<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02613

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMATNLDYPSNCATNVYTLNDFGEIAYIVCTVATPPSQDPAAFVSTPEATLARLRKTERQFREVSILAALDVDNRQLFTFYKKVEITNAKDQKTLLTKFGYVLRSNTCTIAYKTAARLPDLMKPDQARLYRLFTIAIISSIKVLPNGDTAVQQFDPKLYVARRDVSESEVDRFGPKNIWSLYRIDLQIIPTGQIILTIVKDREHAFRRVLDVGQDFDLRRSAAPGGYPVYLAPLGRVARLVNNTNGATLTTNDYDEGQDIIPSHDVEQEKELWREVLPAWLSEHADISLDSGTITWVEVQVAVYDAEQPPADNTSVSTTPSGMLGPVSWKTLLWPSSLCFVPDNERPGLPEQVGGIQDPIRFVREWLIGTSNDNSNAHDQSHMANLADDDDDDEPLFAETGTFDDPEHFQPFGPPAFPASQTVYPTPPDAIMTHSVPGLSSVDGIAMTPANLPGKSSDSVRRSDMEMHDFDGMNNDSAMSGYYDEDLFDEMPEDQFGPGNPADEPNWDFFDRPGANIKAISATMTDPADVGVKDVDTIMNDIRGDAGTKAPSHENGIDANHVEQSAEVILPSEIIHHQESAGPVDHAEVSGSRKTGKIERGNPQTTQGVALDGGEQSSKRTGPRRRSSIYESVQRSGRPSWRDYKYTANGGFWFDPDPIAFSPNSSLNLSSVIRHSASSSSNDGESSDEDFSSPYRTSNGKKALVPSCAWTEYHPGSPATVTHQSEFDKAAAEADIKQLLAALKPVAIQPTPIVDFPVLDRALQTDEIVDRNFLQVAQIFVDQVSQTSLVPHADQEYKHKTLTDDHFDIIADLGGLGSASSPLTLSQLISLKADTPNVRPQGKISKLQPSQVCMKRAEQPLVASLPILSFWDTLNLQPAHGLKNAIAFCIHPEGEEVADGCSNLLQRMSDTYNSCALGLHSVGRLNNEADDGRISYNTTAEASSTVRQVCQRMGSMLATASDLSGTVLIYMVSEDDSPAAYLEMCKAFNCLFESFATNADKKNITDMALQIIPRRFVASPESLVVPSQQAYLKLALEVYNRLPPIEESRSPAASDAAITLAKAENPVHLQLASTFASPLSNNGDYLHLAYSATPDGRWITAAWADELGYVSLSMSYCTRCKDSIQGRPRQEVFREMWLVSHDLMSKNRRLWRLGIIKHGFYAPAELQEWRQIFESATAVQKRCSPMLLAASPEPELKVFPHTVAGKLVQAGQNIFGTPVSTPQAGVTSPDQHIPATPTPSGSALINAPTPPEPSLDPNVEVDLTLLDPAEESWGILLPYGLNQSKSIMDIRPALVSAVLLKRRGAKVEEGFISLEVSLVYLPPPVSGGLGQAAPDDLLEDIIKQYRGLLTLGVSRGCVDPSKETLPWHIATVVRGSKALAEAM
Length1382
PositionKinase
OrganismExophiala spinifera
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.327
Instability index49.16
Isoelectric point4.89
Molecular weight151218.97
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02613
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     414.69|     108|     539|     277|     388|       1
---------------------------------------------------------------------------
  277-  388 (180.51/109.10)	PAWLSEHadISLDSGTITwVEV..........QVAVYDAEQPPADNTSVSTTPsGMLGPV..SWKTL.LWPS.......SLCFVPDNERPGLPEQVGGIQ..DPIRFVREWLIGTSNDNS.....NAHDQSHMANLADD
  390-  474 (107.20/53.32)	.....................................DDDEPLFAETGTFDDP.EHFQPF..GPPAF...PA.......SQTVYPTPPDAIMTHSVPGLSsvDGIAMTPANLPGKSSDSVrrsdmEMHDFDGMNN....
  821-  930 (126.98/65.38)	PLTLSQL..ISLKADTPN.VRPqgkisklqpsQVCMKRAEQPLVASL...........PIlsFWDTLnLQPAhglknaiAFCIHPEGE.....EVADGCS..NLLQRMSD....TYNSCA....lGLHSVGRLNNEADD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.48|      17|      31|     756|     772|       2
---------------------------------------------------------------------------
  756-  772 (28.14/18.08)	PVLDRALQTDEIVDRNF
  790-  806 (31.34/20.99)	PHADQEYKHKTLTDDHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.01|      58|     537|     628|     754|       4
---------------------------------------------------------------------------
  475-  535 (99.53/33.80)	DSAMSGYY.....DEDLFDEMPEDQFGPGNPADEPNWDFFDRPG..ANIKAISATMtDPadVGVKD...VD
  687-  754 (87.48/41.14)	DEDFSSPYrtsngKKALVPSCAWTEYHPGSPATVTHQSEFDKAAaeADIKQLLAAL.KP..VAIQPtpiVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.73|      28|     540|      37|     124|       5
---------------------------------------------------------------------------
   39-   73 (36.05/18.14)	PAAFVSTPEATLArlrKTERQFREVsilaALDVDN
 1012- 1039 (47.68/43.80)	PRRFVASPESLVV...PSQQAYLKL....ALEVYN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.45|      30|     822|     109|     188|       7
---------------------------------------------------------------------------
  118-  148 (48.83/106.90)	PDLMKPDQARLYR.LFTIAiISSIKVLPNGDT
 1333- 1363 (48.63/ 8.19)	PDDLLEDIIKQYRgLLTLG.VSRGCVDPSKET
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02613 with Med13 domain of Kingdom Fungi
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