Description | Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MVLQLCLTSAIDDDSYELCTSTLCNLSGNPPVLFNNFTAMFKPNPSFDIEQTNSKNQLIEQNRLKLCKGVPLDCLEPDNKQRDHRMLRKYDDDELKGFDLRILQRMLHGSIDVDEMDVDERDASDSAWILSISDIPPAGANRKVSSQAITESTITTTGGSSASITSFLSELGYILDYRLLVIGVKFNMKHNVYLELSKIWQIDNAGITRQLTKGGFMVKAFVNVAKSTDIKSINNGTNALLNLQKELSGYIDLTIPDRKSMDSRLENLNDI |
Length | 271 |
Position | Head |
Organism | Lachancea lanzarotensis |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.297 |
Instability index | 30.04 |
Isoelectric point | 4.99 |
Molecular weight | 30334.16 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA:EnsemblFungi transcription coactivator activity GO:0003713 IEA:EnsemblFungi |
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi RNA polymerase II preinitiation complex assembly GO:0051123 IEA:EnsemblFungi termination of RNA polymerase II transcription GO:0006369 IEA:EnsemblFungi transcription open complex formation at RNA polymerase II promoter GO:0001113 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP02459 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 90.52| 29| 134| 103| 135| 1 --------------------------------------------------------------------------- 103- 135 (40.22/38.65) LQRMLHGSIDvdeMDVDERDASDSAwILSISDI 243- 271 (50.31/32.17) LQKELSGYID...LTIPDRKSMDSR.LENLNDI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) RLENL 2) YIDLTI | 264 250 | 268 255 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab