<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02399

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMGTPIVLAPHGVPAYFLSVYSGPVGGITRQFEDALVGLGCGDWKGAALSQSQNTTPDSSYTYVIAWISVQNKQGEEKGLPVIWPISLAILQDSTLQVRQRLAHIPNLPPQLLASPPAVPVQAPPIRFPLSSLNPPHRSQAASVAISPTTSQSEHSIHLDVKHPGAGLSSSPLTDSMKAFRSLTIRHKNLPNLARDVSTFVSSVAQDREKERERLKRGRDGSSFKISSSPAKQESELTRTPQTPVKRDDIQPIFLVPALTLFLPADPTNIKSADPTALLPAWSPAPNPNLIDQPMLVDDPSSGETIKTGSEAHDTLPETGAPGSNDANVVAGTSTTSFDPYGSFTNTWNQPEKDFMDINAGLDSYSFDMDMAGFTDDDFSFFDAPQSTVRTSAPGLPSVPPTTVPGSHNNFQMSGPGPPSHSAHAVPVVSSVTQLAGMTPRSMPASTPGVVPPELMPSTPAQTPPSQSGPATPAAVVLDHTIHLRRGSASSQGSQFDPVPFGPSHKVMDGKYTSGKFALPTPPPDEIEELWPAARGTVSSSGWKFAYNAKTDPRIGIVRRLVGMKRKRLGEKQRGSYDRLSPAWMHEHEEWTSQPVQGSEDPDTDSSDSDDDLNDDCPEAEDQSAVCPSRPYTPPVPYLPLGPTLVQTGFHHSFLLPLSSTLRPPGTVLDVNMGPLSVPTPVSPAAALGAASERTKALEAVVQLLFKEIVENPFWAEAWQAGLAATRASGSAAPNVWPADVRYTSWMLGCVDGLRNALDLKEAYQADTSDGSPSLKELDDPTLSIGKSDALVQVLPSALRFWEKLGLKPRGGSKDVTAFLFFEKIDDAREEKMASWLQSLSQTYGAKNLGQHALGHAVGCTKDGLIPVQYDAIKKTLTSFVIGLHESTSPTVFYVVVPVHAINLASPLLRQILSAARKVKKARPDAPLLIHLIPEPFITGHLDSPFMRHQGLEILADSVYDRMPVVAKRMSARSLTPDVPRMQALFQEPAFTLARPLARRATFRLEAHPTSLDVVDRLSILHIGYSISPCGKWLLAACIDQRGEAHELRAWLVPSDGAEVFVVNSVWAFAFHVAAKASVEWRIVIAKLGSMEEAEVDAWDSQFHSASREILTSQVFLLCVDPDRPWNFIPPESVEVHKTPRSLQRANKHSAGTVFHDAASSTYLVHNNPTAPLSLDRPISIVPAQPHIPDVEEDASHPPCIIRPLSSLSLVNVPAGTDFTAISMIHLHLLHSIHISSPTVVPLDRIFLDDIAQNYHDLALLTKYRWKLKTSPLLPFHLAALEVMSMALVSTNNESFTD
Length1297
PositionKinase
OrganismPhlebiopsis gigantea 11061_1 CR5-6
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Phanerochaetaceae> Phlebiopsis.
Aromaticity0.07
Grand average of hydropathy-0.211
Instability index53.49
Isoelectric point5.86
Molecular weight140519.58
Publications
PubMed=25474575

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP02399
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     706.32|     189|     233|     551|     782|       2
---------------------------------------------------------------------------
  426-  545 (168.78/63.42)	.PVVS....SVTQLAGMTP..RSMPASTPGV...VPPELM......PSTPAQT...PPSQSGPATPAavVLDHTIHLRRGSASSQGSQFD.PVPF...GPShKVMDGKYTSgkFALPTP....P.......PDEI.....................................................................................EELWPAargTVSSSGWKFA
  551-  748 (318.42/144.90)	DPRIG....IVRRLVGMKR..KRLGEKQRGSYDRLSPAWMHEHEEWTSQPVQGSEDPDTDSSDSDDD..LNDDCPEAEDQSAVCPSRPYTpPVPYLPLGPT.LVQTGFHHS..FLLPLSSTLRP.......PGTVLDVNM.GPLsVPTPVSPAAALGAAseRTKAleavvQLLFKEIVE........NPFWAEAWQAGLA..........ATRASG.SAAPNVWPA...DVRYTSWMLG
  781-  979 (219.12/118.94)	TLSIGksdaLVQVLPSALRfwEKLGLKPRGGSKDVTAFLFFEKIDDAREEKMASWLQSLSQTYGAKN..LGQ...HALGHAVGCTKDGLI.PVQYDAIKKT.LT......S..FVIGLHESTSPtvfyvvvP..VHAINLaSPL.LRQILSAARKVKKA..RPDA.....PLLIHLIPEpfitghldSPFMRHQGLEILAdsvydrmpvvAKRMSArSLTPDV.P..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.10|      22|      23|     251|     273|       4
---------------------------------------------------------------------------
  230-  256 (32.86/17.47)	AkqeseLTR.TPQTPVKRDDIQPIFLVP
  257-  279 (31.99/22.23)	A.....LTLfLPADPTNIKSADPTALLP
 1168- 1182 (20.25/ 6.94)	...........PTAPLSLD..RPISIVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.38|      34|    1073|     125|     163|       6
---------------------------------------------------------------------------
  125-  163 (49.23/41.07)	IRfPLSSL...NPPhrSQAASVAISPTTSQSEHSIHldVKHP
 1201- 1237 (58.15/30.96)	IR.PLSSLslvNVP..AGTDFTAISMIHLHLLHSIH..ISSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.23|      19|      46|    1031|    1050|       7
---------------------------------------------------------------------------
 1031- 1050 (31.24/27.70)	KW.LLAACIDQRGEAhELRAW
 1079- 1098 (29.99/20.13)	EWrIVIAKLGSMEEA.EVDAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.25|      27|      27|     318|     344|       8
---------------------------------------------------------------------------
  318-  344 (48.80/33.20)	T.GAPGSNDANVVAGTSTTSFD.PYGSFT
  346-  374 (41.44/26.96)	TwNQPEKDFMDINAGLDSYSFDmDMAGFT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02399 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADPTALLPAWSPAPNPNLIDQPMLVDDPSSGETIKTGSEAHDTLPETGAPGSNDANVVAGTSTT
2) DDDFSFFDAPQSTVRTSAPGLPSVPPTTVPGSHNNFQMSGPGPPSHSAHAVPVVSSVTQLAGMTPRSMPASTPGVVPPELMPSTPAQTPPSQSGPATPAAVVLDHTIHLRRGSASSQGSQFDPVPFGPSHKVMDGKYTSGKFALPTPPPDEIEELWPAA
3) DVSTFVSSVAQDREKERERLKRGRDGSSFKISSSPAKQESELTRTPQTPVKRDDI
4) HRSQAASVAISPTTSQSEHSIHLDVKHPGAGLSSSPL
5) RLGEKQRGSYDRLSPAWMHEHEEWTSQPVQGSEDPDTDSSDSDDDLNDDCPEAEDQSAVCPSRPYT
272
375
195
136
567
335
533
249
172
632










Molecular Recognition Features






MoRF SequenceStartStop




NANANA