<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02555

Description Uncharacterized protein
SequenceMTSIPPAEPRPPRRPPDPGRPFLDRVQSDVLSPIGRRPPVAPRQLTEPGHDRPAKRRRLEGDVTGTVAAANRNHGTSTTTTTSDTKTSRLRLVAPSALGLGIGNLRDEKQKEEATDDNEVPDLPGRPWTLSQPSKPTEEPQPSHRRRVHVPVPTTPDSLATPASVPSLVPNKVAGFFPWTGKHPEDVLNDTNVKQGYWDKPPNPTEKELNTARVPLYNAFKHKSGVEQLSVLFSLVLDERSKHGHISSASTFKPPPRVTLTEAKRKSWIADLANADVPLRKLSRTIPQGIRGQLLLDQCLQNYVPLSRAIWFAKCVCANEIRTLKRKGTTPAVAMGTEGKWLREWTVSVQQFVESHLAQVKRLDWRGNIQYAIRLTTRLYMENLLDRDHYLDWVLRSFANADLEQLPFWLMVTHIFRQDLSYYRKRGRKLAETLLQKYESLRISPSQTVVPVLQRLRTAIRGLLLSRPRNFLMPDRWPEIAPIVRTCFDTRIQQERQILDELERINRKAMGYNKLECSAQRTPEQAIVETLDSIQPPYDLAKLADELTRICPDSDFLITTCLEWACTRFRQSKAQIYILARLIRRWQRIGHDTDALILNYLSVYREGKTSTDPQTLKHLIGQLSRSNSLSASKYLQWLMVRGLPKQGTVKLEVASNTHAEEYVHTNPADFLLDVSCQNVEEHVVNLRNSILERAGFDLQLESELYTQCIEFAEQHLAQLGARSAYGRRSVPEPTFGSMPWSVKSKVSMWLRTRVMRSTTHFVSRDPATTILPPFGMLNVEQFALVRHVLECMDDESVLADVVGILCCAQNDELVAALAATIQFHADSFSAIGALEVLQKRMYQIYINWRATKPAMPLLTNALLDLCTAIPIKPPALKLLQQDFVRGDRGRAVAACSPYSDGIAESLQQAGATFVEDFEAILQSEPNMTEQTMNGLFSVLVDRIEKQQKFGDDSSMMFSFCQLLSRLRLCRKTQADLLIQKWLARLGPMLDGKFGSFLFQNLIGTGCVGFAAFLEGIGVAKLGLRKLPAATALLRRILARGGDPLADLAVYQTRTRWFEYCQQHPKSALQVACDAGLENVHPFEACRLSSLLLDGTLTSSPFSEQASRTLLKELNRLLHCRHGGLTGADLRTLLGSVTVFSHRYVHLRFWLTLQVQAENHPAADAGELVQILSDALEKTVSRAGGSQADDARFAQLLDAVGPDIANRLRHRVENEFLEALPKLPIGKTTSPLAAAFPAAINQLSSTVDRAFLVCTKGTSPMPGFLVHLIERLSHVMRVQTHTVSTPTSATVSGVSGSAMSMNPAQLMSVTSSPMANTSSEAVSGSPPSAVSDQLNYILQMICLQRLAIVAAGRNGPNARQGQSEQIQLLARLAQIFALSKFASATQFRDKEEQRKTKELHDFILDVLSTIVDEVSDEVRIMCAKLLRDKIQDEKLRYVFGSANLTGSVQAQDMGQGLQLVKEGKGLLGDWKPRVWEVLDNGSTKENETSLGLGLFGCRRILEAIN
Length1504
PositionKinase
OrganismExophiala sideris
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.263
Instability index47.90
Isoelectric point9.02
Molecular weight167884.73
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02555
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.88|      25|      30|       6|      34|       1
---------------------------------------------------------------------------
    6-   30 (50.84/17.00)	PAEPRPPRRPPDPG..RPF.LDRVQSDV
   36-   63 (38.04/14.85)	RRPPVAPRQLTEPGhdRPAkRRRLEGDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.33|      27|      28|    1273|    1299|       2
---------------------------------------------------------------------------
 1273- 1299 (46.48/34.57)	HVMRVQTHTVSTPTSATVSGVSGSAMS
 1304- 1330 (45.85/33.99)	QLMSVTSSPMANTSSEAVSGSPPSAVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.41|      14|      26|    1090|    1115|       3
---------------------------------------------------------------------------
 1092- 1110 (20.22/33.39)	LDGTLTSSPFseqasRTLL
 1120- 1133 (25.19/ 7.91)	RHGGLTGADL.....RTLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.94|      23|      25|     262|     286|       4
---------------------------------------------------------------------------
  239-  259 (26.92/14.16)	..ERSKHGHISS..ASTFKPPPR...VT
  260-  285 (29.04/22.38)	LtEAKRKSWIAD..LANADVPLRklSRT
  286-  309 (21.98/10.07)	IpQGIRGQLLLDqcLQNY.VPL...SRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.77|      22|      27|     112|     136|       5
---------------------------------------------------------------------------
