<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02414

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMFEMELPVVCDGQVHLGELLSRVAQATYAELVELAETLPNMSDAARKRTLADWVVKTKKQVVKLYAVMKWARDADTVQTCMNITAFLMNQNQQFLDVIDRLTYAKENLDPARLRNHDLLTSLDVLTSGTYKRLPSAIKKSFIPVPPLTDAEVIKTLNAMEDTIRYRLRMTEIIPIEMSQHRIAGGRVHFIVPKLFETSICLRGAEKDDGWFFVGVKFLFKVGGDTTGNREFPQEPTGILKRHIADEADARMACYLPFPETAEATSEVLSNIEKPERPKLPEGTVDAPLVRLYNFLQMMSLSYQLEILWYQAQRMRSLGWADYLRVEMLNNRKTLSVSYWLRPTPQNIPGRSQMQSRIKLPPHGGTLTISITESRATRKAGGGPARTPVARMLADLQQGAKSGDAHPSDEVEGLMFDVRWEPMKGTLGVIINQEEVLATVGQLEVDSEDLDFEGMLVRVIHAHTRSILLYFQSQLQNGPTRNVFSPEGKVILDSRGAARDYHQLRVHLCADEVAVISIDTRTGRMNLRDTGDLAAAGRWPRFATITDGLNENPNMLLEALSLLRLYTITDSVEQKAKYLGFQVFRHRNFSKEEIQKLGPTARGTIYIQLARFPTHYLVLVITEEDFRYALISVKVLTDSMFANMIMEDIGWLDVRRIRGDRGVGSPGDIMISPLITQVGQRRRRHVGASAQDVLREDSFNLDTQTLRELYAYCCARVAYTRVELQLKRRGIPYIHVNPANSLPPSELSHIQSSLACSVPALCVQSSDILSGAPAAEAAMPNIRVIPLNWWSDKKAQVVTCVKLKYVQQPVGKRAAARATNNIIRPSKRIVYDAMEAVVSFLSENVDTCVDEFLEEWARVSKMVVIAREVARMGKERKWQDVRLLSFDLQTVEFAYAADYTVSISCIDQLSPTGGSFELRFSRSAPTFRPTQPASLAPPPIPVSLRQPRTNPHEEAEPYLRQILRYGSLATSLYRLVGLLRDTLPVVAELDHMITAARGLPGRDRSNSGADEPWFDAFVKGLGWWRVLYGDLRHALDLRLMTNKRIVILDASRSLFQQSLAPQTEEVTELLTFQPIPDFRDLVTEAVRAARPPGAANKERVAMIDIGVVCEGGSVGPVLRALHERVLKKLKE
Length1130
PositionTail
OrganismPisolithus tinctorius Marx 270
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Boletales> Sclerodermatineae> Pisolithaceae> Pisolithus.
Aromaticity0.07
Grand average of hydropathy-0.198
Instability index47.89
Isoelectric point8.56
Molecular weight127100.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02414
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.61|      11|     701|     308|     319|       1
---------------------------------------------------------------------------
  308-  319 (20.34/15.64)	WYQAqRMRSLGW
 1012- 1022 (24.27/13.71)	WFDA.FVKGLGW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.81|      24|     172|     154|     182|       2
---------------------------------------------------------------------------
  154-  182 (38.28/35.23)	KTLnamedTIRYRLRMT.EIIPIE.MSQHRI
  332-  357 (37.53/22.51)	KTL.....SVSYWLRPTpQNIPGRsQMQSRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.15|      13|      21|      90|     102|       4
---------------------------------------------------------------------------
   90-  102 (22.47/15.48)	QNQQFLDVIDRLT
  114-  126 (21.68/14.67)	RNHDLLTSLDVLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.56|      68|     191|     668|     743|       5
---------------------------------------------------------------------------
  668-  743 (107.17/102.02)	IMISPLITQVGQRRRRhvgasaQDVlREDSFNLDTQTLRELYAY.....CCARVAYT..RVELQLKRRGIPYIHVNPAnSL.PP
  862-  937 (106.39/77.50)	VVIAREVARMGKERKW......QDV.RLLSFDLQTVEFAYAADYtvsisCIDQLSPTggSFELRFSRSAPTFRPTQPA.SLaPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.70|      19|      21|     378|     396|       6
---------------------------------------------------------------------------
  378-  396 (31.98/16.29)	KAGGGPARTPVARMLADLQ
  400-  418 (32.72/16.82)	KSGDAHPSDEVEGLMFDVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02414 with Med14 domain of Kingdom Fungi
Unable to open file!