<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02568
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MHEFALYGQVSKDAHHQVLQQLAGYTRMQPQKVVEVHLIFKARSPPGLDNIPSAGGSQGIMQPEVQKIRAMLNGSLYYVQLVGEVALGDTKNQLDGDVTMTTNGSGDPSVSQTKIKWTFEFKDTPEAGKQAVSTRLIHKVPLEDGDFVQFLNAFGYDYVSRYLVVGWNFYDQDTTLSVHKVVLLPQAVAESAMNDTTFLSDISKLKDLDQSGGYIMQTTVEVVDGNAPELKEKGTRQLLAHKEALKQAVDLTPGDRLALDTRVPVTGRR |
Length | 269 |
Position | Head |
Organism | Exophiala spinifera |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.326 |
Instability index | 29.62 |
Isoelectric point | 5.80 |
Molecular weight | 29693.31 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP02568
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 108.34| 30| 48| 95| 124| 1
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95- 124 (55.55/45.17) DGDVTMTTNGSGDPSVSQ.TKIKWTFEFKDT
144- 174 (52.79/42.54) DGDFVQFLNAFGYDYVSRyLVVGWNFYDQDT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 104.87| 34| 154| 30| 66| 2
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30- 66 (51.88/46.26) PQKVVEVHL...IFKArSPPGLDNIPSAGGSqgIMQPEVQ
185- 221 (52.99/35.22) PQAVAESAMndtTFLS.DISKLKDLDQSGGY..IMQTTVE
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