQDLMSKMRG.P................................................wrlvvvrhgyyeqtelldwhqlfenspssqkrcllvllsvqldpdleifPPS.TQGKGTQ..MG.TQNLYgTPASTPQGSMtSPEQTVPatPTPGGSSfMNA.....PTPSD.PGFDPNNESDLVLVD..PSEESWGVILPYG...........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.96|      56|    1217|      71|     147|       4
---------------------------------------------------------------------------
   75-  133 (86.83/71.60)	QLFTFYKKVDITAPKDQKTLLlKFGYVLRSNTCTIAYKTAArlPDLLKPEHSRLYRLFL
 1296- 1351 (94.13/58.73)	QLTGYLMKRKGTKGEDGYNML.EFSLVTSSTRISDASSEAP..PDELLEDLIKQYRGLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02641 with Med13 domain of Kingdom Fungi
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