Description | Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MEERDWRKTKLSLERPYKDDQGERIPVLLDITPDGERVFESPENPTKLLGENLRRIFFERGVDFFERQDSLPSGVAQSLEAADQPSEDEENALDPAKTVLTSEELLSLRMECIPRLFIALGEMTEARDLLSLLLSSAPLRHPSAASSLPPLALTATVATKPPPIPSVEVFNAQLALGGKDEALRKAANVFKQAAANLEKSRQSSENYWADALKIRKANWGLVPAPLPLGAPTGKGADKTSKDFFVSFGLEEFPKKSGCPYGNVRC |
Length | 265 |
Position | Head |
Organism | Pisolithus tinctorius Marx 270 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Boletales> Sclerodermatineae> Pisolithaceae> Pisolithus. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.413 |
Instability index | 43.23 |
Isoelectric point | 5.16 |
Molecular weight | 29162.80 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP02408 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.54| 15| 16| 120| 134| 1 --------------------------------------------------------------------------- 120- 134 (23.81/14.85) LGEMTEARDLLSLLL 139- 153 (24.74/15.72) LRHPSAASSLPPLAL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KTKLSLERPYKDDQGERIPVLLDI 2) NLRRIFFE | 8 52 | 31 59 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab