<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02599

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSHTARPAAIPPSPTSPPESGLKRRRLSDILPQSPISPSLMSVATKSYAPPYGHSQHTDEASGHSSPPSPRSAASHSQQASSRMTQSLPTPAHSVTGIPGLDMADDIDRHRDKRPRLDNSRDAHRIDGESFPNATNHDRQDSMDVDVDEDKDAQVVKPAGGSSADEITLEQVQEDMGEPFLLCRSKVERQRPNPQQHLLALYGLGPLLRTVARTDPRTGEKINKLRKSYEGQIKSFGLAGRNKPVKGERNVEEDQPGPLRRMAGSSAWGLQPEEQWNAEHGTSKIGVTPDFRVKLKQAMQMQPGNVRNNAHWEDVLGFDKPKPNTLPTQQKSHPPTPVHVANGIPRQSAQPTAEAKRQTRGKKRSYGDDSFVGYGEGFSDQDDAVDGDEYGGQRKRKKVMMMRAS
Length405
PositionHead
OrganismExophiala oligosperma
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.04
Grand average of hydropathy-1.030
Instability index55.76
Isoelectric point9.09
Molecular weight44563.02
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02599
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.87|      28|      29|      95|     123|       3
---------------------------------------------------------------------------
   95-  123 (45.12/28.62)	VTGiPGLDMADDIDRHRDKRPRLDNSRDA
  126-  153 (46.76/25.81)	IDG.ESFPNATNHDRQDSMDVDVDEDKDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.13|      28|      33|     258|     290|       4
---------------------------------------------------------------------------
  251-  286 (39.20/31.11)	VEEDqpgPLRRmagssAWGLQPEEQWNAEHGTSKIG
  287-  317 (44.93/24.99)	VTPDfrvKLKQ.....AMQMQPGNVRNNAHWEDVLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.93|      24|      54|      11|      35|       5
---------------------------------------------------------------------------
   11-   35 (41.60/20.40)	PPSPTS.PPESGLKRRRLSDILPqSP
   67-   91 (41.32/16.78)	PPSPRSaASHSQQASSRMTQSLP.TP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.14|      26|      32|     338|     363|       6
---------------------------------------------------------------------------
  338-  363 (44.41/25.73)	VHVANGIPRQ.SAQPTAEAKRQTRGKK
  372-  398 (41.73/23.76)	VGYGEGFSDQdDAVDGDEYGGQRKRKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02599 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IKSFGLAGRNKPVKGERNVEEDQPGPLRRMAGSSAWGLQPEEQWNAEHGTSKIGVTPDFRVKLKQAMQMQPGNVRNNAHWEDVLGFDKPKPNTLPTQQKSHPPTPVHVANGIPRQSAQPTAEAKRQTRGKKRSYGDDSFVGYGEGFSDQDDAVDGDEYGGQRKRKKVMMMRAS
2) MSHTARPAAIPPSPTSPPESGLKRRRLSDILPQSPISPSLMSVATKSYAPPYGHSQHTDEASGHSSPPSPRSAASHSQQASSRMTQSLPTPAHSVTGIPGLDMADDIDRHRDKRPRLDNSRDAHRIDGESFPNATNHDRQDSMDVDVDEDKDAQVVKPAGGSSADEITLEQVQED
233
1
405
175










Molecular Recognition Features






MoRF SequenceStartStop




1) ESGLKRRRLSDILPQSPI
2) MSHTARPAA
3) RKRKKVMMMRAS
19
1
394
36
9
405