<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02492

Description "Isocitrate dehydrogenase [NAD] subunit, mitochondrial"
SequenceMLSSKFISKPNVVAIQKIATRSFASATSIPVPAPVEQKSIFPKKYGGTYTVTLIPGDGIGQELAGAVKDVFKAANVPVDFEQYDVSGLTSEDDSLFQQSIESLRRNKVGIKGTLFTPTSKLGHKSFNVSMRKDLDMYASLSLCKNVPGVESRLSNVDIAIIRENTEGEYSGLEHQSVPGVVESLKIITRAKTERIARFAFDFAVKNNRKKVTIIHKANIMKLADGLFLRTCRDVAKEYAHHDIEVNDMIVDNTAMQLVSRPQQFDVMVMPNLYGNIVSNVGAGLIGGPGLIPGCNIGREYAMFEPGCRHVALDIQNQNSANPTAMLLSSVMMLRHLNLDEHANRISSAVYETINSGKARTVDIGGTSTTKEFTNAVISSFTSQTGPKPVLVQIEDQYNKRIDDDIGKLVDCFTDIVKVGENKDKDKFKVAQEGYQIESQSAQIVRSCESLLSLIGELKQNLLLNDTKTLTTLRQTRSERLIENTAAIKDRMQLMKKELAETVYDLETVFYRPLTDA
Length516
PositionHead
OrganismMucor ambiguus
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.06
Grand average of hydropathy-0.229
Instability index37.13
Isoelectric point7.59
Molecular weight56998.60
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
mitochondrion	GO:0005739	IEA:UniProtKB-SubCell

GO - Biological Function
isocitrate dehydrogenase (NAD+) activity	GO:0004449	IEA:UniProtKB-UniRule
magnesium ion binding	GO:0000287	IEA:UniProtKB-UniRule
NAD binding	GO:0051287	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
tricarboxylic acid cycle	GO:0006099	IEA:UniProtKB-UniRule









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02492
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.58|      22|      75|     213|     235|       1
---------------------------------------------------------------------------
  213-  235 (34.87/29.27)	IIHKANIMKlADGLFLRTCRDVA
  290-  311 (43.70/31.85)	LIPGCNIGR.EYAMFEPGCRHVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.70|      13|      24|     249|     261|       2
---------------------------------------------------------------------------
  249-  261 (22.85/15.17)	IVDNTAMQLVSRP
  276-  288 (22.86/15.18)	IVSNVGAGLIGGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.75|      29|      29|     137|     165|       3
---------------------------------------------------------------------------
  102-  134 (21.39/11.27)	....SLRRNKVGIKgtlftptSKLGHKSFNVsMRKDL
  137-  165 (48.22/34.24)	YASLSLCKNVPGVE.......SRLSNVDIAI.IRENT
  169-  192 (38.14/25.61)	YSGLE.HQSVPGVV.......ESLK....II.TRAKT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02492 with Med22 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA