<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02431

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDATMGAGMAVDLEEVEVDLFGDPVAVSLMSAPRPPPSKQLLSRLDEMRGRGCCQKIAWSRQGTIASVSADGRSVDLRYLRSHPDDAAWGLSDPTPYSSFGIVPPQAGGGQIAHLAWASSGIPELAVVDDVGRVSFIHCPVSLNRPFTTRAWDADPVDELGAIVGCFWLPLAPPGKQQYTALQGPAVREGNGWRYETSYKPVIGPSHPNPSKSAFVCITAGGMLKMFYSQPNNKVQEALLELENIGSSDDLVTHASICPDKSSSGLCIALALSSRLLKVVKVTINWGLPPQMDKQNLANTQPLNPTFKEKRVAVVSWMSLAGPTPEPEPPLDISMAHISLLELLPTTLASNNQQGFVPPLILAVRSHVSPFSHVMQSVLDAWEIVGDQAQSAQPQALHPAFQQLSSRAGTPATQPATRLRRWDPIWLDKVVVSIQLLHQGRVVCLAFSDGTVQHRDRYTLEVMYASPDLERISALDGLGFRFADETPCLQVAFSPTSCSFVQICEDSRVRWNSLRYPAADIGSTTQDAQYHAVVAGLALTVAAAASSQTNHDDILAIGRQFIDKPRFAYDWVMEVARMLKIHIDYSEEAHHDQLVRNHHLQLCLSILHHMGLYGEFNPRSFGGKFGAVALGVRSIVILITIASHTYKADKLVPLDEPDVVDALATGSKWTLDVLSWLAESLFDLADDPKFEALLNPTDWKNVVEYLHSRNNDVALHLLLCSSTRGFIQAACRRLVHLDSLSHRATDYYEKNYTQVPGQDNSAIPSNRLHLSYQRMQRYTSSSLIKVAEFGELLSALGSDIRTAYETMLRPLAERQRQQQQRQQQQQQQQQQGNKTQQQQQQQGGLDQAVKRAQAQCELTILLGNAPPPAFIPVLKKFFEVDLPAFRAQTDRAQLFFADFALLDVLDDPRSLQERRARGKHIDAFKRSEIELVPRDDGREPPATGRHQQLPGANGSTGALLRRRCVRCAAVMEDVTAQKPAVTFVIAQQRKCPCGGCWGLLAKGATVG
Length1007
PositionTail
OrganismMagnaporthiopsis poae (strain ATCC 64411 / 73-15) (Kentucky bluegrass fungus) (Magnaporthe poae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Magnaporthaceae> Magnaporthiopsis.
Aromaticity0.07
Grand average of hydropathy-0.219
Instability index45.81
Isoelectric point6.48
Molecular weight110902.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02431
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.80|      33|      33|     100|     132|       1
---------------------------------------------------------------------------
   63-   96 (38.02/20.74)	.GTIASVSADGRSVDLRYLRSH.PDDAawgLSDPTP
  100-  132 (56.90/35.01)	FGIVPPQAGGGQIAHLAWASSGIPELA...VVDDVG
  136-  165 (50.88/30.46)	F.IHCPVSLNRPFTTRAWDADPVDELG...AI..VG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.91|      38|     218|     170|     286|       3
---------------------------------------------------------------------------
  241-  285 (55.72/134.47)	ELENIGSSDDL.VTHASICPdksssglCIALALSSRLLKVVKV....TIN
  468-  510 (56.19/ 7.99)	DLERISALDGLgFRFADETP.......CLQVAFSPTSCSFVQIcedsRVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.60|      21|     116|     168|     210|       4
---------------------------------------------------------------------------
  168-  188 (40.48/20.67)	WLP..LAPPGKQQYTALQGPAVR
  343-  365 (32.12/14.80)	LLPttLASNNQQGFVPPLILAVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.75|      13|      23|     908|     920|       6
---------------------------------------------------------------------------
  908-  920 (24.49/13.93)	PR.SLQERRARGKH
  933-  946 (22.27/11.99)	PRdDGREPPATGRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.35|      50|      93|     286|     341|       7
---------------------------------------------------------------------------
  286-  341 (82.27/54.97)	WGLPPqmDKQNLANTQPLNPTFKEkrvaVVSWMSLAGPTPEP.....EPP.LDISMAHISLL
  382-  437 (76.08/38.66)	WEIVG..DQAQSAQPQALHPAFQQ....LSSRAGTPATQPATrlrrwDPIwLDKVVVSIQLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02431 with Med16 domain of Kingdom Fungi
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