<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02514

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSLAEVTRNCFQCGVAPSKWISLCKLFISKLPPIDSPETVASHLSNSVLVLYRSYPGNPGLKEYLECAIEDGILPLFTFVSTFLQAARSPELDTPITLDHLCQIALEVQKRSDSQVANSLVPYSESQIVILGTIQDGLALLRTVHTLPISQHHNELASRTEELVRHLLCFASDISQVSVAQACVSFADVNDLLNNFRFNLETRQMLESFSMLLGLLIGDDAKVAREAQMMQSLQLALGKGDTGGPASDTDVITLGLVHHYLVVILCIDILLRSQVSKISHRAHEFGAGNTLGVVTLLVYIFRWSSWTPTVFYTQLILSALIGLTQHPTDCTIWKAFIVGRLPNLISAFEAIVSADHAMVSDWRGGFRSGLISVFQRPDIIIQCDHTLSEGGGSNMITEENMPSSFTRELLQQFVKLELIDKVLGAQLDPSISKENMSKLSSDTHDTSMDFSLYLESRLTPDMARNDAQSWLDRIWRDAGTHTTFANFVLKKFSSLVTAVDVESLSQLCKLLYTHAIALDIVALHVKISDLLFHALLFLDSYDCETIGDPQTAVSHLGDVVLFVQYTLARFQFDTTTFTKDGRSISTAFLKSAFTVYPVENLPPNELLSFNGWFKAIFDSSSEGIEDTILRSTQPKILLRISATLFSQAIKAASTQKIDKDVLFNGVSYFTGPLLNWTLVGVIKALSQEILLKGLSAPIHIEILQTLVLSSSCPQPVLALCSPQILRLLSELGKDGAKTSMIDVDQVTLSEIQTITAEPFLDDPKSRVQIWQQDPQKALQNVFLQARSHKTPVLDVERCLRMIPVTKFLQMMWMDLFESAKLGEMESCKRIATFVLTMPRCSNVPPLLPIFIHLVLPSLIAAADRQQPQDQNISVELFVAVISCVLSAALHLEWAMVTVYGNDRVPLGQASSAVARRLAADLGSKRRSPTSQNIVQRLVASQSFTANFPMFIAEL
Length954
PositionTail
OrganismLaccaria amethystina LaAM-08-1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Tricholomataceae> Laccaria.
Aromaticity0.08
Grand average of hydropathy0.199
Instability index45.52
Isoelectric point5.62
Molecular weight105579.79
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02514
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.16|      32|      34|     396|     427|       1
---------------------------------------------------------------------------
  366-  391 (25.07/13.12)	...........FRSGLISVFQRPDIIiqcDHTLSEGG
  396-  427 (52.98/36.44)	ITEENMP..SSFTRELLQQFVKLELI...DKVLGAQL
  431-  450 (17.12/ 6.48)	ISKENMSklSSDTHDTSMDF.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     265.69|      84|     293|     186|     274|       2
---------------------------------------------------------------------------
   69-  151 (98.01/59.21)	...IEDgILPLFTFvstflqaarspELDTPITLDHL...............CQIALEVQKRSDSQVA....NSLVPYSESQIVILGTIQDGLALLRTVHTLPISQ
  186-  274 (131.73/95.56)	FAdVND.LLNNFRF...........NLETRQMLESFSMLLGLL....IGDDAKVAREAQMMQSLQLAlgkgDTGGPASDTDVITLGLVHHYLVVILCIDILLRSQ
  484-  526 (35.95/16.09)	FA..NF.VLKKFS............SLVTAVDVESLSQLCKLLythaIALDI.VALHVK..............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.39|      30|      40|     790|     819|       3
---------------------------------------------------------------------------
  790-  819 (55.43/34.64)	TPVLDVERCLRMIPVTK.FLQMMWMDLFESA
  832-  862 (48.96/29.75)	TFVLTMPRCSNVPPLLPiFIHLVLPSLIAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.16|      27|     509|      26|      52|       8
---------------------------------------------------------------------------
   26-   52 (47.76/29.00)	LFISKL..PPIDSPETVASHLSNSVL.VLY
  536-  565 (39.39/22.71)	LFLDSYdcETIGDPQTAVSHLGDVVLfVQY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02514 with Med5 domain of Kingdom Fungi
Unable to open file!