<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02527

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWNQSFTSAPAVSIGGGSGNATSGVAHPSGSFASHARSNSLAASPSAHRRVSGIAQGQLASSPSANPPFSRPFANTAFPGTVVAPRSTAASNTASAPTRSLQRLPLLTSQTPTSIAKLAFPAHTTVFWHRLHKNNARLAPQLDPDYQRVDASTSTAASSANTSQGSQNAWNTAVQHIITTCKQSRIQPPVTEEPQHHLTPFQLLLKDVLFYTSSRHSSPTGDTHTHLIAPVSHADLWLFVVVTDQEEIKASTSASSAGASDTNATGAAAANQEGTSPLHPTLVRRLPANLVKSLQRLSECAITSSGSYPLPVAAPNCIDLKGKRSSLTQDQRQAHRRFMASVKAKLVDALAASQSTSTNPTQSHAMPRRARLRLGRGVVFLPPRPSDSSSIALSDAAWFAAPKQSISFDGRVESDCLMTRFTTLLTTTSLFVYAHSRRFGALPLTDSRYATFLPSLPSSSASPTMLIAPLGYHVELLGIVPTSSVAEEHLSELYSRLATLSAGPIDDTRDISSLFASGLAICALPRSIQRLHDQQPRLPDPLPNEPDIASSQAEATDEVMTPPVAAQGHEQARKGSSQFGPESRHFLWPAAWCLVVPDQSRTLARAAAPDDLQNLQSQPMTPLKELVSFTLKVLNDANESSPVQNASAYTPGEPDDASLAQHRVDLIPSTRPDITPASISFPDFDFAMPTVASATSSQALPPAGHSVAATSPLKREPTNTEPMPGASTTEAFAQDLNWMQFLPSQINEAPASASASALADQSNLTSSSAPGAVDASTQGPGGTQNPQLDQSGTNWLLSTGSASAPLEGGADAATATAAAAPAQAPNLGVPPSLLQPHSAMHSHGATPLQQMDNTPLALTQPTSTKRKAGEGDIFDNLGLLTDDDFSFFDESAFGLHPEAGLPPHHVNQPAEAAQLAPSHDLDYDQRLMSEGNGPGVKATSSAIVDPQPATSSASIVDDVAMDDAGQSSLDALFSAIPGLQHAMASADLSQAQSTAPQATALSAAPMQPAQLRTGASTAPETAAATAGSMHAFHPAMNSFTPRDASVATPFGDPASLPGFTPSSLTESSPTFGNPQYKTPRTPYSPIEEYRDGATIVDLQNDRRMRESAQASRERNATSAPHLYASSQHPVLKRGAEDQLRLADVSTAAAAAAAHAAMDMDLSNRKRPAIVPNAFLPLPQTETRKPLQRLAIGARANLGRKYDLLGKFASRPKPATITNSASNANNVPLPERRLSGDASRAGGRADKEGAAESAQFDKQSLTSHSRPRATRRLPSRTPSGRGLALLQLHRDRQTKASPGSVLTALRHPSSSRTLEAPATPRSSDDLARSGAVSASESDASSSDGNDDSDDARSDTEATALTLSPADQATLKASSLEVISTYLCGATSLSKPPWSPAVSGPIDEASDDVSLPRQSVQPPGLHLCTVPRDSYTDSSAIQRRPTMRRSTLSRTAEWLIQNPQFRSMYGFGMASITTGTDVAVGDKIEVLEAMASVLSIAPASEGSKQPSDTDMDSAAAGNEAQSALPTLKYLVKVTGRATGEVAAAACAADADSGLEIAEVLEPSRIAVGCQGSVVEALPSALTLWDKSKLSAVSGQKHVVAKVLLTDASPAWHEEIVAWLDRVRIAFETHGLGTHIGNAQSILAIADGSETLALSSYLEQLWQDGEAWLDTLRSISNRVQLDLLQGKHVVVYTLQPPNSTICASAGFHGLLRLEADLRAMLSEQVGVLAEQLLVRAVSPSMMTESGSLGFGQHSQALRTLAFSVYDQLPRLVRRQPAKVLHGKEPGPISALVQFPAFSLSSAFGRASSGTRLAGAAGRTQFSLSWPREPAGVTDEHVLLHVGYRICEAVRGGKAAEARRSDRLSSRNGSAASLAGASISELGHLADDDAPGPAMREKVVMVSAIDERGGSSTVDALAANDGDGSIEACVERVWRFALAEASRAHLHWRLVISSTGLMKQCELRAWQRLIDAYLSSSGAQERVIASVVLLSVRPDESGAVLAERGVGIKARQEWTAASTADKGSLMLLDAADLSQMVCFAEPMPMEWTQASGGWAAIGEEDEDAEQDGDEKEATAMPLASAILVHRTRPDLVGGGGRTSTSSETKHKHCPDGFTPYSHVLAVDMLQVWRLEAAQQTSVQNKEAKEAEEALRSGALDGIMRSLHRLRLISQERHQLPWPYNAQPWCVASVNTLAACLDGIVLRD
Length2199
PositionKinase
OrganismUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Ustilago.
Aromaticity0.05
Grand average of hydropathy-0.281
Instability index50.41
Isoelectric point5.92
Molecular weight232230.64
Publications
PubMed=17080091

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02527
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     266.34|      45|      46|     934|     978|       1
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  767-  817 (45.53/15.91)	SSAPGavdastQ.GPGGTQ....NP.QLDQS............GTnwllSTGS...AS..APLE..GGADAATATA
  897-  928 (40.87/13.44)	...........P.EAGLPPHHVNQP.AEAAQ............LA....P.SH...DL..DYDQ.........RLM
  929-  973 (68.33/28.00)	SEGNG......P.GVKATSSAIVDP.QPATS............SA....SIVD...DV..AMDD..AGQSSLDALF
  974- 1001 (32.15/ 8.82)	SAIPG....................lQHAMA............SA...........DL..SQAQ..STAPQATAL.
 1002- 1050 (50.92/18.77)	SAAPM......Q.PAQLRTGASTAP.ETAAA............TA....GSMH...AFhpAMNSftPRDASVATPF
 1054- 1111 (28.54/ 6.91)	ASLPG....ftPsSLTESSPTFGNP.QYKTPrtpyspieeyrdGA....TIVDlqnDR..RMRE..SAQAS.....
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.40|      12|      16|      41|      56|       2
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   41-   52 (21.94/17.54)	LAASPSAHRRVS
   59-   70 (23.46/ 6.84)	LASSPSANPPFS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     199.14|      48|      54|    1302|    1349|       3
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 1232- 1259 (25.21/ 6.03)	....................RLSGDAS.....RAGGRADKE...GAAESAQFDKQS..
 1261- 1296 (28.98/ 8.14)	TSHS.RPRATRRL..PSrTP.SGRGLAllqlhRDRQTKAS..................
 1302- 1349 (81.80/37.69)	TALR.HPSSSRTLEAPA.TPRSSDDLA.....RSGAVSASE...SDASSSDGNDDSDD
 1357- 1406 (63.14/27.25)	TALTlSPADQATLKASS.LEVISTYL.......CGATSLSKppwSPAVSGPIDEASDD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     202.04|      46|      46|    1664|    1709|       4
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 1615- 1660 (71.13/42.08)	AWLDRVRIAFETHGLGTHIGNAQSILAIADGSETLALSSYL..EQ.LWQ
 1664- 1709 (77.04/46.24)	AWLDTLRSISNRVQLDLLQGKHVVVYTLQPPNSTICASAGF..HG.LLR
 1712- 1755 (53.86/29.91)	A..D.LRAMLSE.QVGVL.AEQLLVRAVSPSMMTESGSLGFgqHSqALR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     340.27|      97|     664|     448|     562|       5
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   71-  161 (108.22/47.03)	........RPfANTAFPGT.....VVAPRSTAASNTASAPTRSLQRLPLltSQTPTSIAKL.AFPAH.....TTVF..WH............RLHKNNARLAPQL..DPDyqrvdastsTAASSAN
  376-  443 (81.20/33.10)	RGVVFLPPRP.SDSSSIALsdaawFAAP.KQSISFDGRVESDC..........LMTRFTTLLT........TTSLFvyAHSRRFGALP......................................
  448-  554 (150.85/100.43)	RYATFLPSLP.SSSASPTM.....LIAPLGYHVELLGIVPTSSVAEEHL..SELYSRLATLSAGPIDdtrdISSLF..ASGLAICALPrsiqRLHDQQPRLPDPLpnEPD.........IASSQAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.94|      40|      45|    1129|    1172|       6
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 1129- 1172 (57.13/41.20)	PVLKRGAEDQL.RLAdVStaaAAAAAHAAMDM..DLSNRKRPAIVPN
 1176- 1218 (59.80/32.06)	PLPQTETRKPLqRLA.IG...ARANLGRKYDLlgKFASRPKPATITN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.51|      29|      31|    1866|    1895|       7
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 1866- 1895 (46.01/31.25)	SAASLAGASiSELGHLADDDAPG..PAMREKV
 1899- 1929 (45.50/26.26)	SAIDERGGS.STVDALAANDGDGsiEACVERV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     469.77|     135|    1242|     182|     326|       8
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  182-  326 (210.90/124.73)	KQSRIQPPVteepQHHLTPFQLLLKDvlfyTSSRHSSPTGDTHTHLIAPVShADL.WLFVVVTDQEEIKASTSASSAGASDTNATGAAAANqEGTSPL..HP.TLVRRLPANLVKSLQRLS......ECAI.TSSGSYPLPVAAPNCIDLKGKRSS
  576-  665 (118.06/52.58)	...................................SSQFGPESRHFLWPAA.....W.CLVVPDQ....SRTLARAAAPDDLQ.............NLqsQPmTPLKELVSFTLKVLNDAN......ESSP.VQNASAYTP.GEPDDASLAQHRVD
  695-  756 (66.14/26.49)	TSSQALPPA....GHSVAATSPLKRE....PTNTEPMP.GASTTEAFA....QDLnWMQFLPSQINEAPASASAS.................................................................................
 1495- 1570 (74.67/29.33)	.....................................................................APASEGSKQPSDTDMDSAAAGN.EAQSAL...P.TL.....KYLVKVTGRATgevaaaACAAdADSGLEIAEVLEPSRIAV.GCQGS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.17|      22|     720|     855|     890|      11
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  830-  853 (38.07/14.05)	PPSLLQPHSAMHSHGATPLqqMDN
  855-  876 (39.10/44.48)	PLALTQPTSTKRKAGEGDI..FDN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.82|      24|      31|    1930|    1954|      13
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 1930- 1954 (40.06/28.15)	W.RFALAEASRAHLHWRlVISSTGLM
 1962- 1986 (35.76/20.13)	WqRLIDAYLSSSGAQER.VIASVVLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02527 with Med13 domain of Kingdom Fungi
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