<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02553

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVDGMATSLDFPHNCSTNVYTLNDFGEIAYIVCTVATPPTHDPSAFVSTPENTLARLRKTERQFREASILAALDVEARQLFTFYKKVDIANAKDQKTLLTKFGFVLRSNTCTIAYKTAARLPDLMKPEQAKLHRLFSTALISSIKLLPNGDSALQAFGPNLYMVERFPANSEDEGFASPKRWALHRIDLQIIPSGHIILTIAKERRQTFRQALDIEHDVQLAEHAKSSGAAVYLAPVGRVARFVGLPQGHDFNSGQSDHQNLDARLKLWRELLPAWMRNSLNNNAQVQDNCWIEAQIAVQETDRASTDDDSKSVSSVNSGNNASISWRTIFWPANLCFLLESKEPPALQAFGDNHDPLKFIQDWVAGVAQERLGDGEHQHELMNMAEEDDEPLFADNGTFDDPEPFQPSGPPAFPGNQSIYPTPPDVVMTHPTPGISSVDVMGMTPANLPGQSDTAQQLDEEMHDIEEAHTSSEMRAYYDEDLFEEMPEDQFGQEDTADEPNWDFFDQSGMETKPNPTTGSNPPNHLSRQEDAATPNVTHQAHQALREDGTQNTPAPSQRPATVLHDSPLPVESSGLRDTSHPMAPPQAEESMSEAPVKLEQQHDTFAHSTQSAGETDQKVRANGTNTHRHFSIYNGVHPPAEINRDNRYTANGEFWFDPDKTTLQSSRNPYKLTAKVNRPQSDSDDSDSSMESTSRSEEHNPNQNEQPTTLRPWTEYHPQSPSVTTHRGEVERTSVKQEIQELLDLLKPRSMQPPPLIRSETQNRVASVGQLTGQKFSQVANIMVDQYSQTSLISHKQIDADNEGSSAARIEIVADLSGINSSTNASTLAQLVSLKADHTKTRGRITNLKPDQICIRRGDQRLLASVSILPFWNTLNLQPENGSKDVTVFCLHPAGEDVADGCSNLLQRMSDTYNSCLLGSHAIGLLKGVTSTGLIAWDPKSTTSIAHTCQKVGTAIGAADNLSGTALVYMVSQDDSPASYLEVCQAFHGLFESFAAAANKQHISDIALQVVPRGFVASSESLVVPNQIAYIKLAIEVYNRLPPPQPKGSPAACDTAIVLSKVENTVHLQLASAYGSPLSAHGIILHLAYAITADKRWITAAWTDELGQVALSMSYCARRLGSSKKRPRREIFREMWHVSHDLASKHRGRWRLAIVKHGYLDTMEPVEWYDVFGSSTPAQQRCLPLILTMQLDPVYRLFPQPHQGKVGQTGLQNVYGTPVSTPQGGITSPDQLMPATPTPGGTSMMNASTPPEPGIDPNVDGDLSLVDPAEESWGVVLPYGVNQSKNMSVLLPAGVTGLLVKRRGPKVEDGHLSIEVNLLDCTVHVGPDTSKEPSPDELLEDVIRQYRGLLTLGVTRGCIDPLSECVPWHIATVIRGNGALGSVM
Length1386
PositionKinase
OrganismExophiala sideris
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.06
Grand average of hydropathy-0.459
Instability index49.03
Isoelectric point5.27
Molecular weight152271.55
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02553
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     338.94|     113|     193|     228|     420|       1
---------------------------------------------------------------------------
  228-  357 (174.68/234.70)	SGaAVYLAPVGRVARF..VGLPQGHdfNSGQSD.HQNLDARLKLWREL.LPAWMRNSLNNN..AQVQdncwiEAQIAVQET.DRASTD..DDSKSVSSVN..SGNNAsiswrtifwPANLCFLLESKEPP.......ALQAFGDNHDP
  425-  555 (164.26/84.19)	PD.VVMTHPTPGISSVdvMGMTPAN..LPGQSDtAQQLDEEMHDIEEAhTSSEMRAYYDEDlfEEMP.....EDQFGQEDTaDEPNWDffDQSGMETKPNptTGSNP.........PNHLSRQEDAATPNvthqahqALREDGTQNTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     110.68|      18|     187|     559|     576|       6
---------------------------------------------------------------------------
  559-  576 (31.05/17.06)	QRPATVLH.DSPLPVESSG
  679-  696 (26.88/13.63)	NRPQSDSD.DSDSSMESTS
  712-  730 (26.87/13.62)	LRPWTEYHpQSPSVTTHRG
  754-  771 (25.88/12.81)	QPPPLIRS.ETQNRVASVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.17|      28|     198|    1143|    1171|       7
---------------------------------------------------------------------------
 1143- 1171 (48.55/38.37)	DLASKHRGRWRLAIVKhGYLDTM.EPVEWY
 1343- 1371 (49.62/33.51)	DVIRQYRGLLTLGVTR.GCIDPLsECVPWH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.75|      56|     620|     155|     226|      12
---------------------------------------------------------------------------
  155-  226 (69.53/89.54)	QAFG..PNLyMVERFPANS.........EDEGfASPKRWALhRIDLQIIPSGhiilTIAkerrQTFRQALDIEhdvqlAEHAK
  776-  842 (81.22/52.53)	QKFSqvANI.MVDQYSQTSlishkqidaDNEG.SSAARIEI.VADLSGINSS....TNA....STLAQLVSLK.....ADHTK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02553 with Med13 domain of Kingdom Fungi
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