<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02598

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMATVSEQWTQLLDRCLQRRVRREQFHSLADQLYRRTPIMSAKLSDMLITRQELTPDMFDPLLSVYVETLLEHGRINSADLLAALYRHSKSAIKPESRDLDSTEKKENKVYNTAEFESAVFDMLTRAYLPDGGRPKTQDETRIALVLLSEWLEANISRGTSLADESDHQVLVEAMSVIESFGALSIAMLENARVAGVIDVMLSRDTKKKLAQGLTSFVQFWATAAPQHAANAARLDSAQKNRGLVEDSETEPQDAALDVATAMQIEAIVDMQMVHTRPHTFVFLNALLTGCPLTDESMMMNYLHTRYGGDAQSLTMDLIFAAFDTLAAAAERSDPHHSMFSLKSFLVNKVPLLLSTLSGSLLAPELVIQQALSHVDINVFPTVGLGMLQSNTALQDTRQDFVYACILHGLLTANSVGRLLGESTFDSPPSPSSRLHKDMLSQQCANEPGKVVQLIADLEKLDGNAGAIIGAVVEAIRTACATKDTMSLKSICNAFAGKPHFLDAMLQFTSPASILQPLCQLLETWKYEDDQGESQPVYDEFASVFLLVLTFVYRYGFSHAEAGMPKEAFVFRYVAQNHQEQLSSQMTEEQSRHLGSWVKGLFDPDGITEEVTASCQPQQFYLLVPTIFSQTILACSAGVLSLDTIKTGLEYLQEPFLLPSLVGAIHWITTYVREYPGVNTDIIIQILQRVTRAPSSGEAQAMHTSIMGIVSLPLVHCLRTLRKINSKRVDVDPMLQSLKQYGDFIRSPFGPCTSIAMYSLPQGVKSAVKSAFQGLINWNLQITTLNPAQLPPPYQHRVMLIAEHLIGATEMLSVLLAEIKEQSENAAGAAAVALDIATAIVCAPKAENSPIEIAWPTSPVPAQHPYQNKRLNLREALSLQNERVADIIKKDQSLAETIVRLHRRVEAQCAIGTAPLPDLTGQLPPQDVQQMLDSITTQQNTTQQQPALDLTQDSGLTADLGLNGADSMQLDFSVGNGGDGGMGGLLGGGESMNPDDDVFGDLDLDLSNMESLDIDYGF
Length1017
PositionTail
OrganismVerruconis gallopava
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Venturiales> Sympoventuriaceae> Verruconis.
Aromaticity0.06
Grand average of hydropathy-0.073
Instability index44.59
Isoelectric point4.92
Molecular weight111570.92
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02598
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.03|      22|      22|     947|     968|       1
---------------------------------------------------------------------------
  947-  968 (38.22/22.95)	LDLTQDSGLTADLG..LNGADSMQ
  969-  992 (36.81/21.84)	LDFSVGNGGDGGMGglLGGGESMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.49|      13|      22|     378|     390|       2
---------------------------------------------------------------------------
  378-  390 (23.33/16.36)	VFPTVGLGMLQSN
  401-  413 (23.16/16.18)	VYACILHGLLTAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.67|      11|      18|     550|     560|       4
---------------------------------------------------------------------------
  550-  560 (22.63/17.37)	FVYRY.GFSHAE
  568-  579 (18.03/12.25)	FVFRYvAQNHQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.16|      13|      18|       6|      19|       5
---------------------------------------------------------------------------
    6-   19 (20.58/17.99)	EQWTQLLDRcLQRR
   23-   35 (24.58/14.78)	EQFHSLADQ.LYRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.58|      13|      20|     736|     748|       7
---------------------------------------------------------------------------
  736-  748 (24.40/16.27)	SLKQ.YGDFIRSPF
  758-  771 (17.17/ 9.31)	SLPQgVKSAVKSAF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02598 with Med5 domain of Kingdom Fungi
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