<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02538

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMFSPPRPSAIPPSPTSPPKSGLKRRRPSDIDSIPQTPISPPFMSVATKSYVSAYGNSHNTDDVSGRSSPQSPALSGPRAVSSSHNNPRSATSIPTPANSVTGIPGLEMIEDNDQHRDKRARLDHDGDEDMSRMEIDSTTQPTNHDRQDSRDMDGQQGQNSGFTDGRSQTAMQQQKDLGEPFLLRRSKIRAQGPDPQQHLLAMYGLGPLLRSVARTDPKTGEKINKLRKSYEGQVKMFGLAGKTRTIKGERNVDEDQPGPLRRMVGSTAWGLETDEQWNATHGSSKIEVTADFKSKLKQAAQIQPGLCANNQWWENELGLADRPRIPPTVQQPPVSALGPSRIPNGVQRPLPGQAGEAKRSTRGKKRSYSDDSFVGYGEGYSEGEDAGTGDEYGGTRKRRKDIVGHTPVTYGQYAGR
Length416
PositionHead
OrganismExophiala mesophila (Black yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.05
Grand average of hydropathy-1.024
Instability index58.34
Isoelectric point9.38
Molecular weight45432.75
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02538
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.54|      14|      15|     323|     336|       1
---------------------------------------------------------------------------
    7-   21 (26.26/ 9.04)	PSaIPPSPTSPPKSG
  323-  336 (29.27/10.83)	PR.IPPTVQQPPVSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.23|      23|      25|      53|      77|       2
---------------------------------------------------------------------------
   53-   77 (36.10/28.91)	AYGNSHNTDDvSGRSSPqSPA..LSG.P
   79-  104 (33.13/17.57)	AVSSSHNNPR.SATSIP.TPAnsVTGiP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.00|      14|      15|     148|     161|       3
---------------------------------------------------------------------------
  148-  161 (26.75/15.07)	DSRDMDG.QQGQNSG
  164-  178 (18.25/ 7.87)	DGRSQTAmQQQKDLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.09|      25|      25|     180|     204|       5
---------------------------------------------------------------------------
  180-  204 (46.96/24.87)	PFLLRRS.KIRAQGPDPQ.....QHL.......LAMYG
  207-  238 (20.83/ 7.40)	PLL..RS.VART...DPKtgekiNKLrksyegqVKMFG
  257-  282 (41.29/21.08)	PGPLRRMvGSTAWGLETD.....EQW.......NATHG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02538 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELGLADRPRIPPTVQQPPVSALGPSRIPNGVQRPLPGQAGEAKRSTRGKKRSYSDDSFVGYGEGYSEGEDAGTGDEYGGTRKRRKDIVGHTPVTYGQYAGR
2) FGLAGKTRTIKGERNVDEDQPGPLRRMVGSTAWGLETDEQWNATHGSSK
3) MFSPPRPSAIPPSPTSPPKSGLKRRRPSDIDSIPQTPISPPFMSVATKSYVSAYGNSHNTDDVSGRSSPQSPALSGPRAVSSSHNNPRSATSIPTPANSVTGIPGLEMIEDNDQHRDKRARLDHDGDEDMSRMEIDSTTQPTNHDRQDSRDMDGQQGQNSGFTDGRSQTAMQQQKDLGEPFLLRRSKIRAQGPDPQQHLLAMYGLGPLLRSVARTDPKTGEKINKLR
316
237
1
416
285
227










Molecular Recognition Features






MoRF SequenceStartStop




1) GQYAG
2) PFLLRRSKIR
3) YGEGYSE
4) YGGTRKRRKDIV
411
180
376
392
415
189
382
403