<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02429

Description Uncharacterized protein
SequenceMTAKWAVLAFQCLLPAHTTLSQPHPPATAGLIWPWMHEGPRTSGSPTQANPVLAARLQIDLGQGCVVDSNRWMTLCSPLSPKSDAVAFSQEPAAQIVQYLKKPPPSSVCSTATPPNQTAWARPTVLPAPTKQLRKHEPGLSAIRCCISVVSRSELPLLPVASTTRIPSSRTHRVPCLSARSPTDAAVAILTRHPRLELCRRRLAEGYFDKAPSTPETSSAKALVFQSLKQTNRLQGLSIVYTEVLKHRRALGLVGSLSSFKPPPRVTLTDTKREVWLKDLANPAITLRRLSRTIPHGIRGRVLLDQCLNKKVPIERAVWLAKCVGANEIRAVRRKGTGQGTPALGMGGEAKWNRDWTVCVEQFVEGTITAIRSEDWKWRVDYAMRLARHLSFAELLDKDHYSEWLVSGLENSHLTKLPLWMILTQIHWRDILRLRKYGRRLVGAILNHLSNIQGHADNDLLQPVVGQLRWSVCRLLALGPESFVCPGTWLKHRSLIQESLPPGDASLQVVFKSVDSRNEQLASNCVRSQPAARAVLVRLLDATLHSPIPKDLSIQCLAVTKDRTAVARILLEWCTSLQRPGLAKMYVAVGLLKSWAVVGLDVTDTILQFLSTTSISEAERKDLVFRLVTELARVDLFSTHRYVQWLIARGGLSKPSEVEMDGPCITRLLVELPDSTMNESLRGLRASMLRRASYPVKDQNLELDNAIEAMKHILGMQPGPGHYARRFAGPPMSLHSYTRRLAKTVCSVKLQVAFWLRTTFLEALKQQQLQQQQQHLKGAADLPSDAFFCSCRRILEACQDFTMLGDLLRALSVAPSADVLASCSDTLMLHYPVFNATGVLKPLFETLLARLSPIVAEEHGSGVRRLLASLAALAGRMPGRKDLAARLSRDLNRYDRTSEIDACSPVSDNNHEAELQEEGAIEKLLASGTSIDKPTLERLFEHLVGLLQQLGDKDEERLRYPIGLLVRLRVLDPKQFDYLMARWIRTQSRRPNRLNPLLVYPPMVSLGCLSLSLVLSTLYGEMLSVSAATKTPTQPAPPTIVNSPAGSTVNQEILQLVLRPLAERCHVQMSTDERYRFHTSQKSVIRTNPNELLTLIRMAATEYAASSTADKATLPLANDKLRVALRSALMELVLTDFNTVARYLAAKHGDAGVSRIVERDMEMILVPGIEEDRRLSFDQVLELCNELTLPFCQLKLMASLTAEGAATGTAGAGDPSQRLQSQLELFARAMDKAIDARNITWTGMLSCLNPEITQHLRHRAQARFLDLLPSPGSLSHASDADTADKVQMAESLVSVMDIIIRGGSTGKSPPLASFMIDKLTDMWEILATAARGRGPPDLEADPIEYDDETAAAMAAVCNAIRRHWLPQLLTFLTLHTTTLDPSKASVDVRARAVIVLSGIAIELGNGEAPGYDDTHPMPPPPSSSTEDEEEAAEEEDEELMIPTATTTPTTPTQLSDDLDDQQLLQLQLQPPPQPPQPPQAQQQPPPSQQFKWRPFAPRRWELLNEPTPNIGENDSSLSLSLFRAFKVQ
Length1528
PositionKinase
OrganismMagnaporthiopsis poae (strain ATCC 64411 / 73-15) (Kentucky bluegrass fungus) (Magnaporthe poae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Magnaporthaceae> Magnaporthiopsis.
Aromaticity0.05
Grand average of hydropathy-0.182
Instability index53.41
Isoelectric point8.64
Molecular weight169111.98
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02429
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     646.20|     151|     157|     576|     727|       1
---------------------------------------------------------------------------
  333-  455 (144.86/73.42)	..RRKG..TGQGTPALGMggeakwNRDWTVC.......VEQF................VegTITAIrSEdwKWRV.DYAMRLARHLSFAELLDKDHYS....EWLVS..GLEN.....SHLTKL......PLWMILTQIHWRDIL.R......LRKYGR.........RLVGAI..LNHLSNIQ...GH.....
  456-  557 (76.84/35.51)	....AD..NDLLQPVVGQ......LR.WSVCRL......LALgpesfvcpgtwlkhrsL..IQESL.PP..GDASlQVVFKSVD..SRNEQLA..........................SNCVRSQPAARAVLVRLLDATLHSPIpKDLSIQCL........................................
  576-  727 (241.08/130.64)	SLQRPG..LAKMYVAVGL......LKSWAVVGLdVTDTILQF................L..STTSI.SE..AERK.DLVFRLVTELARVDLFSTHRYV....QWLIARGGLSK.....PSEVEMDGPCITRLLVELPDSTMNESL.RGLRASMLRRASYPV..KDQNLELDNAIEAMKHILGMQPGPGHYARRF
  733-  887 (183.41/94.91)	SLHSYTrrLAKTVCSVKL.....qVAFW......LRTTFLEA................L..KQQQL.QQ..QQQH....LKGAADLPSDAFFCSCRRIleacQDFTMLGDLLRalsvaPS.ADVLASCSDTLMLHYPVFNATGVL.KPLFETLLARLS.PIvaEEHGSGVRRLLASLAALAGRMPGRKDLAARL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.16|      20|      63|    1402|    1422|       2
---------------------------------------------------------------------------
 1402- 1421 (41.14/20.27)	ELGNGEAPGYDDTH.........PMPP.PP
 1449- 1478 (26.02/ 6.64)	TTPTQLSDDLDDQQllqlqlqppPQPPqPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     538.15|     177|    1009|      46|     258|       3
---------------------------------------------------------------------------
   46-  234 (281.83/196.31)	PTQANPVLAARLQIDLgqGCVVDSNRWMTLCSPLSPKSDAVAFSQEPAAQIVqyLKKPPPSSVCSTATPPNQTAWA.RPTVLPAPTKQLRKHEPGLSAIRccisvVSRSE.LPLLPVASTTRIPSSRTHR..VPCLS..ARSPTDAAVA..ILTrhpRLELCRRRLAEGYFDKAPS...........TPETSSAKALVF.QSLKQTNRL
  991- 1187 (256.32/125.77)	PNRLNPLLVYPPMVSL..GCLSLSLVLSTLYGEMLSVSAATKTPTQPAPPTI..VNSPAGSTVNQEILQLVLRPLAeRCHVQMSTDERYRFHTSQKSVIR.....TNPNElLTLIRMAATEYAASSTADKatLPLANdkLRVALRSALMelVLT...DFNTVARYLAAKHGDAGVSriverdmemilVPGIEEDRRLSFdQVLELCNEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.47|      17|      17|     944|     960|       4
---------------------------------------------------------------------------
  944-  960 (29.97/21.03)	VGLLQQLGDKDEERLRY
  962-  978 (27.50/18.55)	IGLLVRLRVLDPKQFDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.07|      17|      17|    1258|    1274|       5
---------------------------------------------------------------------------
 1258- 1274 (29.40/17.55)	HRAQARFLDLLPSPGSL
 1276- 1292 (27.66/16.06)	HASDADTADKVQMAESL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02429 with Med12 domain of Kingdom Fungi
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