<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02404

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDEPEWKKLKLPLERPYKDDDGKPLPVLFDIAPDGTQTFEPPEDPVSKIGENLMRIFQERGIDFLDRYHDGIEQPKDEATEDKTKDETEDLRIQPMTPEELYKMRVEVVPLLHIAAGEMSFARDMLSVLLATSPQPQIPGIPQTAPTPPKQQFLSASTVTKPPPIQSMQAFNAQIVIGGKDIALRKAADLLKGAAGSVEKSRALSERYWLDALKIRRGNWGLVPAPLPFGTATGRSADKTSKDFLVSFSLEESPAVFRRRAIGRVPIFDTTAGLLEYPLRQNTRLQVSIIREVNGVRHVTKNLPRIFDESQLEDSLRAAQAEVVQQEIFSILIREASSLPTASVRVSERLIAIEAAQATELRFELVDSENASDDVEGTNTPDAACDLIFSALHVLLLRAHAYVKTQRIGRAGVARSGLASTTPPSPPLLQPIADVLQYRVFCDRVHTEVEKMARGLAAAGVPVRLRANRVGESGEQLVAMLTTVDAAQTIGGETLLRVDNRHTLRFTFSSPSSLTAHLPQGTLTISSIPHLTQLLFDEASRCLLDRVCEIGTEMCESVHGIWFVDLLAGRTVGRWEGRVL
Length580
PositionHead
OrganismPhlebiopsis gigantea 11061_1 CR5-6
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Phanerochaetaceae> Phlebiopsis.
Aromaticity0.06
Grand average of hydropathy-0.214
Instability index46.90
Isoelectric point5.59
Molecular weight64048.47
Publications
PubMed=25474575

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02404
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.01|      15|     114|     336|     377|       1
---------------------------------------------------------------------------
  316-  330 (25.39/32.78)	LRAAQA.....EVVQQEIFS
  353-  372 (18.63/19.68)	IEAAQAtelrfELVDSENAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.73|      20|     262|      44|      63|       4
---------------------------------------------------------------------------
   44-   63 (35.54/22.02)	DPVSKIGENLMRIFQERGID
  294-  313 (35.19/21.74)	NGVRHVTKNLPRIFDESQLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.22|      16|      40|     216|     234|       6
---------------------------------------------------------------------------
  216-  234 (27.11/24.16)	RRGNWGLVPAplpFGTATG
  258-  273 (30.10/16.96)	RRRAIGRVPI...FDTTAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02404 with Med17 domain of Kingdom Fungi
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