<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02577

Description Uncharacterized protein
SequenceMLQQSSQHRGGGGAHVRVHSNASSRASSTADDARRSGLKSDLDGLRTPYGSDGGPADVDARSEMSAGSAESSVQQVATCTIPPVGFPPRPAQYARNRNALPWPSDAGGDGASGVDGRAQNFEPPLVSLVYPNGKSADYNPWTGNGPEDTLSEQTVKSGFLNKPTITNESNTARPSIWNPLKHKSGLQTLSSLFVAILEKRQGSGRLTATSTFKPPPRVSLTNTKREAWLSDLANPACALRRFNRTIPYGINGKGLLEQCLAKEIPTARAIWLAKCIGANELRTLKRKGVTGALGISAEQKWVREWTMHVEQFIDATISSRSDQSWRVKMQYVVRLTYHLYVEQLLDQDHFLDWIMSSFEGSSVERLPLWLVHVQLYWRFLTSTRKRGRRLAEAVCNSLHQIEADEENADLLAPISQRLRLLLGTLASSHAGCLIIPKSWTRFEPLVRSMTLRADLASAVASIIERNNRLAKPLWEQNPRSTVSPKRRAFEILDKADADASIPEVCSKLYGALSSPEDVVKLVLEWCSSAYRQGSHRVYLASRILRRYALIGVDIEGYILTFIMDPPSNANIDVHNVIKVVAELVRAKSFAVLKVLRAVIARGAMSDSEHSPQSASRLRELVRGIPTVGLPQHVGDLQRNLLREANEPGLSKLQPVAILKERVEEAIFGRSEDKWSEKEEKLLHGLSIAERFELSAFVRNEYSRLTKAYVETGSSLPGSTRPYLTANMFESARYLLETVEDFPILADVIGICLRQCHHDILVAAIDTIRSHIGNFAAIGALRPLVLSAVERYHIFRNEMPLEKGYLSSLLNLLTSVKSELALIQQVTYDLARCDQRNALAICSPASDNALDLVASSSLESEEEIDRILSSGTTMDEQSITRVFQRITTHLTTPLKARVKAQWFPRLRAFDESTFDTLLSEWVTRLLQSMTEDICCKVLTMLLGSGALSFERLSQIERKIREQSVLSTEANCKLSIVVVSVLLLPGNMNKLEDFNVNYKFRLNQKDFTKKHVDTVLQHLAIALSNLDHDSTYPCIDTLEKVLRNDAVKEFLLGCAIDHKRQLQEHVMNRTLTQRGSALLKDIIEELLNHQGQISASLSSQEKIPQLVKMVGELSLPLCQLEMQLLLNNGIRASEGSTEIATSLFEAIMRSPDSERPPWLDLMDGLDPALLVRLRAIAEMQVLKIVNDCCTRIKGEGNDVDHFQLLRIRTLLRRLLYIVDSTVSTQVVPQSVPQTAQGDVDSPVQDRFGMIRELLAKYFAGDVDSRPLSRMASDLSCCLLNALLHLLVVRKLTSESSKSSPADVASLLPILFSVFTHAALSSSRSTTEFLYDTTAYISDELTDEYRNVLIRSEIPKYPNERRVSFILAPPPSVDAWLGLVTTRQQPQTPSTPTTTTIQQAPPARFGAQQGSPRLPLQIPRPPTPQRQSTTATAQPQKSFNAPVPFHLRRWELLPDPGSSTTANDTSISLSLMGARRV
Length1474
PositionKinase
OrganismVerruconis gallopava
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Venturiales> Sympoventuriaceae> Verruconis.
Aromaticity0.06
Grand average of hydropathy-0.223
Instability index50.42
Isoelectric point8.51
Molecular weight163807.35
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02577
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.42|      29|      34|    1363|    1396|       1
---------------------------------------------------------------------------
 1366- 1396 (52.14/35.33)	PPPSVDA.....WLGLVTTRqqPQTPSTPTTTTIQQ
 1398- 1431 (49.28/21.48)	PPARFGAqqgspRLPLQIPR..PPTPQRQSTTATAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.35|      17|      35|    1083|    1099|       2
---------------------------------------------------------------------------
 1083- 1099 (28.07/13.30)	ELLNHQGQISASLSSQE
 1103- 1119 (26.61/12.29)	QLVKMVGELSLPLCQLE
 1121- 1136 (25.66/11.63)	QLLLNNG.IRASEGSTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.66|      27|      38|      48|      83|       3
---------------------------------------------------------------------------
   65-   92 (44.70/24.66)	SAGSAESSVQQVATCTIPP.......vG........FPPRPAQ
  106-  148 (35.96/14.59)	AGGDGASGVDGRAQNFEPPlvslvypnGksadynpwTGNGPED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.30|      27|      38|     454|     482|       4
---------------------------------------------------------------------------
  454-  482 (40.54/32.35)	DLASAVASIIERNNRLAKPLweQNPRSTV
  493-  519 (46.76/29.21)	DKADADASIPEVCSKLYGAL..SSPEDVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.53|      27|      38|     310|     337|       5
---------------------------------------------------------------------------
  310-  337 (44.34/30.53)	EQFIDATISSRSDQSW.RVKMQYV.VRLtY
  348-  376 (42.19/24.36)	DHFLDWIMSSFEGSSVeRLPLWLVhVQL.Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.06|      25|      38|     934|     959|       6
---------------------------------------------------------------------------
  934-  959 (37.94/26.47)	CK....VLTMLLGSGALS.FERLSqIERKIR
  970-  999 (35.13/19.63)	CKlsivVVSVLLLPGNMNkLEDFN.VNYKFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.66|      28|      39|     236|     263|       7
---------------------------------------------------------------------------
  236-  263 (50.20/31.48)	ACALRRFNRTIP.YGINGK.GL.LEQCLAKE
  278-  304 (32.90/18.00)	ANELRTLKRK....GVTGAlGIsAEQKWVRE
  614-  643 (38.57/22.42)	ASRLRELVRGIPtVGLPQHvGD.LQRNLLRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.30|      35|      39|    1176|    1214|       8
---------------------------------------------------------------------------
 1176- 1214 (51.83/45.41)	EMQV.LKIVNDCCTriKGEGNDVDHFQLLR...IRTLLRRllY
 1217- 1255 (48.47/30.14)	DSTVsTQVVPQSVP..QTAQGDVDSPVQDRfgmIRELLAK..Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.79|      24|      39|     795|     818|      10
---------------------------------------------------------------------------
  795-  818 (38.95/28.84)	RNEMPLEKGYLSSLLNLL..TSVKSE
  835-  860 (33.83/23.85)	RNALAICSPASDNALDLVasSSLESE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.59|      21|     181|     533|     553|      14
---------------------------------------------------------------------------
  533-  553 (36.50/24.45)	GSHRVYLASRILR..RYALIGVD
  717-  739 (31.09/19.64)	GSTRPYLTANMFEsaRYLLETVE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02577 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LGLVTTRQQPQTPSTPTTTTIQQAPPARFGAQQGSPRLPLQIPRPPTPQRQSTTATAQPQKSFNA
2) MLQQSSQHRGGGGAHVRVHSNASSRASSTADDARRSGLKSDLDGLRTPYGSDGGPADVDARSEMSAGSAESSVQQVATCTIPPVGFPPRPAQYARNRNALPWPSDAGGDGASGVDGRAQNFEPPLVSLV
3) NGKSADYNPWTGNGPEDTLSEQTVKSGFLNKPTITNE
4) PFHLRRWELLPDPGSSTTANDTSISLSLMGA
1374
1
132
1441
1438
129
168
1471










Molecular Recognition Features






MoRF SequenceStartStop




1) FHLRRWEL
1442
1449