<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02565

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSYSSQSTAIPPSPTSPPQSGLKRRRLSDHLPQSPISPSYMSVATKSYVSPYGNAQHTDEVTGHSSPRSPRGAPPRSQQSSSRMTPSLPTPAHSVTGNSGLDMADEADQHRDKRPRFDDTRNDEGDEMEVEPLTRAANHDRLDVMDTDDAKAGSAYTGQHERGGTSVHETTLEQIQKDMGEAFLLCRSKVEPQRPNPQQHLLALYGLSPLLRSVARNDPKTGEKINKLRKSYEGQIKSFGLAGRNKPVKGERNADEDQPGPIRRMVGSLPWGLQPDEQWSEEHGGSKIEVTPDLKARLKEAMHMQPGTVRNNAHWEDVLGFDKKPNVVPAQPLINPPAVPRVPNGIPRQPGQPSAEAKRQTRGKKRSYGDDSFVGYGEGYSDPEDGGDTDEYGGQRKRKKDLVGTPVTYGQYQGR
Length415
PositionHead
OrganismExophiala sideris
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.05
Grand average of hydropathy-1.097
Instability index57.67
Isoelectric point8.39
Molecular weight45677.98
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02565
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.11|      13|      16|     325|     338|       1
---------------------------------------------------------------------------
  325-  338 (22.58/14.34)	PNVVPAQPlINPPA
  343-  355 (27.53/13.61)	PNGIPRQP.GQPSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     122.34|      16|      16|      67|      82|       2
---------------------------------------------------------------------------
   11-   25 (25.13/10.36)	PPSP.TSPPQSGLKRR
   32-   47 (24.59/ 9.99)	PQSPISPSYMSVATKS
   48-   63 (22.34/ 8.39)	YVSPYGNAQHTDEVTG
   67-   82 (27.48/12.03)	PRSPRGAPPRSQQSSS
   86-   99 (22.80/ 8.71)	PSLP..TPAHSVTGNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.46|      21|      24|     100|     122|       3
---------------------------------------------------------------------------
  100-  120 (38.36/29.32)	GLDMADEADQHRDKRPRFD..DT
  125-  147 (32.11/16.29)	GDEMEVEPLTRAANHDRLDvmDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.23|      22|      25|     184|     206|       4
---------------------------------------------------------------------------
  184-  206 (35.30/22.77)	LLcRS..KVEPQRPNPQQHLLALY.G
  210-  234 (28.94/13.30)	LL.RSvaRNDPKTGEKINKLRKSYeG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.05|      15|      16|     384|     398|       6
---------------------------------------------------------------------------
  384-  398 (26.56/14.04)	EDGGDTDEYGGQRKR
  401-  415 (25.49/13.19)	DLVGTPVTYGQYQGR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02565 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FGLAGRNKPVKGERNADEDQPGPIRRMVGSLPWGLQPDEQWSEEHGGSKIEVTPDLKARLKEAMHMQPGTVRNNAHWEDVLGFDKKPNVVPAQPLINPPAVPRVPNGIPRQPGQPSAEAKRQTRGKKRSYGDDSFVGYGEGYSDPEDGGDTDEYGGQRKRKKDLVGTPVTYGQYQGR
2) MSYSSQSTAIPPSPTSPPQSGLKRRRLSDHLPQSPISPSYMSVATKSYVSPYGNAQHTDEVTGHSSPRSPRGAPPRSQQSSSRMTPSLPTPAHSVTGNSGLDMADEADQHRDKRPRFDDTRNDEGDEMEVEPLTRAANHDRLDVMDTDDAKAGSAYTGQHERGGTSVHETTLEQIQKD
239
1
415
178










Molecular Recognition Features






MoRF SequenceStartStop




1) QSGLKRRRLSDHLPQSPISPSYMSVATKSYV
2) VGYGEGYS
3) YGGQRKRKKDLVGTPVTYGQYQG
19
374
392
49
381
414