<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02475

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMQPVLSPKDEIESTKTNGYIKHEEINGKPLNAVQETTTTMTSNNDNEEKVVLPVEMASMVPLKALIGKLIHKAHADLITLTETLPSMSEVEKKRQILTYTTFVRKQFLKLLVLVKWAENANDMQMCQNIMAFLANQNQIFTSTVDFLHKIYTELPAARLRNFDIPTAVDVLTTGTYQRMPTKIKDMLTPTPLTDEEVLETFQNMNDVIRMRMVTTEVLPSPMRKYRIGKYLFLDNEFEVALTLMGHSNDRRWWIVSLDVFIQATSVGGASEDVDISLNDNQKQHLRVNAQKQLVPPNPDEPTKLFFPLVNMYDYLHLCCLNMQLEILYIQAAMLSKTRWMNQLKVQMNQDRTKLTVVYWRGGSPASHWARPQAHSKGIKSTVLEISVSHPDQQPQPENVAVAVRDELKGLVQKAGIGASIALSDLSANEQARVLSSLKYPKNCLDVLWDDNANLHTERKLLDSANLNLEQLVLHVTNYHGKCIIDKFRELLNSQKDFLEENGLHLAEEENREGSQLTLVDGNVATKKLTDAPCLLTIEILEPSDSTPSLVVRYRHQKYISIECDARTGRVKASETGDGCSEGDFKLRGLEDKLNNDPQDIARHLLWLRSEVVVREVIALAKQLNLQPYHPSQMNLRPEDLQKLFGDVLSDATTSATTSTTAIASTGNSKYPSHCMFLQFSQFEDWYFIIATVKNEFKAWLCCINKTYDQNGLYQAIVDLAHFDCNQVWKDQFAEKLPTASKNIEDAYTSTTNTNTHKRKIEAGEEDAPSITHEGIKRRRMSMRRDESEAVSLTKIDNLSIDLRFLAKLDSLCRAYITNRMIELQLQSFKGSLKYHMRPLLQSLSSMETQVMNHPAADKMEVVCVSQRDLLKTCAYHFAEDGSKREKPIETIPWIERLLPSLKNDVLIRSFGWWDCGRGDCYVVVQEKFDWKHLQLQGNDLGDHISLDKSTNVLSFTYPNIDTCIDNFLMDWERIFMMANLTRQMSSSWFEKYNEQLSFNATNLQELSFSYAKDFTCTIQWSSSSKGHPRQYSIKLGTTDDINKAKPAALPTLNSRNPHWRIASFLRDVLNDKKDLIYFVQILFQTLPLMACLERLEVECAQKGDIGKVSIIPRAYDSVRVIFSAMHAIDIRFTDKATICVSDAAYHHLYYSSRTASVDTFVAPQPYLVQAPLPSQQATEASSEGIKPIKVAQQFRFTPIDQFADLLKSMETWIFSFEPKDVDRWYVSGELWDQKTEPSAVSLQHGLLCSASLCQGILNKLQEVL
Length1264
PositionTail
OrganismMucor ambiguus
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.08
Grand average of hydropathy-0.339
Instability index42.22
Isoelectric point6.02
Molecular weight144087.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02475
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.67|      22|      22|     158|     179|       1
---------------------------------------------------------------------------
  158-  179 (37.85/23.69)	RLRNFDIPTAV.DVLTTGTYQRM
  182-  204 (32.82/19.57)	KIKDMLTPTPLtDEEVLETFQNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.01|      47|     330|      62|     121|       2
---------------------------------------------------------------------------
   62-  121 (58.04/74.33)	LKALIGKlihkahaDLITLTETLPSMSEVEKKRqILTYTTFvRKQFLKLLvlvkWAENAN
  407-  453 (79.97/56.92)	LKGLVQK.......AGIGASIALSDLSANEQAR.VLSSLKY.PKNCLDVL....WDDNAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.03|      20|     327|     212|     231|       3
---------------------------------------------------------------------------
  212-  231 (37.67/29.35)	MVTTEVL......PSPMRKYRIGKYL
  534-  559 (29.35/21.07)	LLTIEILepsdstPSLVVRYRHQKYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     209.20|      69|     327|     800|     871|       4
---------------------------------------------------------------------------
  800-  871 (110.06/98.83)	IDLRFLAKlDSLC.......RAYITNRMIElqLQSFKGSLKYHMRPLLQSLSSMETQVMN.HP..AADKMEVVCVSQ.RDLLK
 1128- 1207 (99.13/77.11)	IDIRFTDK.ATICvsdaayhHLYYSSRTAS..VDTFVAPQPYLVQAPLPSQQATEASSEGiKPikVAQQFRFTPIDQfADLLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.10|      58|     659|     252|     405|       5
---------------------------------------------------------------------------
  340-  405 (84.69/183.61)	MNQLKVQMNQDRTklTVVYWrGGSPASHwarPQAHSkgIK.STVLEISVSHPDQQP.....QPE.NVAVAVRD
 1003- 1067 (89.40/25.35)	LQELSFSYAKDFT..CTIQW.SSSSKGH...PRQYS..IKlGTTDDINKAKPAALPtlnsrNPHwRIASFLRD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02475 with Med14 domain of Kingdom Fungi
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