<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02569

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNTTLEFPSNCSTNVYTLNDFGEIAYIVCTVATPPTQDPSAFITTAENTLARLRKTERQFREASILAALDVEARQLFTFYKKVDITAPKDQKTLLLKFGYVLRSNTCTIAYKTAARLPDLLKPEHARLYRLFITAIVSSIKFVPNGETDLQLLGPNLYLVEQAPLATDVHHFDKVNQWVLYRIDLQVVPSGHIILTIAKDAAFSFVRLPECATKLNWNDHTKSETIAIYLAPIGRIARSTQAKILAHKKLIGTSDNQPNGESQLSNARREAWRELLPSWLKEHMNISIEAMESDWIEIEVPVEEIDHGSTDGQQDNPSPDTVERDSVTWRTILWPADLCFVFSVEEHVAVKATEGKEDPMQFVRDWILGTGGGTSKVEANHQSVVDEDDEPLFAEEGTFDDPVHFHPFGPPAFGPGQTIYPTPPDVGMTHPTPGFSSVDGMAMTPANISRGPAERPQPQDEDMPDFEDDPTTSGLQTFYDEDLFEENPDDNLGAEANGDEPNWDFFDAPGLDPNSTRSASHGRIEEPAVRGETQAGGMMGVNDETAGQGAAAPGPAIVKGENMGSEAATNSPANIRLQHPKDQTEHLTKVPQAKSKERPQPPPTWGPPLWKPESAKESIIEAERGRRSSLYDGLHSLPSVSKHDSRYGAGGDYWFDPTPILSNTKGFSKSNPLFQRPASSSSDSDSLMTSSSNSAEPLSGHYPAQAPARQWTEYHSPSPNAVNRQSEIDKKTIYQDVQQILGVLKPGLVEPPTLSDFRSVNADQRKIPPISTQRYLQIAHVLVEQMSQTTLLPHGEYQGGTQLPPRDQMDVNVDLSGINTSATPSSVFQLTNLKAEQNNGRVQGKVIRIQPDQIRIRRTERPLTASISILNFWDSLNLQPDSGPKDVTTFCIHPSQENVTEGCLNLLQRLAETYTSCSLGTHTIGRLPGFTDNGSISWGPNDLGQHNLLQTCHMVGRALGTTSDVKGTVLVCMTSRNQSATSYLEACIGFFGLFESFTEARTDNQSVSDIALQVIPQNFVANAETLVIPPQTAYIRLAIEVYNRLPPSESPAPPAACSSAVVLSKAENSVHLQLTPTYSSPLEKNGPCLHLAYSISQDRRWLTAAWTDESGRVALSMSYCLRLRPTGKIRPLHDIFQEMWDVSQDLMNKVRGPWRLAVVRHEYYEQPELLDWHQVFENSPASQKRCLLVLLSVQLDPELEIFPPLNHWKSGQTGPQNLYGTPASTPQGSMTSPEQTVPATPTPGGSSFMNAPTPSDPGFDPNNESDLTLVDPSEESWAVILPFGINQTRSLIEIRPSQVTGYLMKRRGTKWEDGYNLIEFSLVTSTIPISNTSSEMSPDELLEDLIKQYRALVTLGATRGCVDPNSECLPWHLATAIRGAQLLGQIM
Length1387
PositionKinase
OrganismCladophialophora immunda
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.07
Grand average of hydropathy-0.442
Instability index51.16
Isoelectric point5.03
Molecular weight153105.81
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02569
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     416.54|      71|      72|     431|     501|       1
---------------------------------------------------------------------------
  314-  384 (89.18/39.98)	QDN.PSPDTVERDSVTWRTILWPADLcFVFSV....EEHVAV...........KAtE..GKED..........PMQ.FVR.DWILGTGGGTSKV........EANHQSV
  385-  458 (94.35/42.74)	VDEdDEPLFAEEG......TFDDPVH.FHPFG....PPAFGP...........GQ.TiyPTPP....dvgmthPTPGFSSVDGMAMTPANISRG........PAERPQP
  459-  533 (100.98/46.29)	QDE.DMPDFEDDPTTSGLQTFYDEDL.FEENP....DDNLGA...........EA.N..GDE.............PNWDFFDAPGLDP.NSTRSashgrieePAVRGET
  534-  601 (70.90/30.19)	QAG.GMMGVNDETAGQGAAA.........PGPaivkGENMGS...........EA.A..TNSP...anirlqhPK...DQTEHLTKVPQAKSK...........ERPQP
  602-  681 (61.13/24.97)	PPT.WGPPLW.KPESAKESIIEAERG.RRSSL....YDGLHSlpsvskhdsryGA.G..GD..ywfdptpilsNTKGFSKSNPLFQRPASSS.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     182.97|      44|     328|     870|     933|       2
---------------------------------------------------------------------------
  870-  915 (74.51/34.56)	LNFWDSlnLQPDSGPKDVTTFCIHPSQENVTEGCL.NLLQRLAETYT
 1205- 1242 (60.59/21.57)	LNHWKS....GQTGPQN.....LYGTPASTPQGSMtSPEQTVPATPT
 1274- 1306 (47.87/36.39)	EESWAV..ILPFGINQTRSLIEIRPSQ..VT.G...YLMKR......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.27|      46|     491|     209|     312|       3
---------------------------------------------------------------------------
  144-  198 (63.62/97.67)	PNGETDL.........QLLgPNlYLVEQAPLATDVHHFDkvnqWVLYRIDLQVVPSGHiilTIA
  258-  312 (75.66/47.59)	PNGESQLsnarreawrELL.PS.WLKEHMNISIEAMESD....WIEIEVPVEEIDHGS...TDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     223.04|      68|     328|     750|     824|       4
---------------------------------------------------------------------------
  750-  824 (104.06/82.42)	EPPTLSDFRSVNADQRKIPPISTQRYLQIAhvlvEQMSQ.TTLLPHGEYQGGTQLpPRDQMDVNVDLsgINTSATP
 1085- 1153 (118.99/73.27)	NGPCLHLAYSISQDRRWLTAAWTDESGRVA....LSMSYcLRLRPTGKIRPLHDI.FQEMWDVSQDL..MNKVRGP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.56|      38|    1217|      95|     134|       7
---------------------------------------------------------------------------
   95-  134 (60.58/44.67)	LLKFGYVlrSNTCTIAYKTAARLPDLLKPEHARLYRLFIT
 1317- 1354 (61.98/39.50)	LIEFSLV..TSTIPISNTSSEMSPDELLEDLIKQYRALVT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02569 with Med13 domain of Kingdom Fungi
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