<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02610

Description UV excision repair protein Rad23
SequenceMADSKEDLTDKAHFDPNWIAWNGGYLHSNNVLFYFATSPFFDQVSGNQSLFTQWAGTPNQNDILGTRAKFEANLRHQRGIQYVVEHDPLEENVTHDGPNGPEKSNVWVIRKQNRETEADSSVTTLGYYYIVNDVIYQAPPVASIFNYRMLNTVSALETVFSAPADMSFFDVSHGHTYHKPGHKSTSQALNSASQQSKEDTPLPGTQPPAGEKANGTRPQADGEIDGRTLWDALRMTLQHGKEYTDDVSLVGEPGNFRFSKNREAATGQPKSQIQGAATATPTQSRAASAVPAAKSPGAGLVKGSKAGEKTISAVKIRGVKQENQVPRIDTLFLLVCVNPAFASVHVKGSPGLPQWGLVHEQAVVSYGRRRHSQKSIITFTVTYFAAPLPQSLTLPRRLYLLFFVAIQNYNHTAFARHLYRSIHPQPLLDVSCLIKRPDQTRLASRGTMKLSFRDLKQQKFTIDAEPTDTIAQVKEKVAAEKGWDASSQKLIYSGKVLADANTVESYKIEEKGFIVCMVSKPKAAPAAKPAPPSTPAASTSASTPAAPPAPAAPATQPAAAANLPSTPTPGQAAASAPEVERGFNDPSAFLMGSRNEGPIREMEAMGFERSQIDAALRAAFFNPDRAIEYLLNGIPENAGPTEPSTSDTPNRSSATSPPAAAAQTAQPAQTGGDEPINLFEAAAQANQGGRGSGGAGAGATRGAGAAATGAQGANMDLTYLRNSPHFQQLRQIVQQQPSMLEPILQQVAEGNPQLAQMISLNPDQFLQLLAEGHEEGDGAPPMGAGVVTVTPEERDAIERLCRLGFSRDQVIQAYFACDKNEELAANFLFEQPEDDEPGA
Length839
PositionHead
OrganismExophiala spinifera
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.455
Instability index42.15
Isoelectric point5.90
Molecular weight90246.69
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
damaged DNA binding	GO:0003684	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
nucleotide-excision repair	GO:0006289	IEA:InterPro
proteasome-mediated ubiquitin-dependent protein catabolic process	GO:0043161	IEA:InterPro
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02610
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     110.63|      19|      19|     519|     537|       1
---------------------------------------------------------------------------
  179-  197 (24.69/ 9.00)	KPGHKSTSQALNSASQ.QS.....K
  274-  293 (26.62/10.33)	QGAATATPTQSRAASAvPA.....A
  528-  546 (34.88/16.01)	KPAPPSTPAASTSAST.PA.....A
  642-  665 (24.45/ 8.83)	EPSTSDTPNRSSATSP.PAaaaqtA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.41|      16|      19|     735|     750|       2
---------------------------------------------------------------------------
  735-  750 (30.01/14.43)	QQPSM..LEP..ILQQVAEG
  753-  772 (19.40/ 7.24)	QLAQMisLNPdqFLQLLAEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.67|      16|      27|     382|     407|       4
---------------------------------------------------------------------------
  382-  398 (25.66/32.38)	TYFAAPLPQSLTlPRRL
  412-  427 (31.01/11.83)	TAFARHLYRSIH.PQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.54|      18|      88|     595|     635|       5
---------------------------------------------------------------------------
  577-  594 (35.32/22.81)	P..EVE.RGFN....DP...SAFLMGSR
  598-  625 (16.22/41.38)	PirEMEaMGFErsqiDAalrAAFFNPDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.67|      12|      27|     135|     146|       8
---------------------------------------------------------------------------
  135-  146 (22.29/13.16)	IYQAPPVASIFN
  159-  170 (22.38/13.24)	VFSAPADMSFFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.35|      10|     364|     203|     214|      10
---------------------------------------------------------------------------
  203-  214 (17.72/16.85)	PGTQPPAGekAN
  553-  562 (19.63/10.50)	PATQPAAA..AN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02610 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APAAKPAPPSTPAASTSASTPAAPPAPAAPATQPAAAANLPSTPTPGQAAASAPEVERGFNDPSAFLMGSRNEGPIREMEAMGFERSQIDAALRA
2) SLVGEPGNFRFSKNREAATGQPKSQIQGAATATPTQSRAASAVPAAKSPGAGLVK
3) VSHGHTYHKPGHKSTSQALNSASQQSKEDTPLPGTQPPAGEKANGTRPQADGEIDGRTLWD
4) YLLNGIPENAGPTEPSTSDTPNRSSATSPPAAAAQTAQPAQTGGDEPINLFEAAAQANQGGRGSGGAGAGATRGAGAAATGAQGANMDLTYLR
524
248
171
629
618
302
231
721










Molecular Recognition Features






MoRF SequenceStartStop




NANANA