<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02552
Description |
Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MAPRGRVIILRRGGSAPGDRATTNNHDEAYTPPNHGNAGPSRILSRGGGARGRPRGRGQNAYHPQSVHQRQHQQHPTDTQRSTTIHLSPEALREFPPGSCGPFITLKLQKRDPQAAQGPRKFFSESPPVLSSGDTSSHTDQGTSPETPAPDSCSPDFVQRIDLADTDTTHSQPSQRTVGPELAAVTVNNSNSIGLGQGVAAIGDPRQVPPTDTTMAPVKDTSNVHITIKDIIQHLSEIQIQTHGYVPETQDLMVDKMTDLAQSLARLQSLTSPHTSPNNHIHNISIAPEIVDYVDDGRNPDIFTRDFVENVQRGNAVINGKQQAFREFTEIYAKALKDGVPGVRRQVDRVMENAGFQTEHGDEANGARPTESHS |
Length | 374 |
Position | Middle |
Organism | Exophiala sideris |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.786 |
Instability index | 51.48 |
Isoelectric point | 6.37 |
Molecular weight | 40630.26 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP02552
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 203.87| 51| 53| 73| 125| 1
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17- 70 (60.21/24.38) ...PG.D..RATTNN.HDEAYT..P.PnhGNAGP.SR.ILSRgggARGRPrgrgQNAYHPQSVHQR
73- 125 (89.15/43.27) QQHPT.DTQRSTTIHLSPEALRefP.P..GSCGP.FI.TLKL...QKRDP....QAAQGPRKFFSE
128- 176 (54.51/21.53) PVLSSgDTSSHTDQGTSPET....PaP..DSCSPdFVqRIDL...ADTDT....THSQPSQR....
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 79.03| 26| 31| 214| 239| 2
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214- 239 (42.58/23.65) TMAPVKDTSNVHI.TIKDIIQHLSEIQ
242- 268 (36.45/19.38) THGYVPETQDLMVdKMTDLAQSLARLQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.63| 13| 31| 301| 313| 3
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301- 313 (23.33/13.83) DIFTR...DFVENVQR
330- 345 (18.29/ 9.56) EIYAKalkDGVPGVRR
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