<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02636

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDQDQPDDFASESFFDQNSLQQQIQQIDATADLNAISNVVLPPNPAVIDKLSRRWYCGCLERIAWSRHGHLASISDDGSTVYLECIRYNYETKSWGLHERHSLTTLFEDATSLAWSPNGGELAVVDVKGRIWIYHNSLLAVNRLILARQGALDEGNEYSQPVGMAWLNQDRQERPRNVVINAFKGDARWQHANARAKPLGPYWHRAVAIVHRNGLFTLCFQRADGQYSKVTMQLSPPDDILYSHASFAPTVEGKMLITLHSFKKVISVYFLSIDWNEVKQAIEGLPVLTLESISSNVSSQPSGSPTLPDTYDPDSWLLSHLEVVRTSDVEKAVQIPPTILAVSSGVNRTVNIPDSGFLVSSMIKRWSVTPVEQKLHPLFDALPSTGLGATTPKPSYTLQRQPDKEEQVITTIHHVDGVQALVVTTQENRTDFLSSEDLSPMSYTALVQETTSMSQSGFAFPYAQVILTPAFSPNACVRADLTPDGKTQLMAMEYQLGQPQSLQPLDPNVDVAIASLNLTFARACWSNATIDDILMCVSQSIPTELIPTVISTVYRTLFRDNDFVNEKTEGSELEKFIHKTVIGRVLSYHASLAANCSQLPSIASTDRRHGCWSLSAQWAWLVNNIRQTATLLFMAMRDVQNIQLVMSQDLTDLLCANLRWGLSLMRFIISTILEVGDRETNPEMFDEKDPGRAGDSLGDGSQGLVALLLNCHPSRIFLIAFVRAVRAYAKNTEPKSNHHFQVLQCIQQQTSGKGLSFQAMEALLEYRWSAVGDVDRDMAATAVRQLEMMATGIVHESYQGTIKVLLNTLFNSAQGLRAKMLIDRVKLFVDHVDLEYIFLNNDILGRRDSDGDPGKKELVYDVHRKRPILKGVAEPNGSAQLMIRKCLRCGSYSEDVNVPPKEWPRQVAMLLMRCVCDGSWVLKPWDSVHK
Length930
PositionTail
OrganismCladophialophora immunda
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.08
Grand average of hydropathy-0.193
Instability index42.28
Isoelectric point5.81
Molecular weight103948.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02636
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.62|      14|     176|     577|     607|       2
---------------------------------------------------------------------------
  127-  140 (27.67/ 6.74)	VKGRIWIYHNSLLA
  581-  594 (24.95/30.21)	VIGRVLSYHASLAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.42|      32|     157|     684|     718|       5
---------------------------------------------------------------------------
  684-  718 (50.16/50.76)	MFDEKD.PGRAgDSlgDGSQGLVALLLNCHPSRIFL
  837-  869 (54.27/40.69)	IFLNNDiLGRR.DS..DGDPGKKELVYDVHRKRPIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.28|      40|     157|     366|     406|       6
---------------------------------------------------------------------------
  366-  406 (69.12/49.84)	WSVTPVEQKLHPLFDALPsTGLGATTPKPSY.TLQRQPD....KEE
  525-  569 (61.16/39.16)	WSNATIDDILMCVSQSIP.TELIPTVISTVYrTLFRDNDfvneKTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.37|      10|      48|      63|      72|       7
---------------------------------------------------------------------------
   63-   72 (21.44/12.91)	IAWSRH.GHLA
  113-  123 (14.93/ 6.58)	LAWSPNgGELA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.23|      44|     296|     436|     492|       9
---------------------------------------------------------------------------
  447-  492 (72.15/70.01)	VQETTsmSQSGFAFPYAQVILTPAFSPNACVRADLTPDGKTQLMAM
  746-  789 (75.07/43.35)	IQQQT..SGKGLSFQAMEALLEYRWSAVGDVDRDMAATAVRQLEMM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02636 with Med16 domain of Kingdom Fungi
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