<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02436

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDPGDYDTNSLLIDDVASISFRVYEPVLSSSTYTFAASDVERALRRDGHLVYADAVRRVLWSFSLLGRDASQVAPLDLAQTLEICGYKLNKVTDGIFEPTSLLKTRPSTTNAMNTPSSSCSTGSALDQPARSNQPAQSGSSSAWTSGATDYEIKHDLRGYSSVPVKEVYEYFISAVLSSLSAAFCAKIGAIALNPRSLLLPRAASPLDDGTVGPNQPRPILATLRVYLTTTGSLVIGLALSAMNGIMSCAEHVVTNPIPPRIPVLVAPLGAYGTLQNSFDASSGFDQHSVQSPDTQITRSRPDTDERIARWRIDCIKILEMRGVSPSVLSGTSWVSIQFLRKRASEHKIDGKRTPGGATAGTGTMYWPSVLCFHRASRSDRQSYLSSESLGVAETAAMDPLSSARAWLVGAEERDALLLRRTKEREALASRVAADGDARAQSSNGYSPLKLRRQSNSNAAPLPGTMYPTPPDGVQNPAAATSYLEGTVSSPANAPGAALIAPAADVDVIMTQPGAGTTEGFADGWEGADVKRAETEFLGDMGADIFGDNDITDADFSFFDEQPGGGDMDFSGMSGMGAALETPASGSLPFGTYPQRPVEPAAPPQTIPLPPVFAKPELKHARSSLVDVARFGHDDTRLRKQPSGGIKRQPSPFDPDTVFKRVRASLESTSAASNRNPHPTRRGSVFEKVDFDPYLALNNKKYQENGRFGYRWDVKKENRANDATSPPTTDYLRRHGKGRSKLKELPSNVGALLAKITGDLETSSLQQSPAKMDDPPSDADDVSLVSDQDDTSYTSEEPTSPTRSVATRRRPEDDAISMATSLRDLDPAGASSPQVSVDLSRFANSESPELPLARWFAEPEPAGLPGSYGDDDFIMIAQILTEQAASGMLKLAATPHADSEFSNPRETRRNISACARYSLQVLRSALPRSLSGALECRFKLLLDVEDVPLVEPPNQLPTGPTGSPERTHPNLFQIPPPQFELRRHETRLSLLPSSIDFWESLGLGPSQGPKDVLAVCVFPEWEGLLDHVDNFLNRTRNVYDSLKLGAFERLPTVGGLSNGLVPYEVGINSPIESPSSVVARPGSVVADRMSKLSQALAATVASEKNFVVYYVYTPSNPTSIVDCCAAFQRLFELYKKMLSDKRAQSNNELVMQLLPLDMVASASSLAIPEPSEYARLCLETYDRCTLFDGTMPAPAIILEQPLPRLIEFKLTSTPSTNVLHENSCIHIAYAQSVDERWMTAAWTDNRGIKQMTASYCLGRRDRPLSTPFAKVAQEIWETTEELISAWRVRWQVIVTKCGPMDQQEVDTWVGLQQGESKMPSISLTLLTVDTDPSLLLVPPPTTIPLTTTHTLYTTPASTPQASVMSPEQANGPATPMGTGPSSGPANPTTPGTEPNASEPGIDTTLVDIADETWGAILSHRLNNAASLTDLTPALVSGYLVKRGGTRLEDPPVAMELNVIYTEGNPRMYEALLREMLTYFRGLGSLARARGVVDRDVDVRPWHIAAAEKGVQVLHQLL
Length1517
PositionKinase
OrganismMagnaporthiopsis poae (strain ATCC 64411 / 73-15) (Kentucky bluegrass fungus) (Magnaporthe poae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Magnaporthaceae> Magnaporthiopsis.
Aromaticity0.07
Grand average of hydropathy-0.314
Instability index50.35
Isoelectric point5.22
Molecular weight164229.90
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02436
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1687.56|     376|     377|     462|     837|       1
---------------------------------------------------------------------------
    1-  380 (424.10/191.69)	..............MD..PGDYDTNSlLIDDVASISFRVYEPvlSSSTY.TFAAsdveRAL........RRDGHLVYADAV.RrvlwSFSLLGRDASQVApL............dlaqtleI..............CGYKLNKVTDGIFEP...TSLLKtrPSTTNAMNTPSSSCsTGSALDQPARSNQPAqSGSSSAWTSGA.TDYEIKhdlRGYSSVPV......KEVYEYFISAVLSSLSAAFCAKI...G.AIALNPRSLL....LPRAAS.PLDD...GTVgPNQP.RPILATL.RVYLT...TTgslvigLALSAM.NG.IMSCA....EHVVT.NPIPPRIpvLVAPLGAYG.........TLQNS.FDA.SSGFDQHSVQSPDTQ.ITRSR.P..DTDERIARW.RIDCI.KILEM..RGVSPSVLSGTSWVSIQFLRKR..ASEHKIDGKRTPGGATAGTGTMywPS.VLCF..HRASRSD
  385-  759 (565.14/258.05)	LSSESLGVAETA..AMDPLSSARAWL.VGAEERDALLLRR....TKERE.ALAS....RVA........ADGDA..RAQSS.N....GYSP...............................lklrrqsnsnaaplPGTMYPTPPDGVQNPAAATSYLE..GTVSSPANAPGAAL.IAPAADVDVIMTQPG.AGTTEGFADGW.EGADVK...RAETEFLG......DMGADIFGDNDITDADFSFFDEQPGGG.DMDFSGMSGM.GAALETPASGSLPF...GTY.PQRPVEPAAPPQ.TIPLP...PV......FAKPEL.KH.ARSSL....VDVARFGHDDTRL..RKQPSGGIK.........RQPSP.FDP.DTVFKRVRASLESTS.AASNRNP..HPTRRGSVFEKVDFD.PYLALNNKKYQENGRFGYRWDVKKENRANDATSPPTTDYLRRHGKGRSKLKEL..PSNVGAL..LAKITGD
  760- 1136 (453.24/205.40)	LETSSLQQSPAK..MDDPPSDADDVS.LVSDQDDTSYTSEEP..TSPTR.SVAT....RRR........PEDDAISMATSL.R....DLDPAGASSPQVS.V...............dlsrF..............ANSESPELP.......LARWF....AE.PEPAGLPGS......YGDDDFIMI..A.QILTEQAASGMlKLAATP...HADSEFSNpretrrNISACARYSLQVLR...SALPRSLSGAlECRFKLLLDVeDVPLVEPPN.QLPT...G...PTGSPERTHPNLfQIP.P...PQ......F...ELrRHeTRLSLlpssID...FWES...L..GLGPSQGPKdvlavcvfpEWEGL.LDHvDNFLNRTRNVYDSLKlGAFERLPtvGGLSNGLVPYEVGINsPIESPSSVVARPGSVVADR..MSKLSQALAATVASEKNFVVYYVYTPSNPTSI..VDCCAAFqrLFELYKK
 1137- 1395 (245.07/107.45)	MLSDKRAQSNNElvMQLLP..LDMVA.SAS.....SLAIPEP..SEYARlCLET....YDRctlfdgtmPA.PAIILEQPLpR....LIEFKLTSTPSTN.VlhenscihiayaqsvderwM................TAAWTDNRGIKQMTA..SYCL..GRRDRPLSTPFAKV.AQEI......................W.ETTEEL...ISAWRVRW......QVIVTKCGPMDQQEVD.TWVGLQQGES.KM................PSISLTLltvDTD.PSLLLVP..PPT.TIPLTtthTL......YTTPA..ST.PQASV....MSPEQANGPATPM..GTGPSSGPA.........NPTTPgTEP.N...............................................................................................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02436 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARFGHDDTRLRKQPSGGIKRQPSPFDPDTVFKRVRASLESTSAASNRNPHPTRRGSVFEK
2) GALLAKITGDLETSSLQQSPAKMDDPPSDADDVSLVSDQDDTSYTSEEPTSPTRSVATRRRPEDDAISMATSLRDLDPAGASSPQVSVDLSRFA
3) LTTTHTLYTTPASTPQASVMSPEQANGPATPMGTGPSSGPANPTTPGTEPNASEPGIDTT
4) PSTTNAMNTPSSSCSTGSALDQPARSNQPAQSGSS
5) RFGYRWDVKKENRANDATSPPTTDYLRRHGKGRSKLKELPSN
6) SNAAPLPGTMYPTPPDGVQNPAAATSYLEGT
7) TDADFSFFDEQPGGGDMDFSGMSGMGAALETPASGSLPFGTYPQRPVEPAAPPQTIPLPPVFA
629
750
1345
107
707
457
552
688
843
1404
141
748
487
614










Molecular Recognition Features






MoRF SequenceStartStop




1) DFSFF
555
559