Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MPSLDLSKLHDDLATTEQEVGSIIESFIELGVSIYDFPGTSEAAQGMMTNLQRNVDRLRNLNRKSNDPDSQLAGFQVPMEVLQYIEDGRNPDVYTRDFVEAIRRSNQYQRAKMNGVKQLRDKLAEKIVAEFPDMQDSVKDILQRTDR |
Length | 147 |
Position | Middle |
Organism | Lachancea lanzarotensis |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.688 |
Instability index | 49.81 |
Isoelectric point | 4.84 |
Molecular weight | 16837.71 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi RNA polymerase II preinitiation complex assembly GO:0051123 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP02469 No repeats found |
MoRF Sequence | Start | Stop |
1) ILQRTDR 2) LRNLNR 3) QLAGFQVPMEVLQYIEDGRNPDVYTRDFVEAIRR | 141 58 71 | 147 63 104 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab