<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02476

Description 50S rRNA methyltransferase
SequenceMHRPFSIRGFASVRNFKTPSSPTSVQKKTNLIGLTLDDLKQELAGLNHSKNYSALQIWQHMYKKGYTQFEDMPNISKDLQQELNHKYEIKYGEVKLDKIALDKTRKFLIGFNTKQDPRAIVETVIIPETNRSTLCVSSQVGCSLKCSFCHTGTQKLERSLTSGEVVGQYMIAATHSGDFPFKDDKKKMISNMVFMGQGEPLYNWKNVSKGIRILTDPQGLNWSKPKITVSTSGVVPLIPKIATELGVSLAISLHATNNTLRDVLVPLNKTFPLETVLEACRTYAFHMGNRGRRITFEYVMLDHVNDSLSDARAMVKLLKQLPAHVNLIPFNPWPGSGYESTKMEHIESFSQPQPAAQQTSSLFGGLSNNTTTLASGGLFGGGGAAPTSTATSAPLTSSTTANTTSNLFSSTPSTTQQTPSLFGSTAPKPTTSFFGASANAANNTTTSNLLNPAFPMNSQQQQQQQQQQQQQQQQQQTQLLDIKNCFPDTNIPHFIVSQDSITRSTVPANTFFGSKSRDTITSSSQNTNMSITSFALNERNTILPGFLTASDTSNMSTGTSNSSKIKLPNKKRVLEQEDEDNDGRNVISKTSNQGVFSQSSKLTEGFNLTLKKQSDRDVLPLNTYGDTRLNVAGNDYRIKNFNAENMTQKQHLTNSYISTIVPESKAHNRRVRVFGFNPQQAEKIINHFTNLGDLAEPCTRQGNWITFHYVNHESALRAILDNGKKIGEDYLVGVAWDESANEVERTQLDNPPDLYKRHSNSAYSIFKEPAQPKPQQQPALSNQHLSADNTLWNKLREKFLGW
Length802
PositionTail
OrganismMucor ambiguus
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.08
Grand average of hydropathy-0.576
Instability index42.37
Isoelectric point9.21
Molecular weight89059.97
Publications









Function






Annotated function


GO - Cellular Component
nuclear pore	GO:0005643	IEA:UniProtKB-UniRule

GO - Biological Function
iron-sulfur cluster binding	GO:0051536	IEA:UniProtKB-KW
metal ion binding	GO:0046872	IEA:UniProtKB-KW
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process
mRNA transport	GO:0051028	IEA:UniProtKB-UniRule
rRNA base methylation	GO:0070475	IEA:InterPro
tRNA methylation	GO:0030488	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02476
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      57.09|      12|      39|     397|     408|       1
---------------------------------------------------------------------------
  380-  391 (16.56/ 7.52)	GGGGAAPTSTAT
  397-  408 (21.22/12.24)	SSTTANTTSNLF
  423-  434 (19.31/10.31)	GSTAPKPTTSFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.56|      33|      35|     622|     654|       2
---------------------------------------------------------------------------
  581-  604 (20.71/ 9.36)	............NDGRnviSKTSNQGVFSQSS....KLTE
  622-  654 (59.56/41.84)	NTYGDTRLNVAGNDYR...IKNFNAENMTQKQ....HLTN
  664-  690 (36.29/22.38)	SKAHNRRVRVFG..........FNPQ...QAEkiinHFTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.67|       8|      37|      38|      48|       3
---------------------------------------------------------------------------
   38-   48 (11.09/12.51)	DLKQELaglNH
   78-   85 (16.58/ 8.23)	DLQQEL...NH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     101.28|      35|     110|     110|     148|       4
---------------------------------------------------------------------------
  110-  131 (29.47/16.39)	...................................................................................GFNTKQDPRAIVETV.IIPETNR
  136-  148 (10.90/ 8.39)	VSSQVGCSLKCSF.............................................................................................
  219-  240 (21.55/ 9.29)	.............chtgtqklersltsgevvgqymiaathsgdfpfkddkkkmisnmvfmgqgeplynwknvskgiriltdpqGLNWSK.PKITVSTSgVVPLIPK
  241-  281 (39.36/21.67)	IATELGVSLAISL..........................................................hatnntlrdvlvPLN.KTFP...LETV.L..EACR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02476 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASGGLFGGGGAAPTSTATSAPLTSSTTANTTSNLFSSTPSTTQQTPSLFGSTAPKPTTSFFGASANAAN
2) GFLTASDTSNMSTGTSNSSKIKLPNKKRVLEQEDEDNDGRNVISKTSNQG
3) TTTSNLLNPAFPMNSQQQQQQQQQQQQQQQQQQTQLLDIK
4) VPANTFFGSKSRDTITSSSQNTNMSITSFA
374
545
444
506
442
594
483
535










Molecular Recognition Features






MoRF SequenceStartStop




NANANA