<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02595

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGRLLKMTTNGVEGADHVVNGKQSLPGAVQPANESSIPGLGKRASDNALVNGDSHLPGLGAYPTPNGVSPSSPAKTALPDSMYDLPEEVVHITTGVHSLGALIQRVSAQCFNELEATVDQLARLPLQIPSPMANGAGGIHQTPTLSGKDEERNKQKKGLILKFASDFRAKFIKLLVLTDWAKRDQKDVSKLIDLKNWLVVQDDAALQAGNWFYNIIKDLRSFKLANPDLETALAVLSKGDVPWLPHLDFREQKALSPESTLKVLRQMNAIINLRLVLHEELIPQLRDYRVANGRATFTFPQEFELDVYVASEDPEQPWYFLDVRFLFEPAPQMKGERLRAVVDSRMNMALAENGLKGACELAHDFVLTHKINILRKQAQELQRGIWASSLNVDMIRRTLVVQYWTESPQPKSWIEIGIATGKDKSRRRKADNAISSQVKTRWIRNGKEQKDVEVPIDLANLSLERLLSAYIARHSSHLLESVQEGLETQALNLAHGEERLLKIDLTTSETEPADCVLRARIGGHPTTALQIDGITGRLYFSPAGIATPKAQEALERAKDPATEAPATLLRYLTYDIQLRLERLIDNLGWEAMRHLKITRDDISRRTKREALRFGLYQPRSFKGSHWYIMFTINLCGESWWVLEFDPSSPSNANADVACSRLKVPGTGDLLAPLSVQTLKKLEQSAISASSYIAANRDLTARGVSTAIRHVPIDLSKTPLASSFKSSTAEKTLPTLMIRFSQLLRSTRQGFANDLLQLQYLSFDTDLGQVRLVAKGRMRDPAKVQDVLQKTKDSNVAFSPDGSFSMLLSAKVGVSVVPTIVARLNTLNTLCHFAKILRRSGFECKTISFSKVCFRFAQDQEITLVFAGTEEDPRIKLEIARDNPHRRVAPLLEEIVNDPEMGFERFVLALDYFHPVLRAFQRLEQKHALDYPAAPIIHPRQVDFYRLLYPNPNNPKEPYVIFDLSFKRNKDDLEWRIAEFSNQNAKLEREKVFPNIEAKLSEFMKRVGTGWTGMRSMIIAPHKGGIEEAILELDRCVWDAMGRGTISHSRDGKGIGQDVITID
Length1063
PositionTail
OrganismVerruconis gallopava
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Venturiales> Sympoventuriaceae> Verruconis.
Aromaticity0.07
Grand average of hydropathy-0.305
Instability index45.44
Isoelectric point8.78
Molecular weight119163.19
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02595
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.67|      22|      28|       1|      28|       1
---------------------------------------------------------------------------
    7-   28 (40.00/39.36)	KMTTNGVEG.....ADH.VVNGKQSLPG
   32-   59 (28.11/11.48)	PANESSIPGlgkraSDNaLVNGDSHLPG
   65-   80 (18.55/ 6.37)	..TPNGVSP.....SS....PAKTALP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.70|      24|      27|    1011|    1034|       2
---------------------------------------------------------------------------
 1011- 1034 (43.96/30.09)	WTGM.RSMIIAPHKG.GIEEAILELD
 1038- 1063 (35.74/23.06)	WDAMgRGTISHSRDGkGIGQDVITID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.66|      18|      28|     219|     237|       3
---------------------------------------------------------------------------
  219-  237 (25.98/22.29)	DLRSFKLAN.......PDlETALAVL
  249-  265 (27.46/18.04)	DFREQKALS.......P..ESTLKVL
  285-  308 (18.22/ 9.21)	QLRDYRVANgratftfPQ.EFELDV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.90|      29|      36|     465|     500|       4
---------------------------------------------------------------------------
  465-  494 (42.98/33.86)	ERLLSAYIARHsSHLLESVQEGLETQALNL
  730-  758 (48.91/21.99)	EKTLPTLMIRF.SQLLRSTRQGFANDLLQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.37|      21|     254|     177|     197|       5
---------------------------------------------------------------------------
  177-  197 (37.69/24.00)	VLTDWAK..RDQKDVSKLIDLKN
  439-  461 (33.68/20.72)	VKTRWIRngKEQKDVEVPIDLAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     235.35|      60|     319|     549|     620|       6
---------------------------------------------------------------------------
  549-  613 (85.43/73.32)	PKAQEALERAKDPATEAPATLLRYLTYDIQLRLERLIDNLGWeamRHlKITRdDISRRTKREALR
  873-  930 (95.93/63.30)	PRIK..LEIARDNPHRRVAPLLEEIVNDPEMGFERFVLALDY...FH.PVLR.AFQRLEQKHALD
  939-  975 (53.99/27.81)	PR.QVDFYRLLYPNPNNPKE..PYVIFD..LSFKRNKDDLEW.......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.12|      44|     221|     115|     160|       7
---------------------------------------------------------------------------
  115-  160 (70.17/56.78)	LEATVDqlARLPLQIPSPMANGAGGIHQTPTLSGKDEERNKQKKGL
  339-  382 (70.94/50.66)	LRAVVD..SRMNMALAENGLKGACELAHDFVLTHKINILRKQAQEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02595 with Med14 domain of Kingdom Fungi
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