<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02560

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMRWNRSKIAWSRFGCIASVAEDARHINLRVLMRNPKSGEWTLPKPTEIWPSMPDSHEIVHLAYSAMGNDLAVVDSGGRIMLYTTGLTLGSMIPVHVALNDSSDEMNTIVGMHWLPVFLHNSKVFSFFFRSASRNSDTWTAKIQQYHTPGPHNPLEGKSALVCLTRKGTLRLLWQARNNQWSETTVELEDASLATSCSFTHASFSPENDGLLLIAHQLCRATRLYQLRINWNMPPKQENDSQNLTALPNPVLDVRSLLEEHFMSPQNLPNHSQDDTLATTNGNNVDSMYEFHLAKLLFVPPAPDQGTKEPTLQTILAVFTIVPPSHEGMMVDPSQRWGLASTIISRWEVQRDVGDNLSTCFDQLSVKKKAAAGVPLKHGTRLKRLDDVVVSPAVLMITPVRNNTMFALTLSDGSVQFRYRNTMDVVLPDESPDEVQSLTQSGFSFHHIDPCLHTAFSPSACVLATLTAEGQVKLEKMQYTNSSLNDIDENDSKHDAIAAIIALQYSSACMQYKVTDDILAILPANLGTSLTRMIVALCMRFLNVEFDVISGDYQQQILPLFRNHLSFRCFSLQNALGAADKTGPRKLSARLAWITLNLRHVSQSIFFHLRSDQALKYDSAISFVGLFKWYLDLCCYLLQELNSLHYAIKHEAHLGRPGREKDRDWIQEQIQKRHSPAMILLLSSMPRVFLRMTFRPLRHGYMHASNGFRSSTAMEQKNAFHKLLNTFHNSPVNQQSFGALEDFINEIDISIKNAYKTASLSVQDRSAIEKDMLLTLRIPPVLMPTVTAILTVSLDGLMSKVDPGKVHIHDISWLGLTDDHRTKKFNESRTIDVIRKVPLVSTVKLRVCPRCGSVMEDLAHGVGHHQPWVLQSHKICVCLSSWANPDGN
Length887
PositionTail
OrganismVerruconis gallopava
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Venturiales> Sympoventuriaceae> Verruconis.
Aromaticity0.08
Grand average of hydropathy-0.189
Instability index48.38
Isoelectric point7.67
Molecular weight99754.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02560
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.62|      28|      28|     234|     261|       1
---------------------------------------------------------------------------
  234-  261 (48.45/30.49)	PKQ.ENDSQNLTALPNPVLDVRSLLEEHF
  264-  292 (47.17/29.48)	PQNlPNHSQDDTLATTNGNNVDSMYEFHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.54|      45|     331|       2|     145|       2
---------------------------------------------------------------------------
   75-  123 (74.63/154.73)	SGGRIMLYTT..GLTLGSMipvHvALND..SSDEMNTIVGMHWLPVFLHNSKV
  683-  731 (75.91/10.64)	SMPRVFLRMTfrPLRHGYM...H.ASNGfrSSTAMEQKNAFHKLLNTFHNSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.98|      11|      28|     508|     518|       4
---------------------------------------------------------------------------
  508-  518 (21.05/12.61)	CMQY.KVTDDIL
  537-  548 (16.93/ 8.92)	CMRFlNVEFDVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.61|      18|      21|     299|     319|       6
---------------------------------------------------------------------------
  299-  316 (32.03/23.41)	PPAPDQGTKEPTLQTILA
  322-  339 (35.58/17.52)	PPSHEGMMVDPSQRWGLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.22|      14|      21|     783|     796|       8
---------------------------------------------------------------------------
  783-  796 (22.93/13.25)	PTVTAILTVSLDGL
  802-  815 (27.28/17.10)	PGKVHIHDISWLGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02560 with Med16 domain of Kingdom Fungi
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