<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02625

Description Polynucleotide kinase 3'-phosphatase
SequenceMHEFALYGQVRKDDHHRMLQQLAGFARMQPQDAKEIHLVFKARQPPGVDLVQSIGASHLASQQQQDMQRVKNMLNAGLYYVQLVGEVLPEKQARVAENGDVTMANGNGSHTTEKSSVKWSFEFKDTPDAGKQAVSSRLISRTPMDDGSFVKFLDNFGYEYVSRYLVVGSRFYDHDTTLFLHKVLRLPQIAADEAISDQSFLANVGDLPELDGSGGFVLQASIDVVDGNNPELKERATRQLVAIREALRQAVDLSPGDRLALDTRLPITSHILGRCYTMKRSAPAPAGSVSPPLVKRKIESATTSKAVASFFKPASQKEPEKLVWRTVDHSLIIGRYNVPHKPPQPRTLPVKIAAFDLDDTLVAPNTVNKWARSAVSWKWWDPSIPGRLKSLHDDGYLLVILSNQSAISLKDNPKTLKKDMASLANFKNQASSILKQVDLPISIYAATGQDRYRKPRVGMWEEMLEDYDLQAEGAVDMEHSFYVGDAAGRDKTDKRRKDHATSDRDLAANIGIKFHTPEEFFLDEATEPYEHVFDPTKHLEPAQPSDSTVTGAVEDTVSAPFTKNSPHELVIFCGSPGAGKSTFYWDVLQPLGYERVNQDILKTRDKCIKKAKELLEAGLSVAVDNTNADIETRAYWVRVAQEFNVPIRCVRFTASTRLAEHNDAVRAMNPNTMNPENRTQLPGIAFRSFIQRFQEPTLEEGFEDIYKVEFEFKGTEEQKKLWSRYWVSKFST
Length732
PositionHead
OrganismCladophialophora immunda
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.09
Grand average of hydropathy-0.487
Instability index37.18
Isoelectric point6.47
Molecular weight82273.02
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
kinase activity	GO:0016301	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02625
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.16|      66|     257|      56|     131|       1
---------------------------------------------------------------------------
   56-  131 (99.86/77.19)	ASHLASQQQQDMQRVKNMLNAGLYYV....................................................................................................................................................................................qlvgevLPEKQArvAENGDVTMANGNGSHTTEKSSVKWsfEFKDTPDAGK
  136-  161 (25.89/ 7.30)	SRLISRTPMDDGSFVKFLDNFGYEYV......................................................................................................................................................................................................................................
  348-  387 (60.40/29.93)	..........................srylvvgsrfydhdttlflhkvlrlpqiaadeaisdqsflanvgdlpeldgsggfvlqasidvvdgnnpelkeratrqlvairealrqavdlspgdrlaldtrlpitshilgrcytmkrsapapagsvspplvkrkiesattskavasffkpasqkepeklvwrtvdhsliigrynvphkppqprtLPVKIA..AFDLDDTLVAPNTVNKWARSAVSW..KWWDPSIPGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.04|      13|      19|     198|     210|       2
---------------------------------------------------------------------------
  198-  210 (23.15/15.06)	QSFLANV.GDLPEL
  219-  232 (16.89/ 9.00)	QASIDVVdGNNPEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02625 with Med18 domain of Kingdom Fungi
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