<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02536

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSHNVLPQSSLDFLKSCSTGVHLIAGFSSINYWVYAVDETLSDQTTIAKQKSLEETLLDAEIKARDQKRIVYRDGTLQTLWFFAGRSEPPFNETPDPDGDSSYIELHGWVFRIMFSGVFKASELGIYSVRLAAQHSALPTQIPTEALASASLAKGAAQARHIQEHATPSNSSPVTSFPYDKNDIRSLHAFFIRAVQSFFAYTLAKELRALQLDLGTFVSFHDDSKSREEEDGAPRALPVFTLDTSLANGGGLLLSTTLKEDISLSPYLECSSEVGQGCSVIVVPGGLHATVVPDYTSSETTDVRLWKAYVAYQLRARGIDLGEINPQDRWILLKTQIPMGQNEKDPGQETNFYWPMTLCFSLFHPCSDSTESFITPQAWGSAESYWFLQTVPNDRDGYQDPLRFAQDWYDGRLARDKIITERNSLKEMTRKQAENGNLPVTSPSYIRDALQVTAGVYPTPPDGVLSSQAQTIQDVPAVSLPVDPNGHRSSLDMQHGEMMDLDMGPFEENARQRMSVISRTSLDISMKTGGDDLFGDDMVDDDLRGQDITDADFSFFDEPELPDTLAVDEGDQSINGAQVKSFENAEIVNPQGENPESFFEAQESPSQVLCSREAADKRDARSADEVTVTEMDDTTSFNAERKSGHEPLSPLLLQKKLFNFSTHHQPERRASQFQPLAFNTIIGQNDAKYTLDGAFGFKTRILGIANNHFATSPRIKPRPPDIRGKGLSGLTRRSITSPSQLRSRSSDCSSDVTDSSDDDSFYGDDMRCYISSPLKGKILEGTSSVDDDNDARSASTANGLARDRFNIGFDYKLVFSSIVQGNTDLEKFQTFKTLSCSQGQSGKLGASITDSCFSSALPREDPLNPLHKDFINVAQIVAEQIALGFVNETRTSRHSIMACDENAGLSFIKPIAKLKEAMAAIRQCCNAASPCDLLRWLCVQEIPPERQAVPKGNPPIPQKKLTISGLQTSDGSPVPATALAPLAPPHVRVRRNDDLWDMLPPALPFWEQLGLAPAAGKKNVLAFCVCPGNPDLTKQVSLFMDYLGATFESCKLGAHVRATQIGNIADGVVPVSLSADASEHSIFQSVRETCIEFGKTIANFDWSCKINFSPPIEDLNKIDTLVIYMIDPFTNSSRGLAELCSSFWTLYETYRQAVASPMRRTVRPDIVLQVLPIRYVANPHTPVVMDSLFYQKLAREIYDRCPPALPDTSASPLPIESAAAVLLEQSLPRKIDFKLQAEPPPDLLHEGSNLHLAYARSKNREWISVAWTDGTGKYQATSSYCLVGGRSFAEVARVIWQSTIEIMQARRVAWRLCIARVGILEREELDIWSMLATSPSPVVMITVIMTVDPNPPISVFHEHPSLSSKLGNQGSSNTPVGTPLSGVSPDIVLTPAATPNTEAGVDLSNDPDAHLVDIYDETWGLILGHRTNVSSSVADYRPSLSSGYLMKGSAASVVPTHDPEEAESQDIILIGIKLVWIGSSPKPNPTTQNQQSQPSPVSLQASYNGMSSNFPTEQAAATGYSSQSTPPTAASTPGQSSQLSTSTSGSSIPKVTADSILRDYLQMYRNLGVLAKARGLHGSMRGALPWHVLVASRAVEGLEASYGTLKINS
Length1609
PositionKinase
OrganismVerruconis gallopava
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Venturiales> Sympoventuriaceae> Verruconis.
Aromaticity0.08
Grand average of hydropathy-0.300
Instability index46.94
Isoelectric point5.11
Molecular weight176164.92
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02536
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.41|      23|     272|     230|     261|       1
---------------------------------------------------------------------------
  231-  257 (35.29/23.17)	DGAPRALPvftlDTS.....LANGGGLLLSTT
 1199- 1226 (36.12/13.54)	DRCPPALP....DTSasplpIESAAAVLLEQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.68|      43|     272|     666|     708|       2
---------------------------------------------------------------------------
  666-  708 (76.60/49.95)	PERRASQF.....QPLAFNTIIGQN....DAKYTLDGAFGFKTRILGIANNH
  944-  986 (61.88/38.62)	PERQAV........PKG.NPPIPQKkltiSGLQTSDGSPVPATALAPLAPPH
  988- 1021 (34.20/17.33)	RVRRNDDLwdmlpPALPFWEQLG...........LAPAAG.KKNVL......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.55|      19|     170|     604|     623|       3
---------------------------------------------------------------------------
  604-  623 (30.81/21.53)	SPSQvLCSREAADKRDARSA
  737-  755 (32.74/18.51)	SPSQ.LRSRSSDCSSDVTDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.73|      31|     312|    1025|    1070|       4
---------------------------------------------------------------------------
  818-  848 (53.83/19.25)	IVQGNTDLEK.FQTFKTLSCSQGQSGKLGASI
 1025- 1056 (52.90/42.83)	VCPGNPDLTKqVSLFMDYLGATFESCKLGAHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.72|      25|     243|     524|     557|       6
---------------------------------------------------------------------------
  492-  518 (39.95/31.30)	DMQHGEMMDLDM.GpfEENARQRMSVIS
  532-  557 (39.77/23.09)	DLFGDDMVDDDLrG..QDITDADFSFFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.77|      39|     133|    1349|    1404|       8
---------------------------------------------------------------------------
 1354- 1392 (69.10/34.75)	SVFHEHPSLSSKLGNQGS..SNTPVGTPLS..GVSPDIVLTPA
 1432- 1469 (49.80/25.93)	SVADYRPSLSSGYLMKGSaaSVVPTHDPEE..AESQDIIL...
 1481- 1515 (43.88/14.36)	......PKPNPTTQNQQS..QPSPVSLQASynGMSSNFPTEQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.22|      16|     746|     351|     368|      16
---------------------------------------------------------------------------
  351-  368 (32.19/26.61)	NFYWPMTLCFSlfHPCSD
 1099- 1114 (34.03/20.83)	NFDWSCKINFS..PPIED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.52|      20|     106|     192|     215|      19
---------------------------------------------------------------------------
  192-  215 (29.51/28.37)	IRAVQSFFAYtlakELRALQLDLG
  303-  322 (37.01/24.56)	VRLWKAYVAY....QLRARGIDLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02536 with Med13 domain of Kingdom Fungi
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