<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02388
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MFEMELPVVCDGQVHLGELLSRVAQATYAELVELAETLPNMSDAARKRTLADWVVKTKKQVVKLYAVMKWARDADTVQTCMNITAFLMNQNQQFLDVIDRLTYAKESLDPARLRNHDLLTSLDVLTSGTYKRLPSAIKKSFIPVPPLTDAEVIKTLNAMEDTIRYRLRMTEIIPIEMSQHRIAGGRVHFIVPKLFETSICLRGAEKDDGWFFVGVKFLFKVGGDTTGNREFPQEPTGILKRHIADEADARMACYLPFPETAEATSEVLSNIEKPERPKLPEGTVDAPLVRLYNFLQMMSLSYQLEILWYQAQRMRSLGWADYLRVEMLNNRKTLSVSYWLRPTPQSIPGRSQMQSRIKLPPHGGTLTISITESRATRKAGGGPARTPVARMLADLQQGAKSGDAHPSDEVEGLMFDVRWEPMKGTLGVIINQEEVLATVGRLEVDSEDLDFEGMLVRVIHAHTRSILLYFQSQLQNGPTRNVFSPEGKVILDSRGAARDYHQLRVHLCADEVAVISIDTRTGRMNLRDTGDLAAAGRWPRFATITDGLNENPNMLLEALSLLRLYTITDSVEQKAKYLGFQVFRHRNFSKEEIQKLGPTARGTIYIQLARFPTHYLVLVITEEDFRYALISVKVLTDSMFANMIMEDIGWLDVRRIRGDRGVGSPGDIMISPLISQAGQRRRRHVGASAQDVLSEDSFNLDTQTLRELYAYCCARVAYTRVELQLKRRGIPYIHVNPANSLPPSELSHIQSSLACSVPALCVQSSDILSGAPAAEAAMPNIRVIPLNWWSDKKAQVVTCVKLKYVQQPVGKRAAAKATNNIIRPSKRIVYDATEAVVSFLSENVDTCVDEFLEEWARVSKMVVIAREVARMGKERKWQDVRLLSFDLQTVEFAYAADYTVSISCTDQLSPTGGSFELRFSRSAPTFRPTQPASLAPPPIPVSLRQPRTNPHEEAEPYLRQILRYGSLATSLYRLVGLLRDTLPVVAELDHMIAAARGLAGRDRSNSGADEPWFDAFVKGLGWWRVLYGDLRHALDLRLMTNKRIVILDASRSLFQQSLAPQTEEVTELLTFQPIPDFRDLVTEAVRAARPPGAANKERVAMIDIGVVCEGGSVGPVLRALHERVLKKLKE |
Length | 1130 |
Position | Tail |
Organism | Pisolithus tinctorius Marx 270 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes>
Agaricomycetidae> Boletales> Sclerodermatineae> Pisolithaceae> Pisolithus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.194 |
Instability index | 48.73 |
Isoelectric point | 8.55 |
Molecular weight | 126837.54 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP02388
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 239.88| 79| 177| 99| 185| 1
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99- 185 (126.19/105.63) DRLTYAKESLD.P.ARLRNHDLLTSLDV.LTSGTY..KRLPSAIKKSFIPVPPLTDAeviKTLnamedTIRYRLRMT.EIIPIE.MSQHRIA....GG
275- 364 (113.69/77.22) ERPKLPEGTVDaPlVRLYNFLQMMSLSYqLEILWYqaQRMRSLGWADYLRVEMLNNR...KTL.....SVSYWLRPTpQSIPGRsQMQSRIKlpphGG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 142.80| 46| 175| 480| 532| 2
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480- 532 (62.20/71.05) RNVFSPeGKVILdSRGAARDYHQLRVHLCADEVAVISIDTrtgrMNLrDTGDL
660- 705 (80.60/59.59) RGVGSP.GDIMI.SPLISQAGQRRRRHVGASAQDVLSEDS....FNL.DTQTL
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