Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MAPYKASTPRRGAPQAVRASNAQTTNPQSPPNRDKHHRVGTPQRTGAGRSGAGTPTVRAGRVGRGFRNESTQRVVRHQKTPYVYRIGIRLPREKLQQFPWYNGRVRKFLYDGAGSFVTLKIPRLHTILSSSRQGRFPSASAVGQIETAATAVSEATFSPSPGTILSGAPSIFSEVEPCSDFRTPITDESSPQDTWPNVRLRDEWKGAEQELLSATAGSSVAHDHYRPFDHDNKHLTAPGTVEEPFAFPNRSHSDFEDLPVAGRLLSNSNTDGDAMAPVKDTSNVHNTIKDIIQHLTEIQIQTHGYIPATRDLLVDKFSDLTNSLSQLKRLTSPTESPNNYIHQVAIAPEIVDYVDDGRNPDIFTRDFVENVQRGNAVINGKQQAFRDFTEIFAQKLKEGIPGVSREVDRVLRNAGFDEQHDATTNGDEQTPSPQRGEANDNGPANG |
Length | 446 |
Position | Middle |
Organism | Cladophialophora immunda |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.745 |
Instability index | 40.28 |
Isoelectric point | 7.28 |
Molecular weight | 49130.64 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP02586 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 87.91| 27| 27| 12| 38| 1 --------------------------------------------------------------------------- 3- 30 (42.86/19.04) PYKASTPRrGAPQAVRASNAQTTNPQSP 31- 58 (45.05/20.33) PNRDKHHRvGTPQRTGAGRSGAGTPTVR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 185.21| 61| 65| 255| 319| 2 --------------------------------------------------------------------------- 234- 257 (25.51/ 9.24) ....................................HLT.....APGTVEEPFAFPNRSHSDFED 258- 322 (95.31/66.22) LPVAGRLLSNSNTDGDAMAPVkdtsNVHNTIKDIIQHLTEIQIQTHGYIPATRDLLVDKFSDLTN 324- 368 (64.39/36.73) LSQLKRLTSPTESPNNYIHQV....AIAPEIVDYVDDGRNPDIFTRDFV................ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.90| 13| 23| 61| 73| 3 --------------------------------------------------------------------------- 61- 73 (22.77/14.58) RVGRGFRNESTQR 85- 97 (22.13/13.95) RIGIRLPREKLQQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) MAPYKASTPRR 2) PYVYRIGIR | 1 81 | 11 89 |
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