<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02563

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMFSPPRPSAIPPSPTSPPKSGLKRRRPSDIDSIPQTPISPPFMSVATKSYVSAYGNSHNTDDVSGRSSPQSPALSGPRAVSSSHNNPRSATSIPTPANSVTGIPGLEMIEDNDQHRDKRARLDHDGDEDMSRMEIDSTTQPTNHDRQDSRDMDGQQGQNSGFTDGRSQTAMQQQKDLGEPFLLRRSKIRAQGPDPQQHLLAMYGLGPLLRSVARTDPKTGEKINKLRKSYEGQVKMFGLAGKTRTIKGERNVDEDQPGPLRRMVGSTAWGLETDEQWNATHGSSKIEVTADFKSKLKQAAQIQPGLCANNQWWENELGLADRPRIPPTVQQPPVSALGPSRIPNGVQRPLPGQAGEAKRSTRGKKRSYSDDSFVGYGEGYSEGEDAGTGDEYGGTRKRRKVMSMIPEG
Length408
PositionHead
OrganismExophiala mesophila (Black yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.05
Grand average of hydropathy-1.012
Instability index60.66
Isoelectric point9.33
Molecular weight44561.93
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02563
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.73|      25|      25|      53|      77|       1
---------------------------------------------------------------------------
   24-   44 (26.15/ 9.78)	RRRPS.DIDSIP..QTPISPP.fMS...
   53-   77 (47.04/23.46)	AYGNSHNTDDVSGRSSPQSPA..LSG.P
   79-  104 (30.53/12.65)	AVSSSHNNPR.SATSIP.TPAnsVTGiP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.76|      14|      15|     323|     336|       2
---------------------------------------------------------------------------
  323-  336 (30.09/13.19)	P.RIPPTVQQP.PVSA
  339-  354 (20.67/ 6.89)	PsRIPNGVQRPlPGQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.22|      25|      25|     180|     204|       3
---------------------------------------------------------------------------
  180-  204 (47.56/22.82)	PFLLRRS.KIRAQGPDPQQHLLAMYG
  257-  282 (38.66/17.41)	PGPLRRMvGSTAWGLETDEQWNATHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.16|      17|      26|     109|     128|       4
---------------------------------------------------------------------------
  109-  128 (27.73/20.28)	IEDNDQ...H..RDKRarlDHDGDE
  135-  156 (22.43/ 9.67)	IDSTTQptnHdrQDSR...DMDGQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02563 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELGLADRPRIPPTVQQPPVSALGPSRIPNGVQRPLPGQAGEAKRSTRGKKRSYSDDSFVGYGEGYSEGEDAGTGDEYGGTRKRRKVMSMIPEG
2) FGLAGKTRTIKGERNVDEDQPGPLRRMVGSTAWGLETDEQWNATHGSSK
3) MFSPPRPSAIPPSPTSPPKSGLKRRRPSDIDSIPQTPISPPFMSVATKSYVSAYGNSHNTDDVSGRSSPQSPALSGPRAVSSSHNNPRSATSIPTPANSVTGIPGLEMIEDNDQHRDKRARLDHDGDEDMSRMEIDSTTQPTNHDRQDSRDMDGQQGQNSGFTDGRSQTAMQQQKDLGEPFLLRRSKIRAQGPDPQQHLLAMYGLGPLLRSVARTDPKTGEKINKLR
316
237
1
408
285
227










Molecular Recognition Features






MoRF SequenceStartStop




1) EPFLLRRSKIR
2) GDEYGGTRKRRKVMSMIPE
3) IDSIP
4) KSGLKRRRP
5) VGYGEGYSE
179
389
30
19
374
189
407
34
27
382