<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02539

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDVEDQYMKDLFGEAEHVPSITTSAPAAKGLAQRLDALASSNCCSKIAWSRFGCIASVAEDARHINLRVLMRNPKSGEWTLPKPTEIWPSMPDSHEIVHLAYSAMGNDLAVVDSGGRIMLYTTGLTLGSMIPVHVALNDSSDEMNTIVGMHWLPVFLHNSKVFSFFFRSASRNSDTWTAKIQQYHTPGPHNPLEGKSALVCLTRKGTLRLLWQARNNQWSETTVELEDASLATSCSFTHASFSPENDGLLLIAHQLCRATRLYQLRINWNMPPKQENDSQNLTALPNPVLDVRSLLEEHFMSPQNLPNHSQDDTLATTNGNNVDSMYEFHLAKLLFVPPAPDQGTKEPTLQTILAVFTIVPPSHEGMMVDPSQRWGLASTIISRWEVQRDVGDNLSTCFDQLSVKKKAAAGVPLKHGTRLKRLDDVVVSPAVLMITPVRNNTMFALTLSDGSVQFRYRNTMDVVLPDESPDEVQSLTQSGFSFHHIDPCLHTAFSPSACVLATLTAEGQVKLEKMQYTNSSLNDIDENDSKHDAIAAIIALQYSSACMQYKVTDDILAILPANLGTSLTRMIVALCMRFLNVEFDVISGDYQQQILPLFRNHLSFRCFSLQNALGAADKTGPRKLSARLAWITLNLRHVSQSIFFHLRSDQALKYDSAISFVGLFKWYLDLCCYLLQELNSLHYAIKHEAHLGRPGREKDRDWIQEQIQKRHSPAMILLLSSMPRVFLRMTFRPLRHGYMHASNGFRSSTAMEQKNAFHKLLNTFHNSPVNQQSFGALEDFINEIDISIKNAYKTASLSVQDRSAIEKDMLLTLRIPPVLMPTVTAILTVSLDGLMSKVDPGKVHIHDISWLGLTDDHRTKKFNESRTIDVIRKVPLVSTVKLRVCPRCGSVMEDLAHGVGHHQPWVLQSHKICVCLSSWANPDGN
Length926
PositionTail
OrganismVerruconis gallopava
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Venturiales> Sympoventuriaceae> Verruconis.
Aromaticity0.07
Grand average of hydropathy-0.178
Instability index46.97
Isoelectric point6.78
Molecular weight103677.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02539
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.62|      28|      28|     273|     300|       1
---------------------------------------------------------------------------
  273-  300 (48.45/32.02)	PKQ.ENDSQNLTALPNPVLDVRSLLEEHF
  303-  331 (47.17/30.96)	PQNlPNHSQDDTLATTNGNNVDSMYEFHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.98|      11|      28|     547|     557|       2
---------------------------------------------------------------------------
  547-  557 (21.05/14.61)	CMQY.KVTDDIL
  576-  587 (16.93/10.39)	CMRFlNVEFDVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.30|      36|      71|     612|     649|       3
---------------------------------------------------------------------------
  612-  649 (55.37/47.75)	NALGAADK....TG.PRKLSARlAWI..TLNLRHvSQSIFFHLRS
  680-  722 (50.92/34.24)	NSLHYAIKheahLGrPGREKDR.DWIqeQIQKRH.SPAMILLLSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.18|      23|     273|      74|      96|       4
---------------------------------------------------------------------------
   74-   96 (47.45/28.04)	PKSG..EWTLPKPTEIWPSMPDSHE
  341-  365 (37.72/20.88)	PDQGtkEPTLQTILAVFTIVPPSHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.04|      21|      63|     591|     611|       6
---------------------------------------------------------------------------
  591-  611 (40.52/29.98)	YQQQI..LPLFRNHLSFRCFSLQ
  655-  677 (36.52/26.24)	YDSAIsfVGLFKWYLDLCCYLLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.68|      11|      16|     744|     758|       7
---------------------------------------------------------------------------
  744-  754 (19.64/21.09)	NGFRSSTAMEQ
  763-  773 (21.04/ 8.49)	NTFHNSPVNQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.22|      14|      16|     822|     835|      12
---------------------------------------------------------------------------
  822-  835 (22.93/12.86)	PTVTAILTVSLDGL
  841-  854 (27.28/16.57)	PGKVHIHDISWLGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02539 with Med16 domain of Kingdom Fungi
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