<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02375

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSAAQSWSKFLSHSLATRLEPESFESYVQLLSSKSPLSPSHISDLFLRPSATNGGSLDPRIPRYMQIMLALELVNIPAILRALRKYSTFGAVLETQDADRQSKGTSRGGEEDERRKVGERRNRWSNSYATEETLFYQAAKYITSGRAPKHIQETIDLILVTIKWMELVTSAGNKASEMLNLGHTQAQEMSATTTALGTLVVTVVDNARVVEALSKKSCPKGTVTLLSKTLGDFVPLLMHPPTAGRLELFRSQTLVAIEPPEKKSSASNAIDDMLDEGLNLGMDSLVIADVPSINSRAGLYIYLSALGDVQSTAIDLILASFDILANAKLHNEAVQTTTLLRSFLINKVPLLLTALSASFYPPLTSEFCITAAFSRVDTNAFPTLSTLFDESSSNDMFSDSVRQDFCFACCLHGLVEESSIEALLGDIPMQSLPAGGRYVKDDLVQQFLSDPEKIESMIDELDHMDGNVGAVSQALTEVIGRLCSNRETVTLKMICSLLARKSSSLDVMLLFDKPITILRPICDLLDNWHYDEDQVEYQPVYEEFGSVLLLLLSFVHRYNLSTTDLGIYSHSSFVAKLLDQGHLSRAMDTLTGQEQNHLDGWIRGLFDNESGGLGDELMSSCPPQDFHLLVPTLFHHIVLACSTNNLPEESLRGGLELFVEPFLLPSLIPAITWLSSHLWESRGDANAVLQILSALITNPASISNNMEASQMLNTIINIVAKNLEHSLRWLQRAEPQRQDVEPLSKALRSNLGWERRGASEHMELESWTSTTGGGITAAIKITINGLVHWGINPGINISPANYTHRQILVGLKLLGAKRLLSTILDEVRAQDEAGNGPAVLDVATALVCAPDVLSWDTTSGIDIMEDASSRTPLQRRMTLREALKIEAENAPKLHKTDPVQAETAIRLHRRVETQMAVQQPPLIPSDAMGGLDVALHGALDAALDDAIAGGMGNGQSIEDVINAETDLMTGLITGADGMEGDIFSQMGDGITF
Length992
PositionTail
OrganismOidiodendron maius Zn
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Myxotrichaceae> Oidiodendron.
Aromaticity0.06
Grand average of hydropathy-0.044
Instability index50.40
Isoelectric point4.92
Molecular weight108416.24
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02375
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     287.45|      99|     157|     600|     756|       1
---------------------------------------------------------------------------
  583-  703 (140.44/144.49)	LSRAMDTLTGQEQ......nhldGWirglfDNESGGlGdelmsscPPQDFHLLVPTLFHHIV...LACSTNNLPEESLRGGLELFVEPFLLPSLIPAItwlssHLWESRGDANAVLQILSALITNPASIS
  743-  854 (147.01/65.56)	LSKALRSNLGWERrgasehmeleSW.....TSTTGG.G.......ITAAIKITINGLVHWGInpgINISPANYTHRQILVGLKLLGAKRLLSTILDEV.....RAQDEAGNGPAVLDVATALVCAPDVLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      58.68|      14|      22|     415|     428|       2
---------------------------------------------------------------------------
  389-  401 (16.17/ 8.81)	.DESSSNDMFSDSV
  415-  428 (21.90/14.98)	VEESSIEALLGDIP
  439-  451 (20.62/13.61)	VKDDLVQQFLSD.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.11|      22|     153|     332|     368|       4
---------------------------------------------------------------------------
  222-  243 (40.00/16.33)	TVTLLSKTLGDFVPLLMHPPTA
  336-  357 (36.10/36.17)	TTTLLRSFLINKVPLLLTALSA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02375 with Med5 domain of Kingdom Fungi
Unable to open file!