<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02465

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTNNPPDQSSQAANHETKRIPLAIDPNFMKTTSSALPTDQSDDNDKSQNGTHQNATTGQSLVNNPYEMFGSMPLDQLIPVILQSRGIGSKFADLSERVLSEEIANDAEDMEHVKNLDEDVEMDSSDFPANADQEALKPQQIEGPLAREEEDQMTQEQFQQLKNSTVQSLNLSVNEASLALEFVSLLLSSVRPSAANASMSPFLKNAVPTASLNAEKIPYEKATESEIVDKKLTTRGWKLRSLEESRVLLKDTHKTLEASLRKEQNYWSKVSANTSKKDVIFKMKDQETGEKSLGLKYGYEDSGSSYKQERGIAILRYNANKDALEAVPAEKQQFESMNRGPFEKFMRVRIFTKIQEEDDYILSGETALDDLLLAADNSGAEQNIRRQISKLQFLIFEKELMYHLKKESETLISYGVTLENENKITVEFPTEKIEFEMMNLTDEVILNHQQDAPKTNDRKAALILVMLRMLLVVMYKKQIRKKLLMVAHSKAVHPFDNEALLLRPIMGKFRHENYLNLLQKVIKTYVLDVVANSVVTEIPSDYRKQNIPVRRETYDKHITKLDDEITLFDKILQLPRIDLKVELPGSGKIEFGLESSNYCNATTSVKLVDASNATIFDTRFSNFKELEDFLHFIVSEYVTEGKQE
Length644
PositionHead
OrganismLachancea lanzarotensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.07
Grand average of hydropathy-0.546
Instability index44.86
Isoelectric point5.15
Molecular weight73190.98
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
activating transcription factor binding	GO:0033613	IEA:EnsemblFungi
RNA polymerase II complex recruiting activity	GO:0001139	IEA:EnsemblFungi
RNA polymerase II core promoter sequence-specific DNA binding	GO:0000979	IEA:EnsemblFungi
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02465
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.06|      12|     153|     426|     437|       1
---------------------------------------------------------------------------
  426-  437 (23.21/14.62)	VEFP.TEKIEFEM
  581-  593 (17.85/ 9.67)	VELPgSGKIEFGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.36|      41|     185|     130|     187|       2
---------------------------------------------------------------------------
  130-  141 (-2.01/10.44)	.................................NADQEALKpQQI
  156-  187 (33.09/15.33)	EQFQQLKNST.VQSLNLSVNEASLALEfvSLLL............
  343-  384 (62.27/25.42)	EKFMRVRIFTkIQEEDDYILSGETALD..DLLLAADNSGAE.QNI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02465 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTNNPPDQSSQAANHETKRIPLAIDPNFMKTTSSALPTDQSDDNDKSQNGTHQNATTGQSLVNNPYEMF
2) VLSEEIANDAEDMEHVKNLDEDVEMDSSDFPANADQEALKPQQIEGPLAREEEDQMTQEQFQQL
1
98
69
161










Molecular Recognition Features






MoRF SequenceStartStop




1) AANHETKRIPLAIDPNFMKTTS
12
33