<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02388

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMFEMELPVVCDGQVHLGELLSRVAQATYAELVELAETLPNMSDAARKRTLADWVVKTKKQVVKLYAVMKWARDADTVQTCMNITAFLMNQNQQFLDVIDRLTYAKESLDPARLRNHDLLTSLDVLTSGTYKRLPSAIKKSFIPVPPLTDAEVIKTLNAMEDTIRYRLRMTEIIPIEMSQHRIAGGRVHFIVPKLFETSICLRGAEKDDGWFFVGVKFLFKVGGDTTGNREFPQEPTGILKRHIADEADARMACYLPFPETAEATSEVLSNIEKPERPKLPEGTVDAPLVRLYNFLQMMSLSYQLEILWYQAQRMRSLGWADYLRVEMLNNRKTLSVSYWLRPTPQSIPGRSQMQSRIKLPPHGGTLTISITESRATRKAGGGPARTPVARMLADLQQGAKSGDAHPSDEVEGLMFDVRWEPMKGTLGVIINQEEVLATVGRLEVDSEDLDFEGMLVRVIHAHTRSILLYFQSQLQNGPTRNVFSPEGKVILDSRGAARDYHQLRVHLCADEVAVISIDTRTGRMNLRDTGDLAAAGRWPRFATITDGLNENPNMLLEALSLLRLYTITDSVEQKAKYLGFQVFRHRNFSKEEIQKLGPTARGTIYIQLARFPTHYLVLVITEEDFRYALISVKVLTDSMFANMIMEDIGWLDVRRIRGDRGVGSPGDIMISPLISQAGQRRRRHVGASAQDVLSEDSFNLDTQTLRELYAYCCARVAYTRVELQLKRRGIPYIHVNPANSLPPSELSHIQSSLACSVPALCVQSSDILSGAPAAEAAMPNIRVIPLNWWSDKKAQVVTCVKLKYVQQPVGKRAAAKATNNIIRPSKRIVYDATEAVVSFLSENVDTCVDEFLEEWARVSKMVVIAREVARMGKERKWQDVRLLSFDLQTVEFAYAADYTVSISCTDQLSPTGGSFELRFSRSAPTFRPTQPASLAPPPIPVSLRQPRTNPHEEAEPYLRQILRYGSLATSLYRLVGLLRDTLPVVAELDHMIAAARGLAGRDRSNSGADEPWFDAFVKGLGWWRVLYGDLRHALDLRLMTNKRIVILDASRSLFQQSLAPQTEEVTELLTFQPIPDFRDLVTEAVRAARPPGAANKERVAMIDIGVVCEGGSVGPVLRALHERVLKKLKE
Length1130
PositionTail
OrganismPisolithus tinctorius Marx 270
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Boletales> Sclerodermatineae> Pisolithaceae> Pisolithus.
Aromaticity0.07
Grand average of hydropathy-0.194
Instability index48.73
Isoelectric point8.55
Molecular weight126837.54
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02388
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.88|      79|     177|      99|     185|       1
---------------------------------------------------------------------------
   99-  185 (126.19/105.63)	DRLTYAKESLD.P.ARLRNHDLLTSLDV.LTSGTY..KRLPSAIKKSFIPVPPLTDAeviKTLnamedTIRYRLRMT.EIIPIE.MSQHRIA....GG
  275-  364 (113.69/77.22)	ERPKLPEGTVDaPlVRLYNFLQMMSLSYqLEILWYqaQRMRSLGWADYLRVEMLNNR...KTL.....SVSYWLRPTpQSIPGRsQMQSRIKlpphGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.80|      46|     175|     480|     532|       2
---------------------------------------------------------------------------
  480-  532 (62.20/71.05)	RNVFSPeGKVILdSRGAARDYHQLRVHLCADEVAVISIDTrtgrMNLrDTGDL
  660-  705 (80.60/59.59)	RGVGSP.GDIMI.SPLISQAGQRRRRHVGASAQDVLSEDS....FNL.DTQTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02388 with Med14 domain of Kingdom Fungi
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