  112-  134 (38.32/20.25)	EEATDDN....EVPdLPGRPWTLSQPS
  138-  163 (35.45/17.21)	EEPQPSHrrrvHVP.VPTTPDSLATPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.96|      23|      26|    1221|    1243|       6
---------------------------------------------------------------------------
 1221- 1243 (38.87/22.46)	K..LPIGKTTSPLAAAFPAAINQLS
 1248- 1272 (35.09/19.54)	RafLVCTKGTSPMPGFLVHLIERLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.99|      14|      26|     352|     365|       7
---------------------------------------------------------------------------
  344-  363 (17.53/ 8.06)	EW........tvsvqqFVESHLAQVKRL
  364-  391 (16.46/ 7.12)	DWrgniqyairlttrlYMENLLDRDHYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.53|      12|      26|    1162|    1174|       8
---------------------------------------------------------------------------
 1162- 1174 (15.75/14.34)	ADAGELVQILsDA
 1187- 1198 (20.78/13.30)	ADDARFAQLL.DA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.74|      18|      26|    1342|    1359|       9
---------------------------------------------------------------------------
 1342- 1359 (30.83/18.33)	LQRLAIVAAGRNGPNARQ
 1368- 1385 (28.91/16.74)	LARLAQIFALSKFASATQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.83|      12|      18|     651|     663|      10
---------------------------------------------------------------------------
  651-  663 (16.16/16.61)	LEVaSNTHAEEYV
  672-  683 (21.67/16.18)	LDV.SCQNVEEHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.15|      35|      35|     569|     603|      11
---------------------------------------------------------------------------
  538-  562 (36.83/24.81)	............YDLAKLADELTRICPDSDFLITTCL
  567-  601 (61.19/47.29)	TRFRQSKAQI..YILARLIRRWQRIGHDTDALILNYL
  602-  625 (21.14/10.33)	SVYREGKTSTdpQTLKHLIGQLSR.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.72|      19|      27|     487|     506|      13
---------------------------------------------------------------------------
  487-  506 (28.53/22.63)	CFDTRIqQERQILDELERIN
  517-  535 (32.19/20.41)	CSAQRT.PEQAIVETLDSIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.67|      17|      27|     866|     884|      16
---------------------------------------------------------------------------
  866-  884 (27.12/26.11)	CTaiPIKPPALKLLQQ...DFV
  895-  914 (24.55/15.53)	CS..PYSDGIAESLQQagaTFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.64|      16|      20|     175|     193|      17
---------------------------------------------------------------------------
  175-  193 (23.03/25.33)	GFfpWtGKHP...EDVLNDTNV
  196-  214 (24.61/13.75)	GY..W.DKPPnptEKELNTARV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.68|      10|     229|     409|     418|      19
---------------------------------------------------------------------------
  409-  418 (21.02/12.04)	WLMVTHIFRQ
  637-  646 (20.65/11.70)	WLMVRGLPKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.17|      15|      15|     785|     799|      22
---------------------------------------------------------------------------
  785-  799 (27.22/18.28)	VRHVLEC.MDDESVLA
  801-  816 (22.95/14.22)	VVGILCCaQNDELVAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02555 with Med12 domain of Kingdom Fungi
Unable to open file!