<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02492

Description "Isocitrate dehydrogenase [NAD] subunit, mitochondrial"
SequenceMLSSKFISKPNVVAIQKIATRSFASATSIPVPAPVEQKSIFPKKYGGTYTVTLIPGDGIGQELAGAVKDVFKAANVPVDFEQYDVSGLTSEDDSLFQQSIESLRRNKVGIKGTLFTPTSKLGHKSFNVSMRKDLDMYASLSLCKNVPGVESRLSNVDIAIIRENTEGEYSGLEHQSVPGVVESLKIITRAKTERIARFAFDFAVKNNRKKVTIIHKANIMKLADGLFLRTCRDVAKEYAHHDIEVNDMIVDNTAMQLVSRPQQFDVMVMPNLYGNIVSNVGAGLIGGPGLIPGCNIGREYAMFEPGCRHVALDIQNQNSANPTAMLLSSVMMLRHLNLDEHANRISSAVYETINSGKARTVDIGGTSTTKEFTNAVISSFTSQTGPKPVLVQIEDQYNKRIDDDIGKLVDCFTDIVKVGENKDKDKFKVAQEGYQIESQSAQIVRSCESLLSLIGELKQNLLLNDTKTLTTLRQTRSERLIENTAAIKDRMQLMKKELAETVYDLETVFYRPLTDA
Length516
PositionHead
OrganismMucor ambiguus
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.06
Grand average of hydropathy-0.229
Instability index37.13
Isoelectric point7.59
Molecular weight56998.60
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
mitochondrion	GO:0005739	IEA:UniProtKB-SubCell

GO - Biological Function
isocitrate dehydrogenase (NAD+) activity	GO:0004449	IEA:UniProtKB-UniRule
magnesium ion binding	GO:0000287	IEA:UniProtKB-UniRule
NAD binding	GO:0051287	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
tricarboxylic acid cycle	GO:0006099	IEA:UniProtKB-UniRule









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02492
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.58|      22|      75|     213|     235|       1
---------------------------------------------------------------------------
  213-  235 (34.87/29.27)	IIHKANIMKlADGLFLRTCRDVA
  290-  311 (43.70/31.85)	LIPGCNIGR.EYAMFEPGCRHVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.70|      13|      24|     249|     261|       2
---------------------------------------------------------------------------
  249-  261 (22.85/15.17)	IVDNTAMQLVSRP
  276-  288 (22.86/15.18)	IVSNVGAGLIGGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.75|      29|      29|     137|     165|       3
---------------------------------------------------------------------------
  102-  134 (21.39/11.27)	....SLRRNKVGIKgtlftptSKLGHKSFNVsMRKDL
  137-  165 (48.22/34.24)	YASLSLCKNVPGVE.......SRLSNVDIAI.IRENT
  169-  192 (38.14/25.61)	YSGLE.HQSVPGVV.......ESLK....II.TRAKT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02492 with Med22 domain of Kingdom Fungi
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