<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02572

Description Uncharacterized protein
SequenceMTSNPPAEPRPPPLRRPPDVPRPSLDRAASDALSSSGRRPAGPQRQYPEPTQDRPTKRRKVEGDGFLNQASSNGNASTATTTQHGASQLRLVPPSASALLFGAHPSQYGKWLEGGADNGVPDLPHRPWDLGRQSKTTEDPLPTHRSRIYVPVPTTPDSLASPERVPHFVPKKAAGFFPWTGKHPEDVLNDVNVKQGYFDKPPNPTEKELNTARVPLYNALKHKSGVDSLSVLFSLILDKKSQQSIINVPTTFKPPPRVTLTEAKRKSWIADLANADVPLRRLSRTIPQGIRGQLLLDQCLQNHVPLSRAIWFAKCVCANEIRTLKRKGTTPAVAMGSEGKWLREWTTSVEQFLESYLGQAGNSDWRSNIQYAIRISTRLYMENLLDRDHYIDWILRSFAAASLQQLPFWLMVSHIYKQDMSYYRRRGRRLAETLIEKYELVRKTAGPGAAPLLQRLHHAIRDLLLSRPRNFLMPDRWPEVYSVVQTCLDGKIQQEKQILEELNRINERTMGFNKGDFCNKRSAVQEIVEVLDTLKPPFDVAKLAANLTTICSDTGVLISTCFEWACTRFRSSDARIHLFARLLRRWQRAGLDVDTIILNYLSSCREGKTTADTQCLRRLVAQLSRSNSFPTAKYLQWLMVRGLPKAGTVTLGQDTGAGTNSISDFSKVNFFLLDLCLQNTGAHVINLRSSILARCGFDLNSEEELYQHHIRYIEQQLSRSFAGASSSTPNISEPSFASLPWSVKSKISVWLRARAVQIAMRDMPGPLTSTRSDCAQFAFIRYILECMGDEPVLADVIGILCNTQDDALMASLTATVQAHSEVLQSIGAFDVLQRRLCQIYMSWRSTKPAMPLFTNFLLDLCSTYPVATPSVKSLQQDFVRGDRGRAVAACSPYSDGIAESLQQAGATFVEDFEAILQSEPNMSEQTMNGLFSVLVDRIEKQQKFGDDSLTLFSFCQLLSRLRLCRKGQADKLIQKWLTRLAPFLDATFGPCLFQNLIGAGCVTFAGFLEAMDLTKLQLRKLPSAATLLRWLHAPDRESLSNLAFYQTRIRWTEYCRGEPQHVLEVLTQLGRPDSQAPLPISLVHSLANDLPLTSTRPSESVTALLLQTLDGFLNLGNATPDAVDLRGLLSGINIFSCRHIQLRLWLTSARTTSEGQGQLVDILTDVLERTLQERDVQQCNVAQLLHTAGSEVANRLRHKVESEFLEALPKFPMGRTSSPLSAVFPSDIQHLSEIVDRAFRVCVKDTSPMTGFMTQLLEKLTQIFKSQNSHVATSNPSSMTGLSGNSVTANHAQMVTSSPNAIANTSEGGAGGSNGWATVNYLDAILYMVCLQRLSLISAGRTGPNTKQGQSEQVQLLVRLALIFTHPAIAALTALSSNKQEQEKVKNVHDFILDVIATIVDQVGDEVKMMCAKLLKDKMHDVRLRYLFGSVNITGSVQVQDMGQGLQMVKEGKGIIGEWRPRVWEVLDNGSGKENETPLGLGLFGARRGRLTED
Length1494
PositionKinase
OrganismExophiala spinifera
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.263
Instability index52.12
Isoelectric point9.00
Molecular weight166249.28
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02572
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     766.04|     216|     227|     765|     990|       1
---------------------------------------------------------------------------
  623-  754 (101.04/65.24)	.....................................................................................................LSRSNSFPTA....KYLQWLMVRGlpkagtvtlgqDTGAGTNSISDFS.K.....VnfflLDLCLQNTGAHVINLRSSIL.ARCGFDLNSEEELYQHHIRYIEQQlsRSFAGASSSTPNISEpSF........ASLPWSVKSK......ISVW.LrAR...........
  768-  990 (332.54/285.79)	TSTRSDCAQFA.FIRYI....LEcMGDEPVLADVIGILcNTQDDALMASLtATVQAHSEVLQSI.GAFD.VLQrRLCQiyMSWRSTKPAMPL.FTNFL...LDLCSTYPVATPSVKSLQQDFVRG...........DRGRAVAACSPYS.D.....G....IAESLQQAGATFVEDFEAILQSEPNMSEQTMNGLFSVLVDRIEKQ..QKFGDDSLTLFSFCQ.LL........SRLRLCRKGQADKL..IQKW.L.TRLAPFLDATFgP
  995- 1225 (265.01/191.36)	NLIGAGCVTFAgFLEAMdltkLQ.LRKLPSAATLLRWL.HAPDRESLSNL.AFYQTRIRWTEYCrGEPQhVLE.VLTQ..LGRPDSQAPLPIsLVHSLandLPLTSTRP..SESVTALLLQTLDG.........flNLGNAT......P.DavdlrG....LLSGINIFSCRHIQ.LRLWLTSARTTSE.GQGQLVDILTDVLERT..LQERD..VQQCNVAQ.LLhtagsevaNRLR..HKVESEFLeaLPKFpM.GRTSSPLSAVF.P
 1227- 1308 (67.46/40.15)	....................................................DIQHLSEIVDR...AFR.V..........CVKDTSPMTGF.MTQLL.................EKLTQIF..K...........SQNSHVATSNPSSmT.....G....L......SGNSVTANHAQMVTSSPNAIANTSEG............................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     224.18|      77|     229|      12|     112|       2
---------------------------------------------------------------------------
   12-  112 (113.53/82.69)	PPLRRPPdvPRPSLDRAASDA...........LSSSGRR.PAGpqrqypeptqdrptkrrkVEGDGFLNQASSNG.NASTATTTQH..GASQLRLV..PPSASALLFGAHpsqyGKWL
  249-  342 (110.65/47.49)	PTTFKPP..PRVTLTEAKRKSwiadlanadvpLRRLSRTiPQG..................IRGQLLLDQCLQNHvPLSRAIWFAKcvCANEIRTLkrKGTTPAVAMGSE....GKWL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02572 with Med12 domain of Kingdom Fungi
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