<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02495

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTDASLTNTIILSGIANIRYKCYVQSYTKSSLMSFLTCEGFHGNPSYIDLPESHNAIIDAYNHMLTLNIPATWHILSNQKTDKETAMLELWVFWFDYRHTQVIETDPRLKELKESKSGSFDWNQITSKNGQSPTSSPQLNQHTKSESITLVPGTEYKLFIKSIRHLIQRAMIHKRHAFALGEFFVFPETYQDDGNVMQDKMANHDILSVKNTMLACMYNVYFTTSNLVFQPSTRRMRLRSLSPADFYSKHLKVLLCPTGEHARILSFHSLPADLQFKALNQWAEFYDMPVSLLTQNKDCMPSLITIRTASQDTVVYPSALVFVPTDTKESPAAVAGMNGIMGLNHGLTEDLGAKASRMAYYQRLKFNNTQAKDTDIDYWSYKDPMIHVGNAVFEALSSVDVKYQQDQLLLHRALIEPIVGSPIMNAKSVVPTNYDSPFFMSGLHRKSITPPTASSAQQEHSMQLTEYVISRFDDTSIDDPMLDLLQDPNVVSATSNDGLSIGGGSHLSALLKKALIIDSTDHPPLPANDNSTEQQPSAPLQIPPSLAHPQTDTLPVKDDSQVLQPPLEDFDLMYDQQGTTLHNTNAWDADDGFGDLDLDVTDADFDFFETPVVVAPPLPPPVPATEPNVLQILPMDIDSPKTDTVKVPLQPEPIDQEMVDVQVSVMKPIPDNNDSLFTPFVVSHDSTENTSTAAATADDASYTVTPKIQETSTPQKRATYQKSTPELSSFVPRDFLPVPVKASVNDAKYSAGGKFMYDPSKEQTIADNTGFTVSKRSLLYSPDYIPTKPKKRLSKSKQQELNETKANPSLKTQTKSSWINKENDESSSDSDSSSSSDRSGSDDSSSGNGSFTTDDSQSSDTESESDIDKMDDSTVNEDMIERRSKALKRFQKSVVYSQLKATPAPVPTDRLQFLDYDTPFAPVLAHGSIKPIKWRHSKAMEESLAYLCEQAVLGGYPLAGGLAEVSENGGEIEGEPAKVLVARRNNLMQMTRGVVTHVPSLQADVCSMANEFRSILQDIFIETAADENGDMDLLSTTTPDTLEPVSYPNSPLMGKIGIRGPLNTQEYYNLNESHNQGHSKYGKYQIKKRRPDEPNLDIIKQPDIVVSRHEDNLEGSSAMISFWEKLGLDPYSAKKQIKYLVVYPNNTDIENSVQHFFKGLGNVYEACHLGRHEPQYAGPFTNGLVPVSVADLDNNESSVRQRLKSYEETCEAVGRHLAMDEVQQKQQHYTQNYYTVIYIVNPGPHMSSYLDMCRCFYKLIEAYSRVTHQNFADQQPRIALQLMPIDHILGSSAFGGYTMLGMKDIAFSVYSKCFARVTRKITKPTQRSWTDIYAPAFILTKPLQRTIKFKLNDIRPFPTIMEQNAVLHMAYCFSYDRAWMSVVWVDDRGELLQYDLYSRKTAFKEAWQRTLEIAKRTAFRWTIVITKLGLMFNDELLYWLRYVSTSIEHQVTIVAMDVESGLHLHFNACYPNRDKVTSQLQDSQQPSFLDAQGKTHVAVAGGMNYGREQQGKHHQSNSTTCTAVSEAQILLLNHRISYSQKRERAYKGILRPEANTEEENWMIPLATGYLIHHSLPNKNVNPCMEQFNNEAFVAEVCASI
Length1601
PositionKinase
OrganismMucor ambiguus
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.09
Grand average of hydropathy-0.454
Instability index49.75
Isoelectric point5.54
Molecular weight179849.62
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02495
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.83|      15|      26|     526|     551|       1
---------------------------------------------------------------------------
  526-  542 (24.02/30.62)	LPANDNSTEQQPsaPLQ
  555-  569 (27.81/ 7.48)	LPVKDDSQVLQP..PLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.57|      63|      93|    1311|    1374|       2
---------------------------------------------------------------------------
 1311- 1374 (108.65/75.95)	YSKCFARvTRKITKPTQRSWTDIYAP.AFILTKPLQRTIKFKLNDIRPFPTI..MEQNAVLHMAY..CF
 1404- 1471 (97.92/63.82)	FKEAWQR.TLEIAKRTAFRWTIVITKlGLMFNDELLYWLRYVSTSIEHQVTIvaMDVESGLHLHFnaCY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     199.26|      59|      93|     751|     809|       3
---------------------------------------------------------------------------
  751-  808 (95.05/54.77)	......................................SAGGKFMYDPSKEQTIADNTGFTVSKRSLLYSPDYIPT......KP.K..KRLSKS.KQQELNETKAN
  809-  906 (66.19/35.85)	PslktqtksswinkendesssdsdsssssdrsgsddssSGNGSFTTDDSQSSDTESESDIDKMDDSTV.NEDMIER......RS.KalKRFQKSvVYSQLKATPAP
  908-  945 (38.01/17.38)	P...................................................T..DRLQF......LDYDTPFAPVlahgsiKPiK..WRHSKA.MEESL......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.52|      16|      21|     344|     362|       5
---------------------------------------------------------------------------
  344-  362 (22.84/26.31)	LNHGLTEdlgAKASRMAYY
  365-  380 (29.68/22.04)	LKFNNTQ...AKDTDIDYW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.80|      23|      95|     602|     651|       9
---------------------------------------------------------------------------
  416-  438 (41.63/11.33)	IEPIVGSPI....MNAKSVVPTNYDSP
  615-  641 (38.17/31.87)	VAPPLPPPVpatePNVLQILPMDIDSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.32|      13|      94|     486|     499|      10
---------------------------------------------------------------------------
  486-  498 (23.73/11.26)	LQDPNVVSATSND
  677-  689 (23.59/ 7.00)	LFTPFVVSHDSTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.24|       9|      94|     312|     321|      11
---------------------------------------------------------------------------
  296-  304 (18.22/10.97)	QNKDCMPS.L
  312-  321 (12.01/10.65)	QDTVVYPSaL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.32|      15|      15|     814|     828|      12
---------------------------------------------------------------------------
  814-  828 (26.50/17.12)	QTKSSWINKENDESS
  832-  846 (24.82/15.51)	DSSSSSDRSGSDDSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.49|      22|     432|     590|     613|      13
---------------------------------------------------------------------------
  590-  613 (32.53/29.32)	ADDGFGDLDLdVTDADFDFFEtPV
 1025- 1046 (39.96/25.10)	AADENGDMDL.LSTTTPDTLE.PV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02495 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RSLLYSPDYIPTKPKKRLSKSKQQELNETKANPSLKTQTKSSWINKENDESSSDSDSSSSSDRSGSDDSSSGNGSFTTDDSQSSDTESESDIDKMDDSTVNEDMIERR
2) STDHPPLPANDNSTEQQPSAPLQIPPSLAHPQTDTLPVKDDSQVLQPPLEDFDLMYDQQGTTLHNTNAWDADDGFGD
3) TENTSTAAATADDASYTVTPKIQETSTPQKRATYQKSTPE
777
520
688
884
596
727










Molecular Recognition Features






MoRF SequenceStartStop




1) KRSLLYSPDYIPTKPKKRLSKSK
776
798