<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02637

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVEVMATNLDYPSNCATNVYTLNDFGEIAYIVCTVATPPTQDPAAFTSTPEATLARLRRTERQFREASILAALDVDNRQLFTFYKKVDIANAKDQKTLLTKFGYVLRSNTCTIAYKTAARLPDLMKPDQARLYRLFTTAIISSIKLLPNGDSTLQPFGPKLYIVRRGESDTEVDHFEPRNIWTLYRIDVQVIPSGQIVLTILKERHHVFRRVLDLGKELELERSAIPCNYPVYLAPLGRVARLTSNANGATSTILNYDEGQDAVPSHEVAPEKELWKEVLPAWLSEHTNITLDHGNVTWVEVQVAVHDVEPSPADNTTASSPPSSKLGSISWKTLLWPSSLCFTLDKGRTGLAETFGGNQDPIRFVRDWLVGTFSDNSNVNAQSHVPNMTDSDDDEPLFAETGTFDDPDHFQPFGPPAFPASQAVYPTPPDAVMTHATPGFSSLDGLAMTPANLPGKVSDFMRRSDVEMQDFDGMNNDGAMSGYYDEDLFEEMTEDQFEQGNAADEPNWDFFDRPGVDLKPRSAEDAGVKDADTAMHDIGDNNDSKVPLHENVNDEKYTEQSGVLISPSERIDYHQSLGPTDQTEMVGSSETGNLERVKLQTTQAAALDGGQYKSRTTAARRRSSIYEEVRPPGRSSHHDDKYTANGGFWFDPNPVAVSTNSSLKLLSVIQRSASSSSEDDESSDGDSSSPNQISSGRKALVPSRAWTEYHPGSPMTVTHQNEYDKATAETDIRQLLEVLKPVAIQPTPIIDIRTTNHVFRPDETLDQNLLQIAQILVDQVSQTSLISHADQDNKHKVLTDDHIDIIADLGVLGSSSSPMTLSQLVLMKADTPNVRPQGKISKLQPNQVRMKRADQPLVASLPILSFWDTLNLQPAHGLKDAIAFCVHPEGEDVADGCSNLLQRMSDTYNTCALGLHTVGRLSGMAGDGRVSYYSTAEASSNVRQVCQKMGSTLAAASDLTGTVLIYMISQDDSPAAYLEMCKAFNCLFESFAANTDRKSITDMALQIIPRSFVASPASLVVPPQAAYLKLALEVYNRLPPIDNSRSPAACDAAITLAKVENPVHLQLASTFASPLSNNGDYLHLAYSMTPDGRWIAAAWTDEQGRISLSMSYCTRWKDSRQVRPRQEIFKEMWLVSHDLMGKNRGLWRLAIVKHGFYMPLELQEWRQVFESSTTTQKRCSPMLLSAHLESMVKVFPRTITGKLVQTGQNVFGTPVSTPQAGVTSPDQHIPATPTPGGTAVINAPTPPEPGLDPNVELDLTLLDPAEESWGIILPYGLNQSKNMIEIRPAVVSAVLLKRRGPKIEEGFNSLEISLVYLASQAAVGFGQTAPDDLLEDVIKQYRGLLTLGVSRGCVDPLKESLPWHVATVARGSRALGEVL
Length1380
PositionKinase
OrganismExophiala oligosperma
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.341
Instability index46.49
Isoelectric point5.06
Molecular weight151781.94
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02637
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.26|      41|     391|      10|      50|       1
---------------------------------------------------------------------------
   10-   50 (75.51/36.16)	DYPSNCATNVY....TLNDFGEIAYIVCTVATPPTQDPAAFTSTP
  395-  439 (71.74/34.03)	DEPLFAETGTFddpdHFQPFGPPAFPASQAVYPTPPDAVMTHATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.25|      19|     391|     683|     709|       2
---------------------------------------------------------------------------
  686-  708 (30.96/34.10)	GDSSSPNQISSgrkaLVPSRAWT
  814-  832 (34.30/12.47)	GSSSSPMTLSQ....LVLMKADT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.60|      70|      83|     496|     568|       5
---------------------------------------------------------------------------
  496-  568 (116.03/76.35)	DQFEQGNAADEPNwdfFDRPGVDLKPRSAEDAG.VKDADTAMHDIGD.NNDSKVPLHENVNDEKYTEQSGVLISP
  582-  653 (113.57/66.11)	DQTEMVGSSETGN...LERVKLQTTQAAALDGGqYKSRTTAARRRSSiYEEVRPPGRSSHHDDKYTANGGFWFDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.44|      16|      16|    1211|    1226|       6
---------------------------------------------------------------------------
 1211- 1226 (28.58/15.95)	VFGTPVSTPQAGVTSP
 1230- 1245 (28.86/16.19)	IPATPTPGGTAVINAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.83|      35|     448|     445|     485|       7
---------------------------------------------------------------------------
  445-  485 (51.85/44.46)	DGLamtpANLPGKVSDFMRRSDVEMQ...dFDGMNNDGAMSgYY
  896-  934 (60.98/32.99)	DGC....SNLLQRMSDTYNTCALGLHtvgrLSGMAGDGRVS.YY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.24|      45|      72|      55|     102|       8
---------------------------------------------------------------------------
   55-  102 (68.31/56.94)	ARLRRTerqFREA..SILAALDVDNRQLFTFYKKVDIANAKDQKTLLTKF
  130-  176 (72.94/52.07)	ARLYRL...FTTAiiSSIKLLPNGDSTLQPFGPKLYIVRRGESDTEVDHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.56|      15|      16|    1135|    1149|       9
---------------------------------------------------------------------------
 1135- 1149 (28.10/19.46)	LVSHDL.MGKNRGLWR
 1152- 1167 (24.46/15.90)	IVKHGFyMPLELQEWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.02|      34|     816|     271|     311|      10
---------------------------------------------------------------------------
  271-  311 (49.50/53.15)	PEKElWkeVLPAWLSEHTNITLDHGNVT.WVEVQvavhDVEP
 1091- 1125 (61.52/41.49)	PDGR.W..IAAAWTDEQGRISLSMSYCTrWKDSR....QVRP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02637 with Med13 domain of Kingdom Fungi
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