<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02550

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEEDLADLDQSDQFASEAFFNQNSLQQQIQQLDPINNLGASANVTPATNPALLEQLQRRWYCGCLARVAWSRHGHIATISNDGSNVHIECIRYDGTSHSYKLHDRLTLPTLFEDAVCLAWSAHGGELAIIDGKGRIFIYHTSLVAINSLTLARSGSLDQVSDTSQPIGVAWLNQDRQDRPKNVVLHATKNDTRWTHNNARAKPLAPYWARALLLAHRNGMLTLCFQRTRSPYAIITQRVSTSDDTLYSHASFAPTVEGRMLIAFHSLKGQISISLLSMDWSGVGEYEGFPVFSLQHVPNKVSARPSGSPTTSDLYDPDAWILSHLEVLHSPEVEKMPQAPPAILAVSSGINRSINITDPGYLVSSMIQKWTVATVEQELHPLFADLPSKGSGNTGSRSVITLQGNTEKNEQLITTIHQVDGHQALIVTTQENRTDFLSSEDLSSVSYAASATETSSMAQSGFTFPFTPDLMCPGFSPNACVRADIGQDDKTQITAMENQFGQIDPEQTLDPNVDAAVAALNLAFARACWSNATIDDVLMCALQTIPSELAPMVVSSMYRTLFRDTEFINEKTQGSELERIFHKQVMGRVMAYHASLTAYCRQLPSISSTDGREGWSLSAQWAWVANNIRYTATLLFMNLRDLQNANVQVSQDFSDMLCSNIRWGLGVIRFMISAILEVGDRETNPEMFGDKGHGRLGDTAGDGTQGLIALLLNIHCSRIFLVAFIRAVRAYAKNTEPRTRHQLQMLQCIQQQTTGKGITFQAIEAMFEYRWAAQGDVEGDVAATTARQLEMMATGVVFESYQPTIKILLTKLFNSPAGLRAKMLVDRLKLFTDQVDVENVFLNHDVLGAHADDKKRKPVIYDVHRKKPILKGVLEPGGTGEPVIRRCIRCGSFSADIVVPPPDWSKTVSQLLSKCICDGQWVIEPWKKYADAD
Length933
PositionTail
OrganismExophiala sideris
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.08
Grand average of hydropathy-0.199
Instability index41.57
Isoelectric point5.82
Molecular weight103323.97
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02550
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     260.24|      81|     575|      91|     228|       1
---------------------------------------------------------------------------
   69-  116 (61.59/39.05)	AWSRH.GHIATISND...G..........................................................................snvhiecIRYdGTSHSYKLHDRLTLPTLFEDAV
  119-  175 (80.94/112.95)	AWSAHGGELAIIDGK...GRIFIYHTSLVAINSlTLARSGSLDQVSDTSQPIGVAWLNQD..................................................................
  569-  692 (117.71/64.55)	NEKTQGSELERIFHKqvmGRVMAYHASLTAYCR.QLPSISSTDGREGWSLSAQWAWVANNirytatllfmnlrdlqnanvqvsqdfsdmlcsnirwglgvIRF.MISAILEVGDRETNPEMFGDKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.75|      11|      26|     879|     890|       2
---------------------------------------------------------------------------
  879-  890 (17.60/15.32)	TGEPVIRRCIrC
  907-  917 (20.15/11.87)	TVSQLLSKCI.C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.88|      18|      30|     753|     770|       3
---------------------------------------------------------------------------
  753-  770 (31.86/21.90)	TTGKGITFQAIEAMFE.YR
  784-  802 (27.02/17.50)	TTARQLEMMATGVVFEsYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.24|      26|      41|     298|     323|       4
---------------------------------------------------------------------------
  298-  323 (47.15/33.73)	PNKVSARPSGSPTTSDLYDPDAWILS
  340-  365 (44.09/31.00)	PPAILAVSSGINRSINITDPGYLVSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.93|      42|     498|       6|      47|       8
---------------------------------------------------------------------------
    6-   47 (72.05/50.88)	ADLDQSDQFASEAFFNQNSLQQQIQQLDP.INNLGASANVTPA
  483-  525 (66.88/46.67)	ADIGQDDKTQITAMENQFGQIDPEQTLDPnVDAAVAALNLAFA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02550 with Med16 domain of Kingdom Fungi
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