<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02621

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSSSARPTAIPPSPTSPSESGLKRRRLSDNLPQSPISPSFMSVATKSYVSSYGNTHNPDEASGRSSPNSPKASAPRSQQPLSRPMPSLPTPAHSVTGTSSGFDMADDIDQHRDKRPRLDADRDQEADQMEVEPLREATNHDRNDEMEIDGEKLSKGKSAELPEHEQDAELMVDEKTLEQLQKDMGEAFLLCTSKVERQKPNPQQHLLALYGLGPLLHSVARTDPRTGEKINKLRKSYEGQIKGFALAGRNKPVKGERNVEEDEPGPLRRMAGSSPWGLQPDEQWNAEHTKEPPQVTIDFTAELKMAMQMQPGTVRNNAHWEDVLGFDKPKPNVAPEQQPTPRPMANGVVRPPQQPSAEAKRQTRGKKRSYGDDSFVGYGEGYSDPEDGDGDEYGSQRKRKKVTATDY
Length407
PositionHead
OrganismCladophialophora immunda
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.05
Grand average of hydropathy-1.131
Instability index58.78
Isoelectric point5.83
Molecular weight45082.38
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02621
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.80|      33|      51|      13|      60|       1
---------------------------------------------------------------------------
   13-   47 (50.61/21.64)	SPTSPSESGLKRRR.LSDNLPQSPiSPSFmSVATKS
   66-   99 (55.19/31.84)	SPNSPKASAPRSQQpLSRPMPSLP.TPAH.SVTGTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.02|      34|      51|     197|     231|       2
---------------------------------------------------------------------------
  197-  231 (56.25/33.24)	RQKPNPQQHLLALYGLGPlLHSVARTDP...RTGEKIN
  249-  285 (57.78/30.40)	RNKPVKGERNVEEDEPGP.LRRMAGSSPwglQPDEQWN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.64|      15|      16|     116|     131|       3
---------------------------------------------------------------------------
  116-  130 (24.82/11.53)	PRLDADRDQEADQME
  133-  147 (24.82/12.67)	PLREATNHDRNDEME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.09|      12|      26|     306|     318|       4
---------------------------------------------------------------------------
  306-  318 (18.57/13.12)	AMQMQPgTVRNNA
  334-  345 (24.52/12.59)	APEQQP.TPRPMA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02621 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FALAGRNKPVKGERNVEEDEPGPLRRMAGSSPWGLQPDEQWNAEHTKEPPQVTIDFTAELKMAMQMQPGTVRNNAHWEDVLGFDKPKPNVAPEQQPTPRPMANGVVRPPQQPSAEAKRQTRGKKRSYGDDSFVGYGEGYSDPEDGDGDEYGSQRKRKKVTATDY
2) MSSSARPTAIPPSPTSPSESGLKRRRLSDNLPQSPISPSFMSVATKSYVSSYGNTHNPDEASGRSSPNSPKASAPRSQQPLSRPMPSLPTPAHSVTGTSSGFDMADDIDQHRDKRPRLDADRDQEADQMEVEPLREATNHDRNDEMEIDGEKLSKGKSAELPEHEQDAELMVDEKTLEQ
244
1
407
179










Molecular Recognition Features






MoRF SequenceStartStop




1) GLKRRRLS
2) RSYGDDSFVGYGEGYSDPEDGDGDEYGSQRKRKKVTATDY
21
368
28
407