<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02467

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEHTELPYRLEELLTSLYRLETVEQINYVQYIPCKADAQWSIQAELALRKQNSKVLTSLFSRELWCFSINNDPIPSLELKHLGTAPTPEKSGHFTPDYSKPNLPTAYAVFLKALRRMIHINLCAESKQHMVPFGNSCLLKSNKATVSNKIVHFEPQLFDNGDLCVSVCSKEMRLHPLDISNVTESYLKTHAIYLAPSGIRAYLASSDIKNCISPAPRNASVLLITLLVSHGIDLTKKTDLTWVRISPNLDHLNGYTPCIASYLDVPKITKTAIWPLELCFAQSCLNPLSLQQKPTFQPDLQHTFDLIDDFIQLKLTSAFKTPGSTSGGPGSGIITANNALSTGGMYPDQYPTFHKHTQSGSLAALGIFNNPATSRQSPNMSLTNVTPVNSRSAPQSVENMSFGFLTTPNVNENIDAMNDDIDMSDSPRKLTTGQWDKEVRANDKNFGMPGASNDDKSTSSISRSEEDADLEVELFGDLNDDDNEDDNQKTNSPPTGIDAGHHIKEITDEMFDLADDSDQSKEKTANLKDPSPFNIGESPFKRKYLDIPLDEITLPTTPLYTDPGAPLPVETPKDRKKSVFAPLNFNPIIESNVDNKYKNGGKFSLDGSKVEESLKFDVSTANISSSEDDDSGSEIEEYGDLINAAPPAAEEHRAIINFPVETQPPTTMEISQSDVFKDSAVLQRSENDTGDGQDILSSSSDTWKYPKSGAFENFSPQRSHLSLGGTKMGQFTSAYDTDDLLKLTTVTPFSEKSSKSPATNYLTDISADGSEHKENGEALYNESPAAPETPNSLPFLLRHMPLFSMPSVFFHRNPVLPMRENINPLLDLLTDQIVFDSGLLNGINSGPTAYSKFKDCSDGAIKRTMKNVFSKFERLNGGEIVEEINYIPQPAVHLKKADEVIKMKADVELFSPHLRLRPYRGPKNFKALFLTTDLKDDCLDFLSTMSQTYSSEELGFCELVKLTFADTPGLIYLINFEKDTLLLLSAQIVSYCSTNTINKMPVPLLILLPLSGKSMADVVTMTRKFDFLAKEVTSKLPNVNILLKIIPMDFLKNPLVSVDEYYNLCVGIYNSVPPKNTKFSAIAEEIPKKIEFRVGQQSNGQISHFDVYIHLAYARSIDRNWMCAAWSNSSGSESGVKTWYIGNSNSAFEEACSQMWQTTSKMVAKNYSKVCLILSRFDSVLPDDELMHWRRLSSTTRNLHLAVVCVGDDTKLSLYDEDRLYPSFKPILENEKLSQTIDTTNLDNYEIVDIRNEVHGILFQNPLQLANSQHRCGIRTGALVRFKASSGHNVLDKFEVNLLNCPHLDSTKLLKIILQEFRNLASLNTWFGISETEYSFVPWHVVAVKKMLNAVVHLRVPEAI
Length1360
PositionKinase
OrganismLachancea lanzarotensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.08
Grand average of hydropathy-0.347
Instability index43.01
Isoelectric point5.30
Molecular weight151662.89
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02467
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     174.66|      43|      65|     674|     716|       1
---------------------------------------------------------------------------
  610-  646 (48.82/26.81)	..VEESLKFDVSTANI.SSSED.DDS.GSEIEEY...G.DLINAAP
  674-  716 (72.44/43.51)	DVFKDSAVLQRSENDT.GDGQDILSS.SSDTWKYPKSG.AFENFSP
  739-  784 (53.40/30.04)	DLLKLTTVTPFSEKSSkSPATNYLTDiSADGSEHKENGeALYNESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.05|      23|     430|     842|     873|       2
---------------------------------------------------------------------------
  842-  873 (29.34/44.05)	GINSGptAYSKFKdCSDGaikrtmKNVFSKFE
 1273- 1295 (42.71/28.01)	GIRTG..ALVRFK.ASSG......HNVLDKFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.78|      48|     111|     266|     313|       3
---------------------------------------------------------------------------
  265-  312 (81.57/47.70)	V........PKITKTAIWPLE.LCFAQSCLNPLSL..QQKPTFQPDLQH.TFDLIDDFIQ
  313-  368 (43.37/21.74)	LkltsafktPGSTSGG..PGSgIITANNALSTGGMypDQYPTFHKHTQSgSLAALGIF..
  378-  422 (65.84/37.01)	.........PNMSLTNVTPVN.SRSAPQSVENMSF..GFLTT..PNVNE.NIDAMNDDID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.80|      31|      31|     512|     542|       6
---------------------------------------------------------------------------
  477-  506 (49.54/26.28)	DLNDDDNEDDNQKTN..SPP.TGIDAGHHIKEI
  512-  542 (52.42/28.26)	DLADDSDQSKEKTANL.KDP.SPFNIGESPFKR
  546-  575 (38.84/18.93)	DIP..LDEITLPTTPLyTDPgAPLPV.ETPKDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.98|      48|      58|      54|     103|       7
---------------------------------------------------------------------------
   54-  103 (77.00/61.37)	KVLTSLFSRELwCFSINNDPIP...SLELKHlGTAPTPEKSGHFTPD.YSKPNL
  112-  163 (74.98/49.08)	KALRRMIHINL.CAESKQHMVPfgnSCLLKS.NKATVSNKIVHFEPQlFDNGDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02467 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HRAIINFPVETQPPTTMEISQSDVFKDSAVLQRSENDTGDGQDILSSS
2) TSRQSPNMSLTNVTPVNSRSAPQSVENMSFGFLTTPNVNENIDAMNDDIDMSDSPRKLTTGQWDKEVRANDKNFGMPGASNDDKSTSSISRSEEDADLEVELFGDLNDDDNEDDNQKTNSPPTGIDAGHHIKEITDEMFDLADDSDQSKEKTANLKDPSPFNI
652
373
699
535










Molecular Recognition Features






MoRF SequenceStartStop




1) GHHIKEITDEMFDL
2) IEEYGDLI
3) RKYLDIPLDEIT
500
635
542
513
642
